Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors

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Standard

Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors. / Olofsson, Isa Amalie; Kristjansson, Ragnar P.; Callesen, Ida; Davidsson, Olafur; Winsvold, Bendik; Hjalgrim, Henrik; Ostrowski, Sisse R.; Erikstrup, Christian; Bruun, Mie Topholm; Pedersen, Ole Birger; Burgdorf, Kristoffer S.; Banasik, Karina; Sørensen, Erik; Mikkelsen, Christina; Didriksen, Maria; Dinh, Khoa Manh; Mikkelsen, Susan; Brunak, Søren; Ullum, Henrik; Chalmer, Mona Ameri; Olesen, Jes; Kogelman, Lisette J.A.; Hansen, Thomas Folkmann; International Headache Genetic Consortium; DBDS Genomic Consortium.

I: Communications Biology , Bind 7, Nr. 1, 646, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Olofsson, IA, Kristjansson, RP, Callesen, I, Davidsson, O, Winsvold, B, Hjalgrim, H, Ostrowski, SR, Erikstrup, C, Bruun, MT, Pedersen, OB, Burgdorf, KS, Banasik, K, Sørensen, E, Mikkelsen, C, Didriksen, M, Dinh, KM, Mikkelsen, S, Brunak, S, Ullum, H, Chalmer, MA, Olesen, J, Kogelman, LJA, Hansen, TF, International Headache Genetic Consortium & DBDS Genomic Consortium 2024, 'Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors', Communications Biology , bind 7, nr. 1, 646. https://doi.org/10.1038/s42003-024-06299-y

APA

Olofsson, I. A., Kristjansson, R. P., Callesen, I., Davidsson, O., Winsvold, B., Hjalgrim, H., Ostrowski, S. R., Erikstrup, C., Bruun, M. T., Pedersen, O. B., Burgdorf, K. S., Banasik, K., Sørensen, E., Mikkelsen, C., Didriksen, M., Dinh, K. M., Mikkelsen, S., Brunak, S., Ullum, H., ... DBDS Genomic Consortium (2024). Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors. Communications Biology , 7(1), [646]. https://doi.org/10.1038/s42003-024-06299-y

Vancouver

Olofsson IA, Kristjansson RP, Callesen I, Davidsson O, Winsvold B, Hjalgrim H o.a. Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors. Communications Biology . 2024;7(1). 646. https://doi.org/10.1038/s42003-024-06299-y

Author

Olofsson, Isa Amalie ; Kristjansson, Ragnar P. ; Callesen, Ida ; Davidsson, Olafur ; Winsvold, Bendik ; Hjalgrim, Henrik ; Ostrowski, Sisse R. ; Erikstrup, Christian ; Bruun, Mie Topholm ; Pedersen, Ole Birger ; Burgdorf, Kristoffer S. ; Banasik, Karina ; Sørensen, Erik ; Mikkelsen, Christina ; Didriksen, Maria ; Dinh, Khoa Manh ; Mikkelsen, Susan ; Brunak, Søren ; Ullum, Henrik ; Chalmer, Mona Ameri ; Olesen, Jes ; Kogelman, Lisette J.A. ; Hansen, Thomas Folkmann ; International Headache Genetic Consortium ; DBDS Genomic Consortium. / Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors. I: Communications Biology . 2024 ; Bind 7, Nr. 1.

Bibtex

@article{4cb9f4d53f32434cb67ab3c7e2a38853,

title = "Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors",

abstract = "Headache disorders are the most common disorders of the nervous system. The lifetime prevalence of headache disorders show that some individuals never experience headache. The etiology of complete freedom from headache is not known. To assess genetic variants associated with complete freedom from headache, we performed a genome-wide association study of individuals who have never experienced a headache. We included 63,992 individuals (2,998 individuals with complete freedom from headache and 60,994 controls) from the Danish Blood Donor Study Genomic Cohort. Participants were included in two rounds, from 2015 to 2018 and in 2020. We discovered a genome-wide significant association, with the lead variant rs7904615[G] in ADARB2 (EAF = 27%, OR = 1.20 [1.13-1.27], p = 3.92 × 10-9). The genomic locus was replicated in a non-overlapping cohort of 13,032 individuals (539 individuals with complete freedom from headache and 12,493 controls) from the Danish Blood Donor Study Genomic Cohort (p < 0.05, two-sided). Participants for the replication were included from 2015 to 2020. In conclusion, we show that complete freedom from headache has a genetic component, and we suggest that ADARB2 is involved in complete freedom from headache. The genomic locus was specific for complete freedom from headache and was not associated with any primary headache disorders.",

