GH receptor blocker administration and muscle-tendon collagen synthesis in humans
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GH receptor blocker administration and muscle-tendon collagen synthesis in humans. / Nielsen, Rie H; Doessing, Simon; Goto, K.; Reitelseder, S; Holm, Lars; Agergaard, J; Schjerling, Peter; Flyvbjerg, A; Kjær, Michael.
I: Growth Hormone & IGF Research, Bind 21, Nr. 3, 2011, s. 140-145.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - GH receptor blocker administration and muscle-tendon collagen synthesis in humans
AU - Nielsen, Rie H
AU - Doessing, Simon
AU - Goto, K.
AU - Reitelseder, S
AU - Holm, Lars
AU - Agergaard, J
AU - Schjerling, Peter
AU - Flyvbjerg, A
AU - Kjær, Michael
N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.
PY - 2011
Y1 - 2011
N2 - Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62 ± 1 years (mean ± SEM), BMI 27 ± 1] participated. Two injections of either human recombinant IGF-I (0.1 mL Increlex©) or saline (control) into each patellar tendon were performed 24-h apart, respectively. Tendon collagen fractional synthesis rate (FSR) was measured by stable isotope technique in the hours after the second injection. Simultaneously, interstitial peritendinous (IGF-I) and [procollagen type I N-terminal propeptide (PINP)], as a marker for type I collagen synthesis, were determined by microdialysis technique. Tendon collagen FSR and PINP were significantly higher in the IGF-I leg compared with the control leg (P < 0.05). In conclusion, local IGF-I administration can directly enhance tendon collagen synthesis both within and around the human tendon tissue.
AB - Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62 ± 1 years (mean ± SEM), BMI 27 ± 1] participated. Two injections of either human recombinant IGF-I (0.1 mL Increlex©) or saline (control) into each patellar tendon were performed 24-h apart, respectively. Tendon collagen fractional synthesis rate (FSR) was measured by stable isotope technique in the hours after the second injection. Simultaneously, interstitial peritendinous (IGF-I) and [procollagen type I N-terminal propeptide (PINP)], as a marker for type I collagen synthesis, were determined by microdialysis technique. Tendon collagen FSR and PINP were significantly higher in the IGF-I leg compared with the control leg (P < 0.05). In conclusion, local IGF-I administration can directly enhance tendon collagen synthesis both within and around the human tendon tissue.
U2 - 10.1016/j.ghir.2011.03.006
DO - 10.1016/j.ghir.2011.03.006
M3 - Journal article
C2 - 21498100
VL - 21
SP - 140
EP - 145
JO - Growth Hormone & I G F Research
JF - Growth Hormone & I G F Research
SN - 1096-6374
IS - 3
ER -
ID: 40170935