Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots
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Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots. / Albiñana, Clara; Zhu, Zhihong; Borbye-Lorenzen, Nis; Boelt, Sanne Grundvad; Cohen, Arieh S.; Skogstrand, Kristin; Wray, Naomi R.; Revez, Joana A.; Privé, Florian; Petersen, Liselotte V.; Bulik, Cynthia M.; Plana-Ripoll, Oleguer; Musliner, Katherine L.; Agerbo, Esben; Børglum, Anders D.; Hougaard, David M.; Nordentoft, Merete; Werge, Thomas; Mortensen, Preben Bo; Vilhjálmsson, Bjarni J.; McGrath, John J.
I: Nature Communications, Bind 14, 852, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots
AU - Albiñana, Clara
AU - Zhu, Zhihong
AU - Borbye-Lorenzen, Nis
AU - Boelt, Sanne Grundvad
AU - Cohen, Arieh S.
AU - Skogstrand, Kristin
AU - Wray, Naomi R.
AU - Revez, Joana A.
AU - Privé, Florian
AU - Petersen, Liselotte V.
AU - Bulik, Cynthia M.
AU - Plana-Ripoll, Oleguer
AU - Musliner, Katherine L.
AU - Agerbo, Esben
AU - Børglum, Anders D.
AU - Hougaard, David M.
AU - Nordentoft, Merete
AU - Werge, Thomas
AU - Mortensen, Preben Bo
AU - Vilhjálmsson, Bjarni J.
AU - McGrath, John J.
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - The vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of which are in or close to the GC gene, with fine-mapping identifying 2 missense variants on chromosomes 12 and 17 (within SH2B3 and GSDMA, respectively). When adjusted for GC haplotypes, we find 15 independent loci distributed over 10 chromosomes. Mendelian randomization analyses identify a unidirectional effect of higher DBP concentration and (a) higher 25-hydroxyvitamin D concentration, and (b) a reduced risk of multiple sclerosis and rheumatoid arthritis. A phenome-wide association study confirms that higher DBP concentration is associated with a reduced risk of vitamin D deficiency. Our findings provide valuable insights into the influence of DBP on vitamin D status and a range of health outcomes.
AB - The vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of which are in or close to the GC gene, with fine-mapping identifying 2 missense variants on chromosomes 12 and 17 (within SH2B3 and GSDMA, respectively). When adjusted for GC haplotypes, we find 15 independent loci distributed over 10 chromosomes. Mendelian randomization analyses identify a unidirectional effect of higher DBP concentration and (a) higher 25-hydroxyvitamin D concentration, and (b) a reduced risk of multiple sclerosis and rheumatoid arthritis. A phenome-wide association study confirms that higher DBP concentration is associated with a reduced risk of vitamin D deficiency. Our findings provide valuable insights into the influence of DBP on vitamin D status and a range of health outcomes.
U2 - 10.1038/s41467-023-36392-5
DO - 10.1038/s41467-023-36392-5
M3 - Journal article
C2 - 36792583
AN - SCOPUS:85148115127
VL - 14
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 852
ER -
ID: 340844806