Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots

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Standard

Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots. / Albiñana, Clara; Zhu, Zhihong; Borbye-Lorenzen, Nis; Boelt, Sanne Grundvad; Cohen, Arieh S.; Skogstrand, Kristin; Wray, Naomi R.; Revez, Joana A.; Privé, Florian; Petersen, Liselotte V.; Bulik, Cynthia M.; Plana-Ripoll, Oleguer; Musliner, Katherine L.; Agerbo, Esben; Børglum, Anders D.; Hougaard, David M.; Nordentoft, Merete; Werge, Thomas; Mortensen, Preben Bo; Vilhjálmsson, Bjarni J.; McGrath, John J.

I: Nature Communications, Bind 14, 852, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Albiñana, C, Zhu, Z, Borbye-Lorenzen, N, Boelt, SG, Cohen, AS, Skogstrand, K, Wray, NR, Revez, JA, Privé, F, Petersen, LV, Bulik, CM, Plana-Ripoll, O, Musliner, KL, Agerbo, E, Børglum, AD, Hougaard, DM, Nordentoft, M, Werge, T, Mortensen, PB, Vilhjálmsson, BJ & McGrath, JJ 2023, 'Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots', Nature Communications, bind 14, 852. https://doi.org/10.1038/s41467-023-36392-5

APA

Albiñana, C., Zhu, Z., Borbye-Lorenzen, N., Boelt, S. G., Cohen, A. S., Skogstrand, K., Wray, N. R., Revez, J. A., Privé, F., Petersen, L. V., Bulik, C. M., Plana-Ripoll, O., Musliner, K. L., Agerbo, E., Børglum, A. D., Hougaard, D. M., Nordentoft, M., Werge, T., Mortensen, P. B., ... McGrath, J. J. (2023). Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots. Nature Communications, 14, [852]. https://doi.org/10.1038/s41467-023-36392-5

Vancouver

Albiñana C, Zhu Z, Borbye-Lorenzen N, Boelt SG, Cohen AS, Skogstrand K o.a. Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots. Nature Communications. 2023;14. 852. https://doi.org/10.1038/s41467-023-36392-5

Author

Albiñana, Clara ; Zhu, Zhihong ; Borbye-Lorenzen, Nis ; Boelt, Sanne Grundvad ; Cohen, Arieh S. ; Skogstrand, Kristin ; Wray, Naomi R. ; Revez, Joana A. ; Privé, Florian ; Petersen, Liselotte V. ; Bulik, Cynthia M. ; Plana-Ripoll, Oleguer ; Musliner, Katherine L. ; Agerbo, Esben ; Børglum, Anders D. ; Hougaard, David M. ; Nordentoft, Merete ; Werge, Thomas ; Mortensen, Preben Bo ; Vilhjálmsson, Bjarni J. ; McGrath, John J. / Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots. I: Nature Communications. 2023 ; Bind 14.

Bibtex

@article{1490c086915843fe98bff09dc2d09d0e,
title = "Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots",
abstract = "The vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of which are in or close to the GC gene, with fine-mapping identifying 2 missense variants on chromosomes 12 and 17 (within SH2B3 and GSDMA, respectively). When adjusted for GC haplotypes, we find 15 independent loci distributed over 10 chromosomes. Mendelian randomization analyses identify a unidirectional effect of higher DBP concentration and (a) higher 25-hydroxyvitamin D concentration, and (b) a reduced risk of multiple sclerosis and rheumatoid arthritis. A phenome-wide association study confirms that higher DBP concentration is associated with a reduced risk of vitamin D deficiency. Our findings provide valuable insights into the influence of DBP on vitamin D status and a range of health outcomes.",
author = "Clara Albi{\~n}ana and Zhihong Zhu and Nis Borbye-Lorenzen and Boelt, {Sanne Grundvad} and Cohen, {Arieh S.} and Kristin Skogstrand and Wray, {Naomi R.} and Revez, {Joana A.} and Florian Priv{\'e} and Petersen, {Liselotte V.} and Bulik, {Cynthia M.} and Oleguer Plana-Ripoll and Musliner, {Katherine L.} and Esben Agerbo and B{\o}rglum, {Anders D.} and Hougaard, {David M.} and Merete Nordentoft and Thomas Werge and Mortensen, {Preben Bo} and Vilhj{\'a}lmsson, {Bjarni J.} and McGrath, {John J.}",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1038/s41467-023-36392-5",
language = "English",
volume = "14",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots

AU - Albiñana, Clara

AU - Zhu, Zhihong

AU - Borbye-Lorenzen, Nis

AU - Boelt, Sanne Grundvad

AU - Cohen, Arieh S.

AU - Skogstrand, Kristin

AU - Wray, Naomi R.

AU - Revez, Joana A.

AU - Privé, Florian

AU - Petersen, Liselotte V.

AU - Bulik, Cynthia M.

AU - Plana-Ripoll, Oleguer

AU - Musliner, Katherine L.

AU - Agerbo, Esben

AU - Børglum, Anders D.

AU - Hougaard, David M.

AU - Nordentoft, Merete

AU - Werge, Thomas

AU - Mortensen, Preben Bo

AU - Vilhjálmsson, Bjarni J.

AU - McGrath, John J.

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - The vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of which are in or close to the GC gene, with fine-mapping identifying 2 missense variants on chromosomes 12 and 17 (within SH2B3 and GSDMA, respectively). When adjusted for GC haplotypes, we find 15 independent loci distributed over 10 chromosomes. Mendelian randomization analyses identify a unidirectional effect of higher DBP concentration and (a) higher 25-hydroxyvitamin D concentration, and (b) a reduced risk of multiple sclerosis and rheumatoid arthritis. A phenome-wide association study confirms that higher DBP concentration is associated with a reduced risk of vitamin D deficiency. Our findings provide valuable insights into the influence of DBP on vitamin D status and a range of health outcomes.

AB - The vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of which are in or close to the GC gene, with fine-mapping identifying 2 missense variants on chromosomes 12 and 17 (within SH2B3 and GSDMA, respectively). When adjusted for GC haplotypes, we find 15 independent loci distributed over 10 chromosomes. Mendelian randomization analyses identify a unidirectional effect of higher DBP concentration and (a) higher 25-hydroxyvitamin D concentration, and (b) a reduced risk of multiple sclerosis and rheumatoid arthritis. A phenome-wide association study confirms that higher DBP concentration is associated with a reduced risk of vitamin D deficiency. Our findings provide valuable insights into the influence of DBP on vitamin D status and a range of health outcomes.

U2 - 10.1038/s41467-023-36392-5

DO - 10.1038/s41467-023-36392-5

M3 - Journal article

C2 - 36792583

AN - SCOPUS:85148115127

VL - 14

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 852

ER -

ID: 340844806