Standard
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. / Nievergelt, Caroline M.; Maihofer, Adam X.; Atkinson, Elizabeth G.; Chen, Chia Yen; Choi, Karmel W.; Coleman, Jonathan R.I.; Daskalakis, Nikolaos P.; Duncan, Laramie E.; Polimanti, Renato; Aaronson, Cindy; Amstadter, Ananda B.; Andersen, Soren B.; Andreassen, Ole A.; Arbisi, Paul A.; Ashley-Koch, Allison E.; Austin, S. Bryn; Avdibegoviç, Esmina; Babić, Dragan; Bacanu, Silviu Alin; Baker, Dewleen G.; Batzler, Anthony; Beckham, Jean C.; Belangero, Sintia; Benjet, Corina; Bergner, Carisa; Bierer, Linda M.; Biernacka, Joanna M.; Bierut, Laura J.; Bisson, Jonathan I.; Boks, Marco P.; Bolger, Elizabeth A.; Brandolino, Amber; Breen, Gerome; Bressan, Rodrigo Affonseca; Bryant, Richard A.; Bustamante, Angela C.; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Børglum, Anders D.; Børte, Sigrid; Cahn, Leah; Calabrese, Joseph R.; Caldas-de-Almeida, Jose Miguel; Chatzinakos, Chris; Cheema, Sheraz; Clouston, Sean A.P.; Colodro-Conde, Lucía; Coombes, Brandon J.; Cruz-Fuentes, Carlos S.; Dale, Anders M.; Dalvie, Shareefa; Davis, Lea K.; Deckert, Jürgen; Delahanty, Douglas L.; Dennis, Michelle F.; Desarnaud, Frank; DiPietro, Christopher P.; Disner, Seth G.; Docherty, Anna R.; Domschke, Katharina; Dyb, Grete; Kulenović, Alma Džubur; Edenberg, Howard J.; Evans, Alexandra; Fabbri, Chiara; Fani, Negar; Farrer, Lindsay A.; Feder, Adriana; Feeny, Norah C.; Flory, Janine D.; Forbes, David; Franz, Carol E.; Galea, Sandro; Garrett, Melanie E.; Gelaye, Bizu; Gelernter, Joel; Geuze, Elbert; Gillespie, Charles F.; Goleva, Slavina B.; Gordon, Scott D.; Goçi, Aferdita; Grasser, Lana Ruvolo; Guindalini, Camila; Haas, Magali; Hagenaars, Saskia; Hauser, Michael A.; Heath, Andrew C.; Hemmings, Sian M.J.; Hesselbrock, Victor; Hickie, Ian B.; Hogan, Kelleigh; Hougaard, David Michael; Huang, Hailiang; Huckins, Laura M.; Hveem, Kristian; Jakovljević, Miro; Javanbakht, Arash; Jenkins, Gregory D.; Johnson, Jessica; Jones, Ian; Jovanovic, Tanja; Karstoft, Karen Inge; Kaufman, Milissa L.; Kennedy, James L.; Kessler, Ronald C.; Khan, Alaptagin; Kimbrel, Nathan A.; King, Anthony P.; Koen, Nastassja; Kotov, Roman; Kranzler, Henry R.; Krebs, Kristi; Kremen, William S.; Kuan, Pei Fen; Lawford, Bruce