Glaucoma is probably not useful as a red flag for amyloidosis
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Glaucoma is probably not useful as a red flag for amyloidosis. / Westin, Oscar; Butt, Jawad H.; Heegaard, Steffen; Fosbøl, Emil L.; Gustafsson, Finn.
I: Scandinavian Cardiovascular Journal, Bind 57, Nr. 1, 2181389, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Glaucoma is probably not useful as a red flag for amyloidosis
AU - Westin, Oscar
AU - Butt, Jawad H.
AU - Heegaard, Steffen
AU - Fosbøl, Emil L.
AU - Gustafsson, Finn
N1 - Publisher Copyright: © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023
Y1 - 2023
N2 - Purpose. Transthyretin is produced in the retina and approximately one quarter of patients with variant transthyretin amyloidosis (ATTRv) develop ocular involvement. Glaucoma is the most important ocular manifestation, leading to rapid loss of vision. The usefulness of glaucoma as a red flag for cardiac amyloidosis is unknown. Materials and Methods. On a national scale, we investigated the association between glaucoma and development of amyloidosis, compared to an age- and sex-matched population from the general population. Results. The study population included 365,496 subjects (1:1 ratio). Adjusted Cox-models showed no significant association between glaucoma and future diagnosis of amyloidosis (hazard ratio: 1.16 [0.80–1.70], p =.44). Conclusion. We conclude that while ocular involvement is a possible early manifestation of ATTRv, nationwide data suggest that glaucoma is probably not useful as a red flag for cardiac amyloidosis.
AB - Purpose. Transthyretin is produced in the retina and approximately one quarter of patients with variant transthyretin amyloidosis (ATTRv) develop ocular involvement. Glaucoma is the most important ocular manifestation, leading to rapid loss of vision. The usefulness of glaucoma as a red flag for cardiac amyloidosis is unknown. Materials and Methods. On a national scale, we investigated the association between glaucoma and development of amyloidosis, compared to an age- and sex-matched population from the general population. Results. The study population included 365,496 subjects (1:1 ratio). Adjusted Cox-models showed no significant association between glaucoma and future diagnosis of amyloidosis (hazard ratio: 1.16 [0.80–1.70], p =.44). Conclusion. We conclude that while ocular involvement is a possible early manifestation of ATTRv, nationwide data suggest that glaucoma is probably not useful as a red flag for cardiac amyloidosis.
KW - Cardiac amyloidosis
KW - epidemiology
KW - glaucoma
KW - red flag
U2 - 10.1080/14017431.2023.2181389
DO - 10.1080/14017431.2023.2181389
M3 - Journal article
C2 - 36825614
AN - SCOPUS:85149941667
VL - 57
JO - Scandinavian Cardiovascular Journal
JF - Scandinavian Cardiovascular Journal
SN - 1401-7458
IS - 1
M1 - 2181389
ER -
ID: 366543600