Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes

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Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. / Machiela, Mitchell J.; Lan, Qing; Slager, Susan L.; Vermeulen, Roel C.H.; Teras, Lauren R.; Camp, Nicola J.; Cerhan, James R.; Spinelli, John J.; Wang, Sophia S.; Nieters, Alexandra; Vijai, Joseph; Yeager, Meredith; Wang, Zhaoming; Ghesquières, Hervé; McKay, James; Conde, Lucia; de Bakker, Paul I.W.; Cox, David G.; Burdett, Laurie; Monnereau, Alain; Flowers, Christopher R.; De Roos, Anneclaire J.; Brooks-Wilson, Angela R.; Giles, Graham G.; Melbye, Mads; Gu, Jian; Jackson, Rebecca D.; Kane, Eleanor; Purdue, Mark P.; Vajdic, Claire M.; Albanes, Demetrius; Kelly, Rachel S.; Zucca, Mariagrazia; Bertrand, Kimberly A.; Zeleniuch-Jacquotte, Anne; Lawrence, Charles; Hutchinson, Amy; Zhi, Degui; Habermann, Thomas M.; Link, Brian K.; Novak, Anne J.; Dogan, Ahmet; Asmann, Yan W.; Liebow, Mark; Thompson, Carrie A.; Ansell, Stephen M.; Witzig, Thomas E.; Tilly, Hervé; Hjalgrim, Henrik; Tjønneland, Anne.

I: Human Molecular Genetics, Bind 25, Nr. 8, 15.04.2016, s. 1663-1676.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Machiela, MJ, Lan, Q, Slager, SL, Vermeulen, RCH, Teras, LR, Camp, NJ, Cerhan, JR, Spinelli, JJ, Wang, SS, Nieters, A, Vijai, J, Yeager, M, Wang, Z, Ghesquières, H, McKay, J, Conde, L, de Bakker, PIW, Cox, DG, Burdett, L, Monnereau, A, Flowers, CR, De Roos, AJ, Brooks-Wilson, AR, Giles, GG, Melbye, M, Gu, J, Jackson, RD, Kane, E, Purdue, MP, Vajdic, CM, Albanes, D, Kelly, RS, Zucca, M, Bertrand, KA, Zeleniuch-Jacquotte, A, Lawrence, C, Hutchinson, A, Zhi, D, Habermann, TM, Link, BK, Novak, AJ, Dogan, A, Asmann, YW, Liebow, M, Thompson, CA, Ansell, SM, Witzig, TE, Tilly, H, Hjalgrim, H & Tjønneland, A 2016, 'Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes', Human Molecular Genetics, bind 25, nr. 8, s. 1663-1676. https://doi.org/10.1093/hmg/ddw027

APA

Machiela, M. J., Lan, Q., Slager, S. L., Vermeulen, R. C. H., Teras, L. R., Camp, N. J., Cerhan, J. R., Spinelli, J. J., Wang, S. S., Nieters, A., Vijai, J., Yeager, M., Wang, Z., Ghesquières, H., McKay, J., Conde, L., de Bakker, P. I. W., Cox, D. G., Burdett, L., ... Tjønneland, A. (2016). Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. Human Molecular Genetics, 25(8), 1663-1676. https://doi.org/10.1093/hmg/ddw027

Vancouver

Machiela MJ, Lan Q, Slager SL, Vermeulen RCH, Teras LR, Camp NJ o.a. Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. Human Molecular Genetics. 2016 apr. 15;25(8):1663-1676. https://doi.org/10.1093/hmg/ddw027

Author

Machiela, Mitchell J. ; Lan, Qing ; Slager, Susan L. ; Vermeulen, Roel C.H. ; Teras, Lauren R. ; Camp, Nicola J. ; Cerhan, James R. ; Spinelli, John J. ; Wang, Sophia S. ; Nieters, Alexandra ; Vijai, Joseph ; Yeager, Meredith ; Wang, Zhaoming ; Ghesquières, Hervé ; McKay, James ; Conde, Lucia ; de Bakker, Paul I.W. ; Cox, David G. ; Burdett, Laurie ; Monnereau, Alain ; Flowers, Christopher R. ; De Roos, Anneclaire J. ; Brooks-Wilson, Angela R. ; Giles, Graham G. ; Melbye, Mads ; Gu, Jian ; Jackson, Rebecca D. ; Kane, Eleanor ; Purdue, Mark P. ; Vajdic, Claire M. ; Albanes, Demetrius ; Kelly, Rachel S. ; Zucca, Mariagrazia ; Bertrand, Kimberly A. ; Zeleniuch-Jacquotte, Anne ; Lawrence, Charles ; Hutchinson, Amy ; Zhi, Degui ; Habermann, Thomas M. ; Link, Brian K. ; Novak, Anne J. ; Dogan, Ahmet ; Asmann, Yan W. ; Liebow, Mark ; Thompson, Carrie A. ; Ansell, Stephen M. ; Witzig, Thomas E. ; Tilly, Hervé ; Hjalgrim, Henrik ; Tjønneland, Anne. / Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. I: Human Molecular Genetics. 2016 ; Bind 25, Nr. 8. s. 1663-1676.