R.; Lebois, Lauren A.M.; Lehto, Kelli; Levey, Daniel F.; Lewis, Catrin; Liberzon, Israel; Linnstaedt, Sarah D.; Logue, Mark W.; Lori, Adriana; Lu, Yi; Luft, Benjamin J.; Lupton, Michelle K.; Luykx, Jurjen J.; Makotkine, Iouri; Maples-Keller, Jessica L.; Marchese, Shelby; Marmar, Charles; Martin, Nicholas G.; Martínez-Levy, Gabriela A.; McAloney, Kerrie; McFarlane, Alexander; McLaughlin, Katie A.; McLean, Samuel A.; Medland, Sarah E.; Mehta, Divya; Meyers, Jacquelyn; Michopoulos, Vasiliki; Mikita, Elizabeth A.; Milani, Lili; Milberg, William; Miller, Mark W.; Morey, Rajendra A.; Morris, Charles Phillip; Mors, Ole; Mortensen, Preben Bo; Mufford, Mary S.; Nelson, Elliot C.; Nordentoft, Merete; Norman, Sonya B.; Nugent, Nicole R.; O’Donnell, Meaghan; Orcutt, Holly K.; Pan, Pedro M.; Panizzon, Matthew S.; Pathak, Gita A.; Peters, Edward S.; Peterson, Alan L.; Peverill, Matthew; Pietrzak, Robert H.; Polusny, Melissa A.; Porjesz, Bernice; Powers, Abigail; Qin, Xue Jun; Ratanatharathorn, Andrew; Risbrough, Victoria B.; Roberts, Andrea L.; Rothbaum, Alex O.; Rothbaum, Barbara O.; Roy-Byrne, Peter; Ruggiero, Kenneth J.; Rung, Ariane; Runz, Heiko; Rutten, Bart P.F.; de Viteri, Stacey Saenz; Salum, Giovanni Abrahão; Sampson, Laura; Sanchez, Sixto E.; Santoro, Marcos; Seah, Carina; Seedat, Soraya; Seng, Julia S.; Shabalin, Andrey; Sheerin, Christina M.; Silove, Derrick; Smith, Alicia K.; Smoller, Jordan W.; Sponheim, Scott R.; Stein, Dan J.; Stensland, Synne; Stevens, Jennifer S.; Sumner, Jennifer A.; Teicher, Martin H.; Thompson, Wesley K.; Tiwari, Arun K.; Trapido, Edward; Uddin, Monica; Ursano, Robert J.; Valdimarsdóttir, Unnur; Van Hooff, Miranda; Vermetten, Eric; Vinkers, Christiaan H.; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Waszczuk, Monika; Weber, Heike; Wendt, Frank R.; Werge, Thomas; Williams, Michelle A.; Williamson, Douglas E.; Winsvold, Bendik S.; Winternitz, Sherry; Wolf, Christiane; Wolf, Erika J.; Xia, Yan; Xiong, Ying; Yehuda, Rachel; Young, Keith A.; Young, Ross Mc D.; Zai, Clement C.; Zai, Gwyneth C.; Zervas, Mark; Zhao, Hongyu; Zoellner, Lori A.; Zwart, John Anker; deRoon-Cassini, Terri; van Rooij, Sanne J.H.; van den Heuvel, Leigh L.; Stein, Murray B.; Ressler, Kerry J.; Koenen, Karestan C.
