Genome-wide association study of serum selenium concentrations
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Genome-wide association study of serum selenium concentrations. / Gong, Jian; Hsu, Li; Harrison, Tabitha; B. King, Irena; Stürup, Stefan; Song, Xiaoling; Duggan, David; Liu, Yan; Hutter, Carolyn; J. Chanock, Stephen; B. Eaton, Charles; R. Marshall, James; Peters, Ulrike.
I: Nutrients, Bind 5, Nr. 5, 2013, s. 1706-1718.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Genome-wide association study of serum selenium concentrations
AU - Gong, Jian
AU - Hsu, Li
AU - Harrison, Tabitha
AU - B. King, Irena
AU - Stürup, Stefan
AU - Song, Xiaoling
AU - Duggan, David
AU - Liu, Yan
AU - Hutter, Carolyn
AU - J. Chanock, Stephen
AU - B. Eaton, Charles
AU - R. Marshall, James
AU - Peters, Ulrike
PY - 2013
Y1 - 2013
N2 - Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, nostudy has comprehensively investigated this hypothesis. Therefore, we conducted atwo-stage genome-wide association study to identify genetic variants associated withserum selenium concentrations in 1203 European descents from two cohorts: theProstate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women’sHealth Initiative (WHI). We tested association between 2,474,333 single nucleotidepolymorphisms (SNPs) and serum selenium concentrations using linear regression models.In the first stage (PLCO) 41 SNPs clustered in 15 regions had p < 1 × 10−5. None of these41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003) in the second stage(WHI). Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11) and had p between 2.62 × 10−7and 4.04 × 10−7 in the combined analysis (PLCO + WHI). Additional studies are needed toreplicate these findings. Identification of genetic variation that impacts seleniumconcentrations may contribute to a better understanding of which genes regulate circulatingselenium concentrations.
AB - Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, nostudy has comprehensively investigated this hypothesis. Therefore, we conducted atwo-stage genome-wide association study to identify genetic variants associated withserum selenium concentrations in 1203 European descents from two cohorts: theProstate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women’sHealth Initiative (WHI). We tested association between 2,474,333 single nucleotidepolymorphisms (SNPs) and serum selenium concentrations using linear regression models.In the first stage (PLCO) 41 SNPs clustered in 15 regions had p < 1 × 10−5. None of these41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003) in the second stage(WHI). Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11) and had p between 2.62 × 10−7and 4.04 × 10−7 in the combined analysis (PLCO + WHI). Additional studies are needed toreplicate these findings. Identification of genetic variation that impacts seleniumconcentrations may contribute to a better understanding of which genes regulate circulatingselenium concentrations.
U2 - 10.3390/nu5051706
DO - 10.3390/nu5051706
M3 - Journal article
C2 - 23698163
VL - 5
SP - 1706
EP - 1718
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 5
ER -
ID: 45944824