Genome sequence of the Brown Norway rat yields insights into mammalian evolution
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution. / Gibbs, Richard A; Weinstock, George M; Metzker, Michael L; Muzny, Donna M; Sodergren, Erica J; Scherer, Steven; Scott, Graham; Steffen, David; Worley, Kim C; Burch, Paula E; Okwuonu, Geoffrey; Hines, Sandra; Lewis, Lora; DeRamo, Christine; Delgado, Oliver; Dugan-Rocha, Shannon; Miner, George; Morgan, Margaret; Hawes, Alicia; Gill, Rachel; Celera; Holt, Robert A; Adams, Mark D; Amanatides, Peter G; Baden-Tillson, Holly; Barnstead, Mary; Chin, Soo; Evans, Cheryl A; Ferriera, Steve; Fosler, Carl; Glodek, Anna; Gu, Zhiping; Jennings, Don; Kraft, Cheryl L; Nguyen, Trixie; Pfannkoch, Cynthia M; Sitter, Cynthia; Sutton, Granger G; Venter, J Craig; Woodage, Trevor; Smith, Douglas; Lee, Hong-Mei; Gustafson, Erik; Cahill, Patrick; Kana, Arnold; Doucette-Stamm, Lynn; Weinstock, Keith; Fechtel, Kim; Weiss, Robert B; Arumugam, Manimozhiyan; Rat Genome Sequencing Project Consortium.
I: Nature, Bind 428, Nr. 6982, 2004, s. 493-521.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Genome sequence of the Brown Norway rat yields insights into mammalian evolution
AU - Gibbs, Richard A
AU - Weinstock, George M
AU - Metzker, Michael L
AU - Muzny, Donna M
AU - Sodergren, Erica J
AU - Scherer, Steven
AU - Scott, Graham
AU - Steffen, David
AU - Worley, Kim C
AU - Burch, Paula E
AU - Okwuonu, Geoffrey
AU - Hines, Sandra
AU - Lewis, Lora
AU - DeRamo, Christine
AU - Delgado, Oliver
AU - Dugan-Rocha, Shannon
AU - Miner, George
AU - Morgan, Margaret
AU - Hawes, Alicia
AU - Gill, Rachel
AU - Celera, null
AU - Holt, Robert A
AU - Adams, Mark D
AU - Amanatides, Peter G
AU - Baden-Tillson, Holly
AU - Barnstead, Mary
AU - Chin, Soo
AU - Evans, Cheryl A
AU - Ferriera, Steve
AU - Fosler, Carl
AU - Glodek, Anna
AU - Gu, Zhiping
AU - Jennings, Don
AU - Kraft, Cheryl L
AU - Nguyen, Trixie
AU - Pfannkoch, Cynthia M
AU - Sitter, Cynthia
AU - Sutton, Granger G
AU - Venter, J Craig
AU - Woodage, Trevor
AU - Smith, Douglas
AU - Lee, Hong-Mei
AU - Gustafson, Erik
AU - Cahill, Patrick
AU - Kana, Arnold
AU - Doucette-Stamm, Lynn
AU - Weinstock, Keith
AU - Fechtel, Kim
AU - Weiss, Robert B
AU - Arumugam, Manimozhiyan
AU - Rat Genome Sequencing Project Consortium
PY - 2004
Y1 - 2004
N2 - The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.
AB - The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.
KW - Animals
KW - Base Composition
KW - Centromere
KW - Chromosomes, Mammalian
KW - CpG Islands
KW - DNA Transposable Elements
KW - DNA, Mitochondrial
KW - Evolution, Molecular
KW - Gene Duplication
KW - Genome
KW - Genomics
KW - Humans
KW - Introns
KW - Male
KW - Mice
KW - Models, Molecular
KW - Mutagenesis
KW - Polymorphism, Single Nucleotide
KW - RNA Splice Sites
KW - RNA, Untranslated
KW - Rats
KW - Rats, Inbred BN
KW - Regulatory Sequences, Nucleic Acid
KW - Retroelements
KW - Sequence Analysis, DNA
KW - Telomere
U2 - 10.1038/nature02426
DO - 10.1038/nature02426
M3 - Journal article
C2 - 15057822
VL - 428
SP - 493
EP - 521
JO - Nature
JF - Nature
SN - 0028-0836
IS - 6982
ER -
ID: 43976543