Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. / Barrett, Jeffrey C; Clayton, David G; Concannon, Patrick; Akolkar, Beena; Cooper, Jason D; Erlich, Henry A; Julier, Cécile; Morahan, Grant; Nerup, Jørn; Nierras, Concepcion; Plagnol, Vincent; Pociot, Flemming; Schuilenburg, Helen; Smyth, Deborah J; Stevens, Helen; Todd, John A; Walker, Neil M; Rich, Stephen S; The Type 1 Diabetes Genetics Consortium.
I: Nature Genetics, 2009.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
AU - Barrett, Jeffrey C
AU - Clayton, David G
AU - Concannon, Patrick
AU - Akolkar, Beena
AU - Cooper, Jason D
AU - Erlich, Henry A
AU - Julier, Cécile
AU - Morahan, Grant
AU - Nerup, Jørn
AU - Nierras, Concepcion
AU - Plagnol, Vincent
AU - Pociot, Flemming
AU - Schuilenburg, Helen
AU - Smyth, Deborah J
AU - Stevens, Helen
AU - Todd, John A
AU - Walker, Neil M
AU - Rich, Stephen S
AU - The Type 1 Diabetes Genetics Consortium
PY - 2009
Y1 - 2009
N2 - Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 x 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.
AB - Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 x 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.
U2 - 10.1038/ng.381
DO - 10.1038/ng.381
M3 - Journal article
C2 - 19430480
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
ER -
ID: 21183814