Genetic risk score based on obesity-related genes and progression in weight loss after bariatric surgery: a 60-month follow-up study
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Genetic risk score based on obesity-related genes and progression in weight loss after bariatric surgery : a 60-month follow-up study. / Mas-Bermejo, Patricia; Azcona-Granada, Natalia; Peña, Elionora; Lecube, Albert; Ciudin, Andreea; Simó, Rafael; Luna, Alexis; Rigla, Mercedes; Arenas, Concepción; Caixàs, Assumpta; Rosa, Araceli.
I: Surgery for Obesity and Related Diseases, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Genetic risk score based on obesity-related genes and progression in weight loss after bariatric surgery
T2 - a 60-month follow-up study
AU - Mas-Bermejo, Patricia
AU - Azcona-Granada, Natalia
AU - Peña, Elionora
AU - Lecube, Albert
AU - Ciudin, Andreea
AU - Simó, Rafael
AU - Luna, Alexis
AU - Rigla, Mercedes
AU - Arenas, Concepción
AU - Caixàs, Assumpta
AU - Rosa, Araceli
N1 - Publisher Copyright: © 2024 American Society for Metabolic and Bariatric Surgery
PY - 2024
Y1 - 2024
N2 - Background: Obesity is a polygenic multifactorial disease. Recent genome-wide association studies have identified several common loci associated with obesity-related phenotypes. Bariatric surgery (BS) is the most effective long-term treatment for patients with severe obesity. The huge variability in BS outcomes between patients suggests a moderating effect of several factors, including the genetic architecture of the patients. Objective: To examine the role of a genetic risk score (GRS) based on 7 polymorphisms in 5 obesity-candidate genes (FTO, MC4R, SIRT1, LEP, and LEPR) on weight loss after BS. Setting: University hospital in Spain. Methods: We evaluated a cohort of 104 patients with severe obesity submitted to BS (Roux-en-Y gastric bypass or sleeve gastrectomy) followed up for >60 months (lost to follow-up, 19.23%). A GRS was calculated for each patient, considering the number of carried risk alleles for the analyzed genes. During the postoperative period, the percentage of excess weight loss total weight loss and changes in body mass index were evaluated. Generalized estimating equation models were used for the prospective analysis of the variation of these variables in relation to the GRS. Results: The longitudinal model showed a significant effect of the GRS on the percentage of excess weight loss (P = 1.5 × 10–5), percentage of total weight loss (P = 3.1 × 10–8), and change in body mass index (P = 7.8 × 10–16) over time. Individuals with a low GRS seemed to experience better outcomes at 24 and 60 months after surgery than those with a higher GRS. Conclusion: The use of the GRS in considering the polygenic nature of obesity seems to be a useful tool to better understand the outcome of patients with obesity after BS.
AB - Background: Obesity is a polygenic multifactorial disease. Recent genome-wide association studies have identified several common loci associated with obesity-related phenotypes. Bariatric surgery (BS) is the most effective long-term treatment for patients with severe obesity. The huge variability in BS outcomes between patients suggests a moderating effect of several factors, including the genetic architecture of the patients. Objective: To examine the role of a genetic risk score (GRS) based on 7 polymorphisms in 5 obesity-candidate genes (FTO, MC4R, SIRT1, LEP, and LEPR) on weight loss after BS. Setting: University hospital in Spain. Methods: We evaluated a cohort of 104 patients with severe obesity submitted to BS (Roux-en-Y gastric bypass or sleeve gastrectomy) followed up for >60 months (lost to follow-up, 19.23%). A GRS was calculated for each patient, considering the number of carried risk alleles for the analyzed genes. During the postoperative period, the percentage of excess weight loss total weight loss and changes in body mass index were evaluated. Generalized estimating equation models were used for the prospective analysis of the variation of these variables in relation to the GRS. Results: The longitudinal model showed a significant effect of the GRS on the percentage of excess weight loss (P = 1.5 × 10–5), percentage of total weight loss (P = 3.1 × 10–8), and change in body mass index (P = 7.8 × 10–16) over time. Individuals with a low GRS seemed to experience better outcomes at 24 and 60 months after surgery than those with a higher GRS. Conclusion: The use of the GRS in considering the polygenic nature of obesity seems to be a useful tool to better understand the outcome of patients with obesity after BS.
KW - Bariatric surgery
KW - Genetic risk score
KW - Long-term follow-up
KW - Obesity
KW - Weight loss
U2 - 10.1016/j.soard.2024.04.002
DO - 10.1016/j.soard.2024.04.002
M3 - Journal article
C2 - 38744640
AN - SCOPUS:85192834441
JO - Surgery for Obesity and Related Diseases
JF - Surgery for Obesity and Related Diseases
SN - 1550-7289
ER -
ID: 393273169