author = "Olofsson, {Isa Amalie} and Kristjansson, {Ragnar P.} and Ida Callesen and Olafur Davidsson and Bendik Winsvold and Henrik Hjalgrim and Ostrowski, {Sisse R.} and Christian Erikstrup and Bruun, {Mie Topholm} and Pedersen, {Ole Birger} and Burgdorf, {Kristoffer S.} and Karina Banasik and Erik S{\o}rensen and Christina Mikkelsen and Maria Didriksen and Dinh, {Khoa Manh} and Susan Mikkelsen and S{\o}ren Brunak and Henrik Ullum and Chalmer, {Mona Ameri} and Jes Olesen and Kogelman, {Lisette J.A.} and Hansen, {Thomas Folkmann} and {International Headache Genetic Consortium} and {DBDS Genomic Consortium}",

note = "Publisher Copyright: {\textcopyright} 2024. The Author(s).",

year = "2024",

doi = "10.1038/s42003-024-06299-y",

language = "English",

volume = "7",

journal = "Communications Biology",

issn = "2399-3642",

publisher = "nature publishing group",

number = "1",

}

RIS

TY - JOUR

T1 - Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors

AU - Olofsson, Isa Amalie

AU - Kristjansson, Ragnar P.

AU - Callesen, Ida

AU - Davidsson, Olafur

AU - Winsvold, Bendik

AU - Hjalgrim, Henrik

AU - Ostrowski, Sisse R.

AU - Erikstrup, Christian

AU - Bruun, Mie Topholm

AU - Pedersen, Ole Birger

AU - Burgdorf, Kristoffer S.

AU - Banasik, Karina

AU - Sørensen, Erik

AU - Mikkelsen, Christina

AU - Didriksen, Maria

AU - Dinh, Khoa Manh

AU - Mikkelsen, Susan

AU - Brunak, Søren

AU - Ullum, Henrik

AU - Chalmer, Mona Ameri

AU - Olesen, Jes

AU - Kogelman, Lisette J.A.

AU - Hansen, Thomas Folkmann

AU - International Headache Genetic Consortium

AU - DBDS Genomic Consortium

PY - 2024

Y1 - 2024

N2 - Headache disorders are the most common disorders of the nervous system. The lifetime prevalence of headache disorders show that some individuals never experience headache. The etiology of complete freedom from headache is not known. To assess genetic variants associated with complete freedom from headache, we performed a genome-wide association study of individuals who have never experienced a headache. We included 63,992 individuals (2,998 individuals with complete freedom from headache and 60,994 controls) from the Danish Blood Donor Study Genomic Cohort. Participants were included in two rounds, from 2015 to 2018 and in 2020. We discovered a genome-wide significant association, with the lead variant rs7904615[G] in ADARB2 (EAF = 27%, OR = 1.20 [1.13-1.27], p = 3.92 × 10-9). The genomic locus was replicated in a non-overlapping cohort of 13,032 individuals (539 individuals with complete freedom from headache and 12,493 controls) from the Danish Blood Donor Study Genomic Cohort (p < 0.05, two-sided). Participants for the replication were included from 2015 to 2020. In conclusion, we show that complete freedom from headache has a genetic component, and we suggest that ADARB2 is involved in complete freedom from headache. The genomic locus was specific for complete freedom from headache and was not associated with any primary headache disorders.

AB - Headache disorders are the most common disorders of the nervous system. The lifetime prevalence of headache disorders show that some individuals never experience headache. The etiology of complete freedom from headache is not known. To assess genetic variants associated with complete freedom from headache, we performed a genome-wide association study of individuals who have never experienced a headache. We included 63,992 individuals (2,998 individuals with complete freedom from headache and 60,994 controls) from the Danish Blood Donor Study Genomic Cohort. Participants were included in two rounds, from 2015 to 2018 and in 2020. We discovered a genome-wide significant association, with the lead variant rs7904615[G] in ADARB2 (EAF = 27%, OR = 1.20 [1.13-1.27], p = 3.92 × 10-9). The genomic locus was replicated in a non-overlapping cohort of 13,032 individuals (539 individuals with complete freedom from headache and 12,493 controls) from the Danish Blood Donor Study Genomic Cohort (p < 0.05, two-sided). Participants for the replication were included from 2015 to 2020. In conclusion, we show that complete freedom from headache has a genetic component, and we suggest that ADARB2 is involved in complete freedom from headache. The genomic locus was specific for complete freedom from headache and was not associated with any primary headache disorders.

U2 - 10.1038/s42003-024-06299-y

DO - 10.1038/s42003-024-06299-y

M3 - Journal article

C2 - 38802570

AN - SCOPUS:85194521800

VL - 7

JO - Communications Biology

JF - Communications Biology

SN - 2399-3642

IS - 1

M1 - 646

ER -

ID: 394337620