Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders

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Standard

Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders. / Ersland, Kari M; Christoforou, Andrea; Stansberg, Christine; Espeseth, Thomas; Mattheisen, Manuel; Mattingsdal, Morten; Hardarson, Gudmundur A; Hansen, Thomas; Fernandes, Carla P D; Giddaluru, Sudheer; Breuer, René; Strohmaier, Jana; Djurovic, Srdjan; Nöthen, Markus M; Rietschel, Marcella; Lundervold, Astri J; Werge, Thomas; Cichon, Sven; Andreassen, Ole A; Reinvang, Ivar; Steen, Vidar M; Le Hellard, Stephanie.

I: P L o S One, Bind 7, Nr. 2, 2012, s. e31687.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ersland, KM, Christoforou, A, Stansberg, C, Espeseth, T, Mattheisen, M, Mattingsdal, M, Hardarson, GA, Hansen, T, Fernandes, CPD, Giddaluru, S, Breuer, R, Strohmaier, J, Djurovic, S, Nöthen, MM, Rietschel, M, Lundervold, AJ, Werge, T, Cichon, S, Andreassen, OA, Reinvang, I, Steen, VM & Le Hellard, S 2012, 'Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders', P L o S One, bind 7, nr. 2, s. e31687. https://doi.org/10.1371/journal.pone.0031687

APA

Ersland, K. M., Christoforou, A., Stansberg, C., Espeseth, T., Mattheisen, M., Mattingsdal, M., Hardarson, G. A., Hansen, T., Fernandes, C. P. D., Giddaluru, S., Breuer, R., Strohmaier, J., Djurovic, S., Nöthen, M. M., Rietschel, M., Lundervold, A. J., Werge, T., Cichon, S., Andreassen, O. A., ... Le Hellard, S. (2012). Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders. P L o S One, 7(2), e31687. https://doi.org/10.1371/journal.pone.0031687

Vancouver

Ersland KM, Christoforou A, Stansberg C, Espeseth T, Mattheisen M, Mattingsdal M o.a. Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders. P L o S One. 2012;7(2):e31687. https://doi.org/10.1371/journal.pone.0031687

Author

Ersland, Kari M ; Christoforou, Andrea ; Stansberg, Christine ; Espeseth, Thomas ; Mattheisen, Manuel ; Mattingsdal, Morten ; Hardarson, Gudmundur A ; Hansen, Thomas ; Fernandes, Carla P D ; Giddaluru, Sudheer ; Breuer, René ; Strohmaier, Jana ; Djurovic, Srdjan ; Nöthen, Markus M ; Rietschel, Marcella ; Lundervold, Astri J ; Werge, Thomas ; Cichon, Sven ; Andreassen, Ole A ; Reinvang, Ivar ; Steen, Vidar M ; Le Hellard, Stephanie. / Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders. I: P L o S One. 2012 ; Bind 7, Nr. 2. s. e31687.

Bibtex

@article{75cafbd301c043cd8f462414ca861381,
title = "Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders",
abstract = "Despite its estimated high heritability, the genetic architecture leading to differences in cognitive performance remains poorly understood. Different cortical regions play important roles in normal cognitive functioning and impairment. Recently, we reported on sets of regionally enriched genes in three different cortical areas (frontomedial, temporal and occipital cortices) of the adult rat brain. It has been suggested that genes preferentially, or specifically, expressed in one region or organ reflect functional specialisation. Employing a gene-based approach to the analysis, we used the regionally enriched cortical genes to mine a genome-wide association study (GWAS) of the Norwegian Cognitive NeuroGenetics (NCNG) sample of healthy adults for association to nine psychometric tests measures. In addition, we explored GWAS data sets for the serious psychiatric disorders schizophrenia (SCZ) (n¿=¿3 samples) and bipolar affective disorder (BP) (n¿=¿3 samples), to which cognitive impairment is linked.",
author = "Ersland, {Kari M} and Andrea Christoforou and Christine Stansberg and Thomas Espeseth and Manuel Mattheisen and Morten Mattingsdal and Hardarson, {Gudmundur A} and Thomas Hansen and Fernandes, {Carla P D} and Sudheer Giddaluru and Ren{\'e} Breuer and Jana Strohmaier and Srdjan Djurovic and N{\"o}then, {Markus M} and Marcella Rietschel and Lundervold, {Astri J} and Thomas Werge and Sven Cichon and Andreassen, {Ole A} and Ivar Reinvang and Steen, {Vidar M} and {Le Hellard}, Stephanie",
year = "2012",
doi = "10.1371/journal.pone.0031687",
language = "English",
volume = "7",
pages = "e31687",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders

AU - Ersland, Kari M

AU - Christoforou, Andrea

AU - Stansberg, Christine

AU - Espeseth, Thomas

AU - Mattheisen, Manuel

AU - Mattingsdal, Morten

AU - Hardarson, Gudmundur A

AU - Hansen, Thomas

AU - Fernandes, Carla P D

AU - Giddaluru, Sudheer

AU - Breuer, René

AU - Strohmaier, Jana

AU - Djurovic, Srdjan

AU - Nöthen, Markus M

AU - Rietschel, Marcella

AU - Lundervold, Astri J

AU - Werge, Thomas

AU - Cichon, Sven

AU - Andreassen, Ole A

AU - Reinvang, Ivar

AU - Steen, Vidar M

AU - Le Hellard, Stephanie

PY - 2012

Y1 - 2012

N2 - Despite its estimated high heritability, the genetic architecture leading to differences in cognitive performance remains poorly understood. Different cortical regions play important roles in normal cognitive functioning and impairment. Recently, we reported on sets of regionally enriched genes in three different cortical areas (frontomedial, temporal and occipital cortices) of the adult rat brain. It has been suggested that genes preferentially, or specifically, expressed in one region or organ reflect functional specialisation. Employing a gene-based approach to the analysis, we used the regionally enriched cortical genes to mine a genome-wide association study (GWAS) of the Norwegian Cognitive NeuroGenetics (NCNG) sample of healthy adults for association to nine psychometric tests measures. In addition, we explored GWAS data sets for the serious psychiatric disorders schizophrenia (SCZ) (n¿=¿3 samples) and bipolar affective disorder (BP) (n¿=¿3 samples), to which cognitive impairment is linked.

AB - Despite its estimated high heritability, the genetic architecture leading to differences in cognitive performance remains poorly understood. Different cortical regions play important roles in normal cognitive functioning and impairment. Recently, we reported on sets of regionally enriched genes in three different cortical areas (frontomedial, temporal and occipital cortices) of the adult rat brain. It has been suggested that genes preferentially, or specifically, expressed in one region or organ reflect functional specialisation. Employing a gene-based approach to the analysis, we used the regionally enriched cortical genes to mine a genome-wide association study (GWAS) of the Norwegian Cognitive NeuroGenetics (NCNG) sample of healthy adults for association to nine psychometric tests measures. In addition, we explored GWAS data sets for the serious psychiatric disorders schizophrenia (SCZ) (n¿=¿3 samples) and bipolar affective disorder (BP) (n¿=¿3 samples), to which cognitive impairment is linked.

U2 - 10.1371/journal.pone.0031687

DO - 10.1371/journal.pone.0031687

M3 - Journal article

VL - 7

SP - e31687

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 2

ER -

ID: 40205013