Genetic biomarkers in melanoma of the ocular region: What the medical oncologist should know

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Genetic biomarkers in melanoma of the ocular region : What the medical oncologist should know. / Bol, Kalijn Fredrike; Donia, Marco; Heegaard, Steffen; Kiilgaard, Jens Folke; Svane, Inge Marie.

I: International Journal of Molecular Sciences , Bind 21, Nr. 15, 5231, 2020, s. 1-14.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Bol, KF, Donia, M, Heegaard, S, Kiilgaard, JF & Svane, IM 2020, 'Genetic biomarkers in melanoma of the ocular region: What the medical oncologist should know', International Journal of Molecular Sciences , bind 21, nr. 15, 5231, s. 1-14. https://doi.org/10.3390/ijms21155231

APA

Bol, K. F., Donia, M., Heegaard, S., Kiilgaard, J. F., & Svane, I. M. (2020). Genetic biomarkers in melanoma of the ocular region: What the medical oncologist should know. International Journal of Molecular Sciences , 21(15), 1-14. [5231]. https://doi.org/10.3390/ijms21155231

Vancouver

Bol KF, Donia M, Heegaard S, Kiilgaard JF, Svane IM. Genetic biomarkers in melanoma of the ocular region: What the medical oncologist should know. International Journal of Molecular Sciences . 2020;21(15):1-14. 5231. https://doi.org/10.3390/ijms21155231

Author

Bol, Kalijn Fredrike ; Donia, Marco ; Heegaard, Steffen ; Kiilgaard, Jens Folke ; Svane, Inge Marie. / Genetic biomarkers in melanoma of the ocular region : What the medical oncologist should know. I: International Journal of Molecular Sciences . 2020 ; Bind 21, Nr. 15. s. 1-14.

Bibtex

@article{3a9c25bba0b748fcbd6ca2686af6d5c9,
title = "Genetic biomarkers in melanoma of the ocular region: What the medical oncologist should know",
abstract = "Melanoma of the ocular region (ocular melanoma) comprises about 5% of all patients with melanoma and covers posterior uveal melanoma, iris melanoma, and conjunctival melanoma. The risk of metastasis is much higher in patients with ocular melanoma compared to a primary melanoma of the skin. The subtypes of ocular melanoma have distinct genetic features, which should be taken into consideration when making clinical decisions. Most relevant for current practice is the absence of BRAF mutations in posterior uveal melanoma, although present in some iris melanomas and conjunctival melanomas. In this review, we discuss the genetic biomarkers of the subtypes of ocular melanoma and their impacts on the clinical care of these patients.",
keywords = "BRAF mutation, Conjunctival melanoma, Genetic biomarkers, Iris melanoma, Ocular melanoma, Posterior uveal melanoma",
author = "Bol, {Kalijn Fredrike} and Marco Donia and Steffen Heegaard and Kiilgaard, {Jens Folke} and Svane, {Inge Marie}",
year = "2020",
doi = "10.3390/ijms21155231",
language = "English",
volume = "21",
pages = "1--14",
journal = "International Journal of Molecular Sciences (Online)",
issn = "1661-6596",
publisher = "MDPI AG",
number = "15",

}

RIS

TY - JOUR

T1 - Genetic biomarkers in melanoma of the ocular region

T2 - What the medical oncologist should know

AU - Bol, Kalijn Fredrike

AU - Donia, Marco

AU - Heegaard, Steffen

AU - Kiilgaard, Jens Folke

AU - Svane, Inge Marie

PY - 2020

Y1 - 2020

N2 - Melanoma of the ocular region (ocular melanoma) comprises about 5% of all patients with melanoma and covers posterior uveal melanoma, iris melanoma, and conjunctival melanoma. The risk of metastasis is much higher in patients with ocular melanoma compared to a primary melanoma of the skin. The subtypes of ocular melanoma have distinct genetic features, which should be taken into consideration when making clinical decisions. Most relevant for current practice is the absence of BRAF mutations in posterior uveal melanoma, although present in some iris melanomas and conjunctival melanomas. In this review, we discuss the genetic biomarkers of the subtypes of ocular melanoma and their impacts on the clinical care of these patients.

AB - Melanoma of the ocular region (ocular melanoma) comprises about 5% of all patients with melanoma and covers posterior uveal melanoma, iris melanoma, and conjunctival melanoma. The risk of metastasis is much higher in patients with ocular melanoma compared to a primary melanoma of the skin. The subtypes of ocular melanoma have distinct genetic features, which should be taken into consideration when making clinical decisions. Most relevant for current practice is the absence of BRAF mutations in posterior uveal melanoma, although present in some iris melanomas and conjunctival melanomas. In this review, we discuss the genetic biomarkers of the subtypes of ocular melanoma and their impacts on the clinical care of these patients.

KW - BRAF mutation

KW - Conjunctival melanoma

KW - Genetic biomarkers

KW - Iris melanoma

KW - Ocular melanoma

KW - Posterior uveal melanoma

U2 - 10.3390/ijms21155231

DO - 10.3390/ijms21155231

M3 - Review

C2 - 32718045

AN - SCOPUS:85088812713

VL - 21

SP - 1

EP - 14

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 15

M1 - 5231

ER -

ID: 256216961