I:
Nature Genetics, Bind 56, Nr. 5, 2024, s. 792-808.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Nievergelt, CM, Maihofer, AX, Atkinson, EG, Chen, CY, Choi, KW, Coleman, JRI, Daskalakis, NP, Duncan, LE, Polimanti, R, Aaronson, C, Amstadter, AB, Andersen, SB, Andreassen, OA, Arbisi, PA, Ashley-Koch, AE, Austin, SB, Avdibegoviç, E, Babić, D, Bacanu, SA, Baker, DG, Batzler, A, Beckham, JC, Belangero, S, Benjet, C, Bergner, C, Bierer, LM, Biernacka, JM, Bierut, LJ, Bisson, JI, Boks, MP, Bolger, EA, Brandolino, A, Breen, G, Bressan, RA, Bryant, RA, Bustamante, AC, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Børglum, AD, Børte, S, Cahn, L, Calabrese, JR, Caldas-de-Almeida, JM, Chatzinakos, C, Cheema, S, Clouston, SAP, Colodro-Conde, L, Coombes, BJ, Cruz-Fuentes, CS, Dale, AM, Dalvie, S, Davis, LK, Deckert, J, Delahanty, DL, Dennis, MF, Desarnaud, F, DiPietro, CP, Disner, SG, Docherty, AR, Domschke, K, Dyb, G, Kulenović, AD, Edenberg, HJ, Evans, A, Fabbri, C, Fani, N, Farrer, LA, Feder, A, Feeny, NC, Flory, JD, Forbes, D, Franz, CE, Galea, S, Garrett, ME, Gelaye, B, Gelernter, J, Geuze, E, Gillespie, CF, Goleva, SB, Gordon, SD, Goçi, A, Grasser, LR, Guindalini, C, Haas, M, Hagenaars, S, Hauser, MA, Heath, AC, Hemmings, SMJ, Hesselbrock, V, Hickie, IB, Hogan, K, Hougaard, DM, Huang, H, Huckins, LM, Hveem, K, Jakovljević, M, Javanbakht, A, Jenkins, GD, Johnson, J, Jones, I, Jovanovic, T
, Karstoft, KI, Kaufman, ML, Kennedy, JL, Kessler, RC, Khan, A, Kimbrel, NA, King, AP, Koen, N, Kotov, R, Kranzler, HR, Krebs, K, Kremen, WS, Kuan, PF, Lawford, BR, Lebois, LAM, Lehto, K, Levey, DF, Lewis, C, Liberzon, I, Linnstaedt, SD, Logue, MW, Lori, A, Lu, Y, Luft, BJ, Lupton, MK, Luykx, JJ, Makotkine, I, Maples-Keller, JL, Marchese, S, Marmar, C, Martin, NG, Martínez-Levy, GA, McAloney, K, McFarlane, A, McLaughlin, KA, McLean, SA, Medland, SE, Mehta, D, Meyers, J, Michopoulos, V, Mikita, EA, Milani, L, Milberg, W, Miller, MW, Morey, RA, Morris, CP, Mors, O, Mortensen, PB, Mufford, MS, Nelson, EC
, Nordentoft, M, Norman, SB, Nugent, NR, O’Donnell, M, Orcutt, HK, Pan, PM, Panizzon, MS, Pathak, GA, Peters, ES, Peterson, AL, Peverill, M, Pietrzak, RH, Polusny, MA, Porjesz, B, Powers, A, Qin, XJ, Ratanatharathorn, A, Risbrough, VB, Roberts, AL, Rothbaum, AO, Rothbaum, BO, Roy-Byrne, P, Ruggiero, KJ, Rung, A, Runz, H, Rutten, BPF, de Viteri, SS, Salum, GA, Sampson, L, Sanchez, SE, Santoro, M, Seah, C, Seedat, S, Seng, JS, Shabalin, A, Sheerin, CM, Silove, D, Smith, AK, Smoller, JW, Sponheim, SR, Stein, DJ, Stensland, S, Stevens, JS, Sumner, JA, Teicher, MH, Thompson, WK, Tiwari, AK, Trapido, E, Uddin, M, Ursano, RJ, Valdimarsdóttir, U, Van Hooff, M, Vermetten, E, Vinkers, CH, Voisey, J, Wang, Y, Wang, Z, Waszczuk, M, Weber, H, Wendt, FR
, Werge, T, Williams, MA, Williamson, DE, Winsvold, BS, Winternitz, S, Wolf, C, Wolf, EJ, Xia, Y, Xiong, Y, Yehuda, R, Young, KA, Young, RMD, Zai, CC, Zai, GC, Zervas, M, Zhao, H, Zoellner, LA, Zwart, JA, deRoon-Cassini, T, van Rooij, SJH, van den Heuvel, LL, Stein, MB, Ressler, KJ & Koenen, KC 2024, '
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder',
Nature Genetics, bind 56, nr. 5, s. 792-808.
https://doi.org/10.1038/s41588-024-01707-9APA
Nievergelt, C. M., Maihofer, A. X., Atkinson, E. G., Chen, C. Y., Choi, K. W., Coleman, J. R. I., Daskalakis, N. P., Duncan, L. E., Polimanti, R., Aaronson, C., Amstadter, A. B., Andersen, S. B., Andreassen, O. A., Arbisi, P. A., Ashley-Koch, A. E., Austin, S. B., Avdibegoviç, E., Babić, D., Bacanu, S. A., ... Koenen, K. C. (2024).
