Genetic risk score based on obesity-related genes and progression in weight loss after bariatric surgery: a 60-month follow-up study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: Obesity is a polygenic multifactorial disease. Recent genome-wide association studies have identified several common loci associated with obesity-related phenotypes. Bariatric surgery (BS) is the most effective long-term treatment for patients with severe obesity. The huge variability in BS outcomes between patients suggests a moderating effect of several factors, including the genetic architecture of the patients. Objective: To examine the role of a genetic risk score (GRS) based on 7 polymorphisms in 5 obesity-candidate genes (FTO, MC4R, SIRT1, LEP, and LEPR) on weight loss after BS. Setting: University hospital in Spain. Methods: We evaluated a cohort of 104 patients with severe obesity submitted to BS (Roux-en-Y gastric bypass or sleeve gastrectomy) followed up for >60 months (lost to follow-up, 19.23%). A GRS was calculated for each patient, considering the number of carried risk alleles for the analyzed genes. During the postoperative period, the percentage of excess weight loss total weight loss and changes in body mass index were evaluated. Generalized estimating equation models were used for the prospective analysis of the variation of these variables in relation to the GRS. Results: The longitudinal model showed a significant effect of the GRS on the percentage of excess weight loss (P = 1.5 × 10–5), percentage of total weight loss (P = 3.1 × 10–8), and change in body mass index (P = 7.8 × 10–16) over time. Individuals with a low GRS seemed to experience better outcomes at 24 and 60 months after surgery than those with a higher GRS. Conclusion: The use of the GRS in considering the polygenic nature of obesity seems to be a useful tool to better understand the outcome of patients with obesity after BS.
Originalsprog | Engelsk |
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Tidsskrift | Surgery for Obesity and Related Diseases |
ISSN | 1550-7289 |
DOI | |
Status | Accepteret/In press - 2024 |
Bibliografisk note
Funding Information:
This study was supported by grants from the \u201CPla Estrat\u00E8gic de Recerca i Innovaci\u00F3 en Salut\u201D (PERIS) (2016\u20132020, SLT002/16/00497), the Instituto de Salud Carlos III (PI18/00964 and PI21/00462; Fondos FEDER \u201CUna manera de hacer Europa\u201D), and the Comissionat per a Universitats i Recerca of the Generalitat de Catalunya (2021SGR00706, 2021SGR01421, and 2021SGR00703). Patricia Mas-Bermejo was funded by the Ph.D. scholarship program FI-SDUR (2021-FISDU-00032) from Agencia de Gesti\u00F3n de Ayudas Universitarias y de Investigaci\u00F3n (AGAUR).
Funding Information:
Funding : This study was supported by grants from the \u201CPla Estrat\u00E8gic de Recerca i Innovaci\u00F3 en Salut\u201D (PERIS) 2016\u20132020 (SLT002/16/00497), the Instituto de Salud Carlos III (PI18/00964 and PI21/00462; Fondos FEDER \u201CUna manera de hacer Europa\u201D) and the Comissionat per a Universitats i Recerca of the Generalitat de Catalunya (2021SGR00706, 2021SGR01421 and 2021SGR00703). PMB was funded by the PhD scholarship program FI-SDUR (2021-FISDU-00032) from Agencia de Gesti\u00F3n de Ayudas Universitarias y de Investigaci\u00F3n (AGAUR).
Publisher Copyright:
© 2024 American Society for Metabolic and Bariatric Surgery
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