Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population
Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. / Robinson, Elise B; St Pourcain, Beate; Anttila, Verneri; Kosmicki, Jack A; Bulik-Sullivan, Brendan; Grove, Jakob; Maller, Julian; Samocha, Kaitlin E; Sanders, Jan-Stephan F; Ripke, Stephan; Martin, Joanna; Hollegaard, Mads V; Werge, Thomas; Hougaard, David M.; Neale, Benjamin M; Evans, David M; Skuse, David; Mortensen, Preben Bo; Børglum, Anders D; Ronald, Angelica; Smith, George Davey; Daly, Mark J; iPSYCH-SSI-Broad Autism Group.
I: Nature Genetics, Bind 48, Nr. 5, 2016, s. 552-5.Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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TY - JOUR
T1 - Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population
AU - Robinson, Elise B
AU - St Pourcain, Beate
AU - Anttila, Verneri
AU - Kosmicki, Jack A
AU - Bulik-Sullivan, Brendan
AU - Grove, Jakob
AU - Maller, Julian
AU - Samocha, Kaitlin E
AU - Sanders, Jan-Stephan F
AU - Ripke, Stephan
AU - Martin, Joanna
AU - Hollegaard, Mads V
AU - Werge, Thomas
AU - Hougaard, David M.
AU - Neale, Benjamin M
AU - Evans, David M
AU - Skuse, David
AU - Mortensen, Preben Bo
AU - Børglum, Anders D
AU - Ronald, Angelica
AU - Smith, George Davey
AU - Daly, Mark J
AU - iPSYCH-SSI-Broad Autism Group
PY - 2016
Y1 - 2016
N2 - Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortium and population-based resources (total n > 38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology.
AB - Almost all genetic risk factors for autism spectrum disorders (ASDs) can be found in the general population, but the effects of this risk are unclear in people not ascertained for neuropsychiatric symptoms. Using several large ASD consortium and population-based resources (total n > 38,000), we find genome-wide genetic links between ASDs and typical variation in social behavior and adaptive functioning. This finding is evidenced through both LD score correlation and de novo variant analysis, indicating that multiple types of genetic risk for ASDs influence a continuum of behavioral and developmental traits, the severe tail of which can result in diagnosis with an ASD or other neuropsychiatric disorder. A continuum model should inform the design and interpretation of studies of neuropsychiatric disease biology.
KW - Journal Article
U2 - 10.1038/ng.3529
DO - 10.1038/ng.3529
M3 - Letter
C2 - 26998691
VL - 48
SP - 552
EP - 555
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 5
ER -
ID: 177068172