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.
Nature Genetics,
56(5), 792-808.
https://doi.org/10.1038/s41588-024-01707-9Vancouver
Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JRI o.a.
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.
Nature Genetics. 2024;56(5):792-808.
https://doi.org/10.1038/s41588-024-01707-9Author
Nievergelt, Caroline M. ; Maihofer, Adam X. ; Atkinson, Elizabeth G. ; Chen, Chia Yen ; Choi, Karmel W. ; Coleman, Jonathan R.I. ; Daskalakis, Nikolaos P. ; Duncan, Laramie E. ; Polimanti, Renato ; Aaronson, Cindy ; Amstadter, Ananda B. ; Andersen, Soren B. ; Andreassen, Ole A. ; Arbisi, Paul A. ; Ashley-Koch, Allison E. ; Austin, S. Bryn ; Avdibegoviç, Esmina ; Babić, Dragan ; Bacanu, Silviu Alin ; Baker, Dewleen G. ; Batzler, Anthony ; Beckham, Jean C. ; Belangero, Sintia ; Benjet, Corina ; Bergner, Carisa ; Bierer, Linda M. ; Biernacka, Joanna M. ; Bierut, Laura J. ; Bisson, Jonathan I. ; Boks, Marco P. ; Bolger, Elizabeth A. ; Brandolino, Amber ; Breen, Gerome ; Bressan, Rodrigo Affonseca ; Bryant, Richard A. ; Bustamante, Angela C. ; Bybjerg-Grauholm, Jonas ; Bækvad-Hansen, Marie ; Børglum, Anders D. ; Børte, Sigrid ; Cahn, Leah ; Calabrese, Joseph R. ; Caldas-de-Almeida, Jose Miguel ; Chatzinakos, Chris ; Cheema, Sheraz ; Clouston, Sean A.P. ; Colodro-Conde, Lucía ; Coombes, Brandon J. ; Cruz-Fuentes, Carlos S. ; Dale, Anders M. ; Dalvie, Shareefa ; Davis, Lea K. ; Deckert, Jürgen ; Delahanty, Douglas L. ; Dennis, Michelle F. ; Desarnaud, Frank ; DiPietro, Christopher P. ; Disner, Seth G. ; Docherty, Anna R. ; Domschke, Katharina ; Dyb, Grete ; Kulenović, Alma Džubur ; Edenberg, Howard J. ; Evans, Alexandra ; Fabbri, Chiara ; Fani, Negar ; Farrer, Lindsay A. ; Feder, Adriana ; Feeny, Norah C. ; Flory, Janine D. ; Forbes, David ; Franz, Carol E. ; Galea, Sandro ; Garrett, Melanie E. ; Gelaye, Bizu ; Gelernter, Joel ; Geuze, Elbert ; Gillespie, Charles F. ; Goleva, Slavina B. ; Gordon, Scott D. ; Goçi, Aferdita ; Grasser, Lana Ruvolo ; Guindalini, Camila ; Haas, Magali ; Hagenaars, Saskia ; Hauser, Michael A. ; Heath, Andrew C. ; Hemmings, Sian M.J. ; Hesselbrock, Victor ; Hickie, Ian B. ; Hogan, Kelleigh ; Hougaard, David Michael ; Huang, Hailiang ; Huckins, Laura M. ; Hveem, Kristian ; Jakovljević, Miro ; Javanbakht, Arash ; Jenkins, Gregory D. ; Johnson, Jessica ; Jones, Ian ; Jovanovic, Tanja ; Karstoft, Karen Inge ; Kaufman, Milissa L. ; Kennedy, James L. ; Kessler, Ronald C. ; Khan, Alaptagin ; Kimbrel, Nathan A. ; King, Anthony P. ; Koen, Nastassja ; Kotov, Roman ; Kranzler, Henry R. ; Krebs, Kristi ; Kremen, William S. ; Kuan, Pei Fen ; Lawford, Bruce R. ; Lebois, Lauren A.M. ; Lehto, Kelli ; Levey, Daniel F. ; Lewis, Catrin ; Liberzon, Israel ; Linnstaedt, Sarah D. ; Logue, Mark W. ; Lori, Adriana ; Lu, Yi ; Luft, Benjamin J. ; Lupton, Michelle K. ; Luykx, Jurjen J. ; Makotkine, Iouri ; Maples-Keller, Jessica L. ; Marchese, Shelby ; Marmar, Charles ; Martin, Nicholas G. ; Martínez-Levy, Gabriela A. ; McAloney, Kerrie ; McFarlane, Alexander ; McLaughlin, Katie A. ; McLean, Samuel A. ; Medland, Sarah E. ; Mehta, Divya ; Meyers, Jacquelyn ; Michopoulos, Vasiliki ; Mikita, Elizabeth A. ; Milani, Lili ; Milberg, William ; Miller, Mark W. ; Morey, Rajendra A. ; Morris, Charles Phillip ; Mors, Ole ; Mortensen, Preben Bo ; Mufford, Mary S. ; Nelson, Elliot C. ; Nordentoft, Merete ; Norman, Sonya B. ; Nugent, Nicole R. ; O’Donnell, Meaghan ; Orcutt, Holly K. ; Pan, Pedro M. ; Panizzon, Matthew S. ; Pathak, Gita A. ; Peters, Edward S. ; Peterson, Alan L. ; Peverill, Matthew ; Pietrzak, Robert H. ; Polusny, Melissa A. ; Porjesz, Bernice ; Powers, Abigail ; Qin, Xue Jun ; Ratanatharathorn, Andrew ; Risbrough, Victoria B. ; Roberts, Andrea L. ; Rothbaum, Alex O. ; Rothbaum, Barbara O. ; Roy-Byrne, Peter ; Ruggiero, Kenneth J. ; Rung, Ariane ; Runz, Heiko ; Rutten, Bart P.F. ; de Viteri, Stacey Saenz ; Salum, Giovanni Abrahão ; Sampson, Laura ; Sanchez, Sixto E. ; Santoro, Marcos ; Seah, Carina ; Seedat, Soraya ; Seng, Julia S. ; Shabalin, Andrey ; Sheerin, Christina M. ; Silove, Derrick ; Smith, Alicia K. ; Smoller, Jordan W. ; Sponheim, Scott R. ; Stein, Dan J. ; Stensland, Synne ; Stevens, Jennifer S. ; Sumner, Jennifer A. ; Teicher, Martin H. ; Thompson, Wesley K. ; Tiwari, Arun K. ; Trapido, Edward ; Uddin, Monica ; Ursano, Robert J. ; Valdimarsdóttir, Unnur ; Van Hooff, Miranda ; Vermetten, Eric ; Vinkers, Christiaan H. ; Voisey, Joanne ; Wang, Yunpeng ; Wang, Zhewu ; Waszczuk, Monika ; Weber, Heike ; Wendt, Frank R. ; Werge, Thomas ; Williams, Michelle A. ; Williamson, Douglas E. ; Winsvold, Bendik S. ; Winternitz, Sherry ; Wolf, Christiane ; Wolf, Erika J. ; Xia, Yan ; Xiong, Ying ; Yehuda, Rachel ; Young, Keith A. ; Young, Ross Mc D. ; Zai, Clement C. ; Zai, Gwyneth C. ; Zervas, Mark ; Zhao, Hongyu ; Zoellner, Lori A. ; Zwart, John Anker ; deRoon-Cassini, Terri ; van Rooij, Sanne J.H. ; van den Heuvel, Leigh L. ; Stein, Murray B. ; Ressler, Kerry J. ; Koenen, Karestan C. / Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. I: Nature Genetics. 2024 ; Bind 56, Nr. 5. s. 792-808.
