TY - JOUR

T1 - Gallstone Risk in Adult Patients with Atopic Dermatitis and Psoriasis

T2 - Possible Effect of Overweight and Obesity

AU - Egeberg, Alexander

AU - Andersen, Yuki M.F.

AU - Gislason, Gunnar H.

AU - Skov, Lone

AU - Thyssen, Jacob P.

PY - 2017

Y1 - 2017

N2 - Adult atopic dermatitis (AD) is associated with overweight, obesity and cardiovascular diseases (CVD) in Americans, similarly to psoriasis, but no increased risk of CVD has been shown in European patients with AD. This study investigated the prevalence and risk of gallstones in adults with AD and in those with psoriasis as a proxy for obesity using nationwide data for all Danish citizens ≥ 30 years of age. Outcome was a diagnosis of gallstones. Odds ratios (ORs) were calculated by logistic regression (cross-sectional study) and hazard ratios (HRs) were estimated by Cox regression (cohort study). The study comprised 6,742 patients with AD, 53,810 patients with psoriasis, and 3,534,164 general population subjects. The prevalence of gallstones was 3.8%, 3.5% and 5.0% in the general population, AD and psoriasis patients, respectively. Adjusted ORs were 0.81 (0.71–0.92) for AD and 1.18 (1.14–1.23) for psoriasis. During follow-up, adjusted HRs were 0.72 (0.56–0.90) for AD and 1.10 (1.02–1.18) for psoriasis. The findings highlight important differences in obesity and lifestyle factors among patients with AD and those with psoriasis.

AB - Adult atopic dermatitis (AD) is associated with overweight, obesity and cardiovascular diseases (CVD) in Americans, similarly to psoriasis, but no increased risk of CVD has been shown in European patients with AD. This study investigated the prevalence and risk of gallstones in adults with AD and in those with psoriasis as a proxy for obesity using nationwide data for all Danish citizens ≥ 30 years of age. Outcome was a diagnosis of gallstones. Odds ratios (ORs) were calculated by logistic regression (cross-sectional study) and hazard ratios (HRs) were estimated by Cox regression (cohort study). The study comprised 6,742 patients with AD, 53,810 patients with psoriasis, and 3,534,164 general population subjects. The prevalence of gallstones was 3.8%, 3.5% and 5.0% in the general population, AD and psoriasis patients, respectively. Adjusted ORs were 0.81 (0.71–0.92) for AD and 1.18 (1.14–1.23) for psoriasis. During follow-up, adjusted HRs were 0.72 (0.56–0.90) for AD and 1.10 (1.02–1.18) for psoriasis. The findings highlight important differences in obesity and lifestyle factors among patients with AD and those with psoriasis.

KW - Atopic dermatitis

KW - BMI

KW - Gallstones

KW - Obesity

KW - Psoriasis

UR - http://www.scopus.com/inward/record.url?scp=85014930435&partnerID=8YFLogxK

U2 - 10.2340/00015555-2622

DO - 10.2340/00015555-2622

M3 - Journal article

C2 - 28119993

AN - SCOPUS:85014930435

VL - 97

SP - 627

EP - 631

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

IS - 5

ER -