Bibtex

@article{6cd7f64230e347fe8dcf81de9bc71422,
title = "Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes",
abstract = "Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk.We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82, P-value = 8.5 × 10-5]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51, P-value = 4.0 × 10-10). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere lengthmay increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk.",
author = "Machiela, {Mitchell J.} and Qing Lan and Slager, {Susan L.} and Vermeulen, {Roel C.H.} and Teras, {Lauren R.} and Camp, {Nicola J.} and Cerhan, {James R.} and Spinelli, {John J.} and Wang, {Sophia S.} and Alexandra Nieters and Joseph Vijai and Meredith Yeager and Zhaoming Wang and Herv{\'e} Ghesqui{\`e}res and James McKay and Lucia Conde and {de Bakker}, {Paul I.W.} and Cox, {David G.} and Laurie Burdett and Alain Monnereau and Flowers, {Christopher R.} and {De Roos}, {Anneclaire J.} and Brooks-Wilson, {Angela R.} and Giles, {Graham G.} and Mads Melbye and Jian Gu and Jackson, {Rebecca D.} and Eleanor Kane and Purdue, {Mark P.} and Vajdic, {Claire M.} and Demetrius Albanes and Kelly, {Rachel S.} and Mariagrazia Zucca and Bertrand, {Kimberly A.} and Anne Zeleniuch-Jacquotte and Charles Lawrence and Amy Hutchinson and Degui Zhi and Habermann, {Thomas M.} and Link, {Brian K.} and Novak, {Anne J.} and Ahmet Dogan and Asmann, {Yan W.} and Mark Liebow and Thompson, {Carrie A.} and Ansell, {Stephen M.} and Witzig, {Thomas E.} and Herv{\'e} Tilly and Henrik Hjalgrim and Anne Tj{\o}nneland",
year = "2016",
month = apr,
day = "15",
doi = "10.1093/hmg/ddw027",
language = "English",
volume = "25",
pages = "1663--1676",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes

AU - Machiela, Mitchell J.

AU - Lan, Qing

AU - Slager, Susan L.

AU - Vermeulen, Roel C.H.

AU - Teras, Lauren R.

AU - Camp, Nicola J.

AU - Cerhan, James R.

AU - Spinelli, John J.

AU - Wang, Sophia S.

AU - Nieters, Alexandra

AU - Vijai, Joseph

AU - Yeager, Meredith

AU - Wang, Zhaoming

AU - Ghesquières, Hervé

AU - McKay, James

AU - Conde, Lucia

AU - de Bakker, Paul I.W.

AU - Cox, David G.

AU - Burdett, Laurie

AU - Monnereau, Alain

AU - Flowers, Christopher R.

AU - De Roos, Anneclaire J.

AU - Brooks-Wilson, Angela R.

AU - Giles, Graham G.

AU - Melbye, Mads

AU - Gu, Jian

AU - Jackson, Rebecca D.

AU - Kane, Eleanor

AU - Purdue, Mark P.

AU - Vajdic, Claire M.

AU - Albanes, Demetrius

AU - Kelly, Rachel S.

AU - Zucca, Mariagrazia

AU - Bertrand, Kimberly A.

AU - Zeleniuch-Jacquotte, Anne

AU - Lawrence, Charles

AU - Hutchinson, Amy

AU - Zhi, Degui

AU - Habermann, Thomas M.

AU - Link, Brian K.

AU - Novak, Anne J.

AU - Dogan, Ahmet

AU - Asmann, Yan W.

AU - Liebow, Mark

AU - Thompson, Carrie A.

AU - Ansell, Stephen M.

AU - Witzig, Thomas E.

AU - Tilly, Hervé

AU - Hjalgrim, Henrik

AU - Tjønneland, Anne

PY - 2016/4/15

Y1 - 2016/4/15

N2 - Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk.We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82, P-value = 8.5 × 10-5]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51, P-value = 4.0 × 10-10). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere lengthmay increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk.

AB - Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk.We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82, P-value = 8.5 × 10-5]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51, P-value = 4.0 × 10-10). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere lengthmay increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk.

U2 - 10.1093/hmg/ddw027

DO - 10.1093/hmg/ddw027

M3 - Journal article

C2 - 27008888

AN - SCOPUS:84963721851

VL - 25

SP - 1663

EP - 1676

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 8

ER -

ID: 257835419