Bibtex
@article{d82341793ba249718f267be0c2e60925,
title = "Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder",
abstract = "Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (for example, GRIA1, GRM8 and CACNA1E), developmental, axon guidance and transcription factors (for example, FOXP2, EFNA5 and DCC), synaptic structure and function genes (for example, PCLO, NCAM1 and PDE4B) and endocrine or immune regulators (for example, ESR1, TRAF3 and TANK). Additional top genes influence stress, immune, fear and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation.",
author = "Nievergelt, {Caroline M.} and Maihofer, {Adam X.} and Atkinson, {Elizabeth G.} and Chen, {Chia Yen} and Choi, {Karmel W.} and Coleman, {Jonathan R.I.} and Daskalakis, {Nikolaos P.} and Duncan, {Laramie E.} and Renato Polimanti and Cindy Aaronson and Amstadter, {Ananda B.} and Andersen, {Soren B.} and Andreassen, {Ole A.} and Arbisi, {Paul A.} and Ashley-Koch, {Allison E.} and Austin, {S. Bryn} and Esmina Avdibegovi{\c c} and Dragan Babi{\'c} and Bacanu, {Silviu Alin} and Baker, {Dewleen G.} and Anthony Batzler and Beckham, {Jean C.} and Sintia Belangero and Corina Benjet and Carisa Bergner and Bierer, {Linda M.} and Biernacka, {Joanna M.} and Bierut, {Laura J.} and Bisson, {Jonathan I.} and Boks, {Marco P.} and Bolger, {Elizabeth A.} and Amber Brandolino and Gerome Breen and Bressan, {Rodrigo Affonseca} and Bryant, {Richard A.} and Bustamante, {Angela C.} and Jonas Bybjerg-Grauholm and Marie B{\ae}kvad-Hansen and B{\o}rglum, {Anders D.} and Sigrid B{\o}rte and Leah Cahn and Calabrese, {Joseph R.} and Caldas-de-Almeida, {Jose Miguel} and Chris Chatzinakos and Sheraz Cheema and Clouston, {Sean A.P.} and Luc{\'i}a Colodro-Conde and Coombes, {Brandon J.} and Cruz-Fuentes, {Carlos S.} and Dale, {Anders M.} and Shareefa Dalvie and Davis, {Lea K.} and J{\"u}rgen Deckert and Delahanty, {Douglas L.} and Dennis, {Michelle F.} and Frank Desarnaud and DiPietro, {Christopher P.} and Disner, {Seth G.} and Docherty, {Anna R.} and Katharina Domschke and Grete Dyb and Kulenovi{\'c}, {Alma D{\v z}ubur} and Edenberg, {Howard J.} and Alexandra Evans and Chiara Fabbri and Negar Fani and Farrer, {Lindsay A.} and Adriana Feder and Feeny, {Norah C.} and Flory, {Janine D.} and David Forbes and Franz, {Carol E.} and Sandro Galea and Garrett, {Melanie E.} and Bizu Gelaye and Joel Gelernter and Elbert Geuze and Gillespie, {Charles F.} and Goleva, {Slavina B.} and Gordon, {Scott D.} and Aferdita Go{\c c}i and Grasser, {Lana Ruvolo} and Camila Guindalini and Magali Haas and Saskia Hagenaars and Hauser, {Michael A.} and Heath, {Andrew C.} and Hemmings, {Sian M.J.} and Victor Hesselbrock and Hickie, {Ian B.} and Kelleigh Hogan and Hougaard, {David Michael} and Hailiang Huang and Huckins, {Laura M.} and Kristian Hveem and Miro Jakovljevi{\'c} and Arash Javanbakht and Jenkins, {Gregory D.} and Jessica Johnson and Ian Jones and Tanja Jovanovic and Karstoft, {Karen Inge} and Kaufman, {Milissa L.} and Kennedy, {James L.} and Kessler, {Ronald C.} and Alaptagin Khan and Kimbrel, {Nathan A.} and King, {Anthony P.} and Nastassja Koen and Roman Kotov and Kranzler, {Henry R.