Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. / Reveille, John D.; Sims, Anne Marie; Danoy, Patrick; Evans, David M.; Leo, Paul; Pointon, Jennifer J.; Jin, Rui; Zhou, Xiaodong; Bradbury, Linda A.; Appleton, Louise H.; Davis, John C.; Diekman, Laura; Doan, Tracey; Dowling, Alison; Duan, Ran; Duncan, Emma L.; Farrar, Claire; Hadler, Johanna; Harvey, David; Karaderi, Tugce; Mogg, Rebecca; Pomeroy, Emma; Pryce, Karena; Taylor, Jacqueline; Savage, Laurie; Deloukas, Panos; Kumanduri, Vasudev; Peltonen, Leena; Ring, Sue M.; Whittaker, Pamela; Glazov, Evgeny; Thomas, Gethin P.; Maksymowych, Walter P.; Inman, Robert D.; Ward, Michael M.; Stone, Millicent A.; Weisman, Michael H.; Wordsworth, B. Paul; Brown, Matthew A.
I: Nature Genetics, Bind 42, Nr. 2, 01.02.2010, s. 123-127.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
AU - Reveille, John D.
AU - Sims, Anne Marie
AU - Danoy, Patrick
AU - Evans, David M.
AU - Leo, Paul
AU - Pointon, Jennifer J.
AU - Jin, Rui
AU - Zhou, Xiaodong
AU - Bradbury, Linda A.
AU - Appleton, Louise H.
AU - Davis, John C.
AU - Diekman, Laura
AU - Doan, Tracey
AU - Dowling, Alison
AU - Duan, Ran
AU - Duncan, Emma L.
AU - Farrar, Claire
AU - Hadler, Johanna
AU - Harvey, David
AU - Karaderi, Tugce
AU - Mogg, Rebecca
AU - Pomeroy, Emma
AU - Pryce, Karena
AU - Taylor, Jacqueline
AU - Savage, Laurie
AU - Deloukas, Panos
AU - Kumanduri, Vasudev
AU - Peltonen, Leena
AU - Ring, Sue M.
AU - Whittaker, Pamela
AU - Glazov, Evgeny
AU - Thomas, Gethin P.
AU - Maksymowych, Walter P.
AU - Inman, Robert D.
AU - Ward, Michael M.
AU - Stone, Millicent A.
AU - Weisman, Michael H.
AU - Wordsworth, B. Paul
AU - Brown, Matthew A.
PY - 2010/2/1
Y1 - 2010/2/1
N2 - To identify susceptibility loci for ankylosing spondylitis, we undertook a genome-wide association study in 2,053 unrelated ankylosing spondylitis cases among people of European descent and 5,140 ethnically matched controls, with replication in an independent cohort of 898 ankylosing spondylitis cases and 1,518 controls. Cases were genotyped with Illumina HumHap370 genotyping chips. In addition to strong association with the major histocompatibility complex (MHC; P 10 800), we found association with SNPs in two gene deserts at 2p15 (rs10865331; combined P = 1.9 × 10 19) and 21q22 (rs2242944; P = 8.3 × 10 20), as well as in the genes ANTXR2 (rs4333130; P = 9.3 × 10 8) and IL1R2 (rs2310173; P = 4.8 × 10 7). We also replicated previously reported associations at IL23R (rs11209026; P = 9.1 × 10 14) and ERAP1 (rs27434; P = 5.3 × 10 12). This study reports four genetic loci associated with ankylosing spondylitis risk and identifies a major role for the interleukin (IL)-23 and IL-1 cytokine pathways in disease susceptibility.
AB - To identify susceptibility loci for ankylosing spondylitis, we undertook a genome-wide association study in 2,053 unrelated ankylosing spondylitis cases among people of European descent and 5,140 ethnically matched controls, with replication in an independent cohort of 898 ankylosing spondylitis cases and 1,518 controls. Cases were genotyped with Illumina HumHap370 genotyping chips. In addition to strong association with the major histocompatibility complex (MHC; P 10 800), we found association with SNPs in two gene deserts at 2p15 (rs10865331; combined P = 1.9 × 10 19) and 21q22 (rs2242944; P = 8.3 × 10 20), as well as in the genes ANTXR2 (rs4333130; P = 9.3 × 10 8) and IL1R2 (rs2310173; P = 4.8 × 10 7). We also replicated previously reported associations at IL23R (rs11209026; P = 9.1 × 10 14) and ERAP1 (rs27434; P = 5.3 × 10 12). This study reports four genetic loci associated with ankylosing spondylitis risk and identifies a major role for the interleukin (IL)-23 and IL-1 cytokine pathways in disease susceptibility.
UR - http://www.scopus.com/inward/record.url?scp=75749085686&partnerID=8YFLogxK
U2 - 10.1038/ng.513
DO - 10.1038/ng.513
M3 - Journal article
C2 - 20062062
AN - SCOPUS:75749085686
VL - 42
SP - 123
EP - 127
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 2
ER -
ID: 226397315