Glaucoma is probably not useful as a red flag for amyloidosis

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Standard

Glaucoma is probably not useful as a red flag for amyloidosis. / Westin, Oscar; Butt, Jawad H.; Heegaard, Steffen; Fosbøl, Emil L.; Gustafsson, Finn.

I: Scandinavian Cardiovascular Journal, Bind 57, Nr. 1, 2181389, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Westin, O, Butt, JH, Heegaard, S, Fosbøl, EL & Gustafsson, F 2023, 'Glaucoma is probably not useful as a red flag for amyloidosis', Scandinavian Cardiovascular Journal, bind 57, nr. 1, 2181389. https://doi.org/10.1080/14017431.2023.2181389

APA

Westin, O., Butt, J. H., Heegaard, S., Fosbøl, E. L., & Gustafsson, F. (2023). Glaucoma is probably not useful as a red flag for amyloidosis. Scandinavian Cardiovascular Journal, 57(1), [2181389]. https://doi.org/10.1080/14017431.2023.2181389

Vancouver

Westin O, Butt JH, Heegaard S, Fosbøl EL, Gustafsson F. Glaucoma is probably not useful as a red flag for amyloidosis. Scandinavian Cardiovascular Journal. 2023;57(1). 2181389. https://doi.org/10.1080/14017431.2023.2181389

Author

Westin, Oscar ; Butt, Jawad H. ; Heegaard, Steffen ; Fosbøl, Emil L. ; Gustafsson, Finn. / Glaucoma is probably not useful as a red flag for amyloidosis. I: Scandinavian Cardiovascular Journal. 2023 ; Bind 57, Nr. 1.

Bibtex

@article{a396d53c2e47481aac13b83679fa461c,

title = "Glaucoma is probably not useful as a red flag for amyloidosis",

abstract = "Purpose. Transthyretin is produced in the retina and approximately one quarter of patients with variant transthyretin amyloidosis (ATTRv) develop ocular involvement. Glaucoma is the most important ocular manifestation, leading to rapid loss of vision. The usefulness of glaucoma as a red flag for cardiac amyloidosis is unknown. Materials and Methods. On a national scale, we investigated the association between glaucoma and development of amyloidosis, compared to an age- and sex-matched population from the general population. Results. The study population included 365,496 subjects (1:1 ratio). Adjusted Cox-models showed no significant association between glaucoma and future diagnosis of amyloidosis (hazard ratio: 1.16 [0.80–1.70], p =.44). Conclusion. We conclude that while ocular involvement is a possible early manifestation of ATTRv, nationwide data suggest that glaucoma is probably not useful as a red flag for cardiac amyloidosis.",

keywords = "Cardiac amyloidosis, epidemiology, glaucoma, red flag",

author = "Oscar Westin and Butt, {Jawad H.} and Steffen Heegaard and Fosb{\o}l, {Emil L.} and Finn Gustafsson",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",

year = "2023",

doi = "10.1080/14017431.2023.2181389",

language = "English",

volume = "57",

journal = "Scandinavian Cardiovascular Journal",

issn = "1401-7458",

publisher = "Taylor & Francis",

number = "1",

}

RIS

TY - JOUR

T1 - Glaucoma is probably not useful as a red flag for amyloidosis

AU - Westin, Oscar

AU - Butt, Jawad H.

AU - Heegaard, Steffen

AU - Fosbøl, Emil L.

AU - Gustafsson, Finn

PY - 2023

Y1 - 2023

N2 - Purpose. Transthyretin is produced in the retina and approximately one quarter of patients with variant transthyretin amyloidosis (ATTRv) develop ocular involvement. Glaucoma is the most important ocular manifestation, leading to rapid loss of vision. The usefulness of glaucoma as a red flag for cardiac amyloidosis is unknown. Materials and Methods. On a national scale, we investigated the association between glaucoma and development of amyloidosis, compared to an age- and sex-matched population from the general population. Results. The study population included 365,496 subjects (1:1 ratio). Adjusted Cox-models showed no significant association between glaucoma and future diagnosis of amyloidosis (hazard ratio: 1.16 [0.80–1.70], p =.44). Conclusion. We conclude that while ocular involvement is a possible early manifestation of ATTRv, nationwide data suggest that glaucoma is probably not useful as a red flag for cardiac amyloidosis.

AB - Purpose. Transthyretin is produced in the retina and approximately one quarter of patients with variant transthyretin amyloidosis (ATTRv) develop ocular involvement. Glaucoma is the most important ocular manifestation, leading to rapid loss of vision. The usefulness of glaucoma as a red flag for cardiac amyloidosis is unknown. Materials and Methods. On a national scale, we investigated the association between glaucoma and development of amyloidosis, compared to an age- and sex-matched population from the general population. Results. The study population included 365,496 subjects (1:1 ratio). Adjusted Cox-models showed no significant association between glaucoma and future diagnosis of amyloidosis (hazard ratio: 1.16 [0.80–1.70], p =.44). Conclusion. We conclude that while ocular involvement is a possible early manifestation of ATTRv, nationwide data suggest that glaucoma is probably not useful as a red flag for cardiac amyloidosis.

KW - Cardiac amyloidosis

KW - epidemiology

KW - glaucoma

KW - red flag

U2 - 10.1080/14017431.2023.2181389

DO - 10.1080/14017431.2023.2181389

M3 - Journal article

C2 - 36825614

AN - SCOPUS:85149941667

VL - 57

JO - Scandinavian Cardiovascular Journal

JF - Scandinavian Cardiovascular Journal

SN - 1401-7458

IS - 1

M1 - 2181389

ER -

ID: 366543600