} and Kristi Krebs and Kremen, {William S.} and Kuan, {Pei Fen} and Lawford, {Bruce R.} and Lebois, {Lauren A.M.} and Kelli Lehto and Levey, {Daniel F.} and Catrin Lewis and Israel Liberzon and Linnstaedt, {Sarah D.} and Logue, {Mark W.} and Adriana Lori and Yi Lu and Luft, {Benjamin J.} and Lupton, {Michelle K.} and Luykx, {Jurjen J.} and Iouri Makotkine and Maples-Keller, {Jessica L.} and Shelby Marchese and Charles Marmar and Martin, {Nicholas G.} and Mart{\'i}nez-Levy, {Gabriela A.} and Kerrie McAloney and Alexander McFarlane and McLaughlin, {Katie A.} and McLean, {Samuel A.} and Medland, {Sarah E.} and Divya Mehta and Jacquelyn Meyers and Vasiliki Michopoulos and Mikita, {Elizabeth A.} and Lili Milani and William Milberg and Miller, {Mark W.} and Morey, {Rajendra A.} and Morris, {Charles Phillip} and Ole Mors and Mortensen, {Preben Bo} and Mufford, {Mary S.} and Nelson, {Elliot C.} and Merete Nordentoft and Norman, {Sonya B.} and Nugent, {Nicole R.} and Meaghan O{\textquoteright}Donnell and Orcutt, {Holly K.} and Pan, {Pedro M.} and Panizzon, {Matthew S.} and Pathak, {Gita A.} and Peters, {Edward S.} and Peterson, {Alan L.} and Matthew Peverill and Pietrzak, {Robert H.} and Polusny, {Melissa A.} and Bernice Porjesz and Abigail Powers and Qin, {Xue Jun} and Andrew Ratanatharathorn and Risbrough, {Victoria B.} and Roberts, {Andrea L.} and Rothbaum, {Alex O.} and Rothbaum, {Barbara O.} and Peter Roy-Byrne and Ruggiero, {Kenneth J.} and Ariane Rung and Heiko Runz and Rutten, {Bart P.F.} and {de Viteri}, {Stacey Saenz} and Salum, {Giovanni Abrah{\~a}o} and Laura Sampson and Sanchez, {Sixto E.} and Marcos Santoro and Carina Seah and Soraya Seedat and Seng, {Julia S.} and Andrey Shabalin and Sheerin, {Christina M.} and Derrick Silove and Smith, {Alicia K.} and Smoller, {Jordan W.} and Sponheim, {Scott R.} and Stein, {Dan J.} and Synne Stensland and Stevens, {Jennifer S.} and Sumner, {Jennifer A.} and Teicher, {Martin H.} and Thompson, {Wesley K.} and Tiwari, {Arun K.} and Edward Trapido and Monica Uddin and Ursano, {Robert J.} and Unnur Valdimarsd{\'o}ttir and {Van Hooff}, Miranda and Eric Vermetten and Vinkers, {Christiaan H.} and Joanne Voisey and Yunpeng Wang and Zhewu Wang and Monika Waszczuk and Heike Weber and Wendt, {Frank R.} and Thomas Werge and Williams, {Michelle A.} and Williamson, {Douglas E.} and Winsvold, {Bendik S.} and Sherry Winternitz and Christiane Wolf and Wolf, {Erika J.} and Yan Xia and Ying Xiong and Rachel Yehuda and Young, {Keith A.} and Young, {Ross Mc D.} and Zai, {Clement C.} and Zai, {Gwyneth C.} and Mark Zervas and Hongyu Zhao and Zoellner, {Lori A.} and Zwart, {John Anker} and Terri deRoon-Cassini and {van Rooij}, {Sanne J.H.} and {van den Heuvel}, {Leigh L.} and Stein, {Murray B.} and Ressler, {Kerry J.} and Koenen, {Karestan C.}",
note = "Publisher Copyright: {\textcopyright} This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024.",
year = "2024",
doi = "10.1038/s41588-024-01707-9",
language = "English",
volume = "56",
pages = "792--808",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "5",
}
RIS
TY - JOUR
T1 - Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
AU - Nievergelt, Caroline M.
