Genetic predisposition to long telomeres is associated with increased mortality after melanoma: a study of 2101 melanoma patients from hospital clinics and the general population
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Genetic predisposition to long telomeres is associated with increased mortality after melanoma : a study of 2101 melanoma patients from hospital clinics and the general population. / Ismail, Hafsa; Helby, Jens; Hölmich, Lisbet R; Chakera, Annette H; Bastholt, Lars; Klyver, Helle; Sjøgren, Pia; Schmidt, Henrik; Schöllhammer, Liv; Nordestgaard, Børge G; Bojesen, Stig E.
I: Pigment Cell & Melanoma Research, Bind 34, Nr. 5, 2021, s. 946-954.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Genetic predisposition to long telomeres is associated with increased mortality after melanoma
T2 - a study of 2101 melanoma patients from hospital clinics and the general population
AU - Ismail, Hafsa
AU - Helby, Jens
AU - Hölmich, Lisbet R
AU - Chakera, Annette H
AU - Bastholt, Lars
AU - Klyver, Helle
AU - Sjøgren, Pia
AU - Schmidt, Henrik
AU - Schöllhammer, Liv
AU - Nordestgaard, Børge G
AU - Bojesen, Stig E
N1 - This article is protected by copyright. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Whether there is an association between measured and genetically predicted telomere length and melanoma mortality is unclear. We tested the hypotheses that measured and genetically predicted telomere length are associated with mortality after a melanoma diagnosis. We followed 2101patients with melanoma from hospital clinics and the general population for risk of death for up to 26 years. All had telomere length measured in DNA from leukocytes and 2052 of these were genotyped for the three single nucleotide polymorphisms rs7726159 (TERT), rs1317082 (TERC) and rs2487999 (OBFC1);all three genotypes are associated with telomere length, and combined into an allele count from 0 to 6. For each telomere-lengthening allele, the hazard ratios (HR) for mortality in the age-adjusted and multivariable adjusted Cox analysis were 1.12 (95% confidence interval: 1.02 - 1.23) and 1.11 (1.01 - 1.23).However, for each standard deviation increase in measured telomere length, HR for mortality was 0.97 (0.88 - 1.08). In conclusion, in more than 2000 melanoma patients from hospital clinics and from the general population, genetically predicted long telomeres were associated with increased mortality, but measured leukocyte telomere length was not.
AB - Whether there is an association between measured and genetically predicted telomere length and melanoma mortality is unclear. We tested the hypotheses that measured and genetically predicted telomere length are associated with mortality after a melanoma diagnosis. We followed 2101patients with melanoma from hospital clinics and the general population for risk of death for up to 26 years. All had telomere length measured in DNA from leukocytes and 2052 of these were genotyped for the three single nucleotide polymorphisms rs7726159 (TERT), rs1317082 (TERC) and rs2487999 (OBFC1);all three genotypes are associated with telomere length, and combined into an allele count from 0 to 6. For each telomere-lengthening allele, the hazard ratios (HR) for mortality in the age-adjusted and multivariable adjusted Cox analysis were 1.12 (95% confidence interval: 1.02 - 1.23) and 1.11 (1.01 - 1.23).However, for each standard deviation increase in measured telomere length, HR for mortality was 0.97 (0.88 - 1.08). In conclusion, in more than 2000 melanoma patients from hospital clinics and from the general population, genetically predicted long telomeres were associated with increased mortality, but measured leukocyte telomere length was not.
U2 - 10.1111/pcmr.12971
DO - 10.1111/pcmr.12971
M3 - Journal article
C2 - 33749133
VL - 34
SP - 946
EP - 954
JO - Pigment Cell & Melanoma Research
JF - Pigment Cell & Melanoma Research
SN - 1755-1471
IS - 5
ER -
ID: 260665137