AU - Maihofer, Adam X.
AU - Atkinson, Elizabeth G.
AU - Chen, Chia Yen
AU - Choi, Karmel W.
AU - Coleman, Jonathan R.I.
AU - Daskalakis, Nikolaos P.
AU - Duncan, Laramie E.
AU - Polimanti, Renato
AU - Aaronson, Cindy
AU - Amstadter, Ananda B.
AU - Andersen, Soren B.
AU - Andreassen, Ole A.
AU - Arbisi, Paul A.
AU - Ashley-Koch, Allison E.
AU - Austin, S. Bryn
AU - Avdibegoviç, Esmina
AU - Babić, Dragan
AU - Bacanu, Silviu Alin
AU - Baker, Dewleen G.
AU - Batzler, Anthony
AU - Beckham, Jean C.
AU - Belangero, Sintia
AU - Benjet, Corina
AU - Bergner, Carisa
AU - Bierer, Linda M.
AU - Biernacka, Joanna M.
AU - Bierut, Laura J.
AU - Bisson, Jonathan I.
AU - Boks, Marco P.
AU - Bolger, Elizabeth A.
AU - Brandolino, Amber
AU - Breen, Gerome
AU - Bressan, Rodrigo Affonseca
AU - Bryant, Richard A.
AU - Bustamante, Angela C.
AU - Bybjerg-Grauholm, Jonas
AU - Bækvad-Hansen, Marie
AU - Børglum, Anders D.
AU - Børte, Sigrid
AU - Cahn, Leah
AU - Calabrese, Joseph R.
AU - Caldas-de-Almeida, Jose Miguel
AU - Chatzinakos, Chris
AU - Cheema, Sheraz
AU - Clouston, Sean A.P.
AU - Colodro-Conde, Lucía
AU - Coombes, Brandon J.
AU - Cruz-Fuentes, Carlos S.
AU - Dale, Anders M.
AU - Dalvie, Shareefa
AU - Davis, Lea K.
AU - Deckert, Jürgen
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N1 - Publisher Copyright:
© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024.
PY - 2024
Y1 - 2024
N2 - Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (for example, GRIA1, GRM8 and CACNA1E), developmental, axon guidance and transcription factors (for example, FOXP2, EFNA5 and DCC), synaptic structure and function genes (for example, PCLO, NCAM1 and PDE4B) and endocrine or immune regulators (for example, ESR1, TRAF3 and TANK). Additional top genes influence stress, immune, fear and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation.
AB - Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (for example, GRIA1, GRM8 and CACNA1E), developmental, axon guidance and transcription factors (for example, FOXP2, EFNA5 and DCC), synaptic structure and function genes (for example, PCLO, NCAM1 and PDE4B) and endocrine or immune regulators (for example, ESR1, TRAF3 and TANK). Additional top genes influence stress, immune, fear and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation.
U2 - 10.1038/s41588-024-01707-9
DO - 10.1038/s41588-024-01707-9
M3 - Journal article
C2 - 38637617
AN - SCOPUS:85190650468
VL - 56
SP - 792
EP - 808
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 5
ER -
