Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

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Standard

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. / Wakhloo, Debia; Scharkowski, Franziska; Curto, Yasmina; Butt, Umer Javed; Bansal, Vikas; Steixner-Kumar, Agnes A.; Wuestefeld, Liane; Rajput, Ashish; Arinrad, Sahab; Zillmann, Matthias R.; Seelbach, Anna; Hassouna, Imam; Schneider, Katharina; Ibrahim, Abdul Qadir; Werner, Hauke B.; Martens, Henrik; Miskowiak, Kamilla; Wojcik, Sonja M.; Bonn, Stefan; Nacher, Juan; Nave, Klaus-Armin; Ehrenreich, Hannelore.

I: Nature Communications, Bind 11, Nr. 1, 1313, 09.03.2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wakhloo, D, Scharkowski, F, Curto, Y, Butt, UJ, Bansal, V, Steixner-Kumar, AA, Wuestefeld, L, Rajput, A, Arinrad, S, Zillmann, MR, Seelbach, A, Hassouna, I, Schneider, K, Ibrahim, AQ, Werner, HB, Martens, H, Miskowiak, K, Wojcik, SM, Bonn, S, Nacher, J, Nave, K-A & Ehrenreich, H 2020, 'Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin', Nature Communications, bind 11, nr. 1, 1313. https://doi.org/10.1038/s41467-020-15041-1

APA

Wakhloo, D., Scharkowski, F., Curto, Y., Butt, U. J., Bansal, V., Steixner-Kumar, A. A., Wuestefeld, L., Rajput, A., Arinrad, S., Zillmann, M. R., Seelbach, A., Hassouna, I., Schneider, K., Ibrahim, A. Q., Werner, H. B., Martens, H., Miskowiak, K., Wojcik, S. M., Bonn, S., ... Ehrenreich, H. (2020). Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. Nature Communications, 11(1), [1313]. https://doi.org/10.1038/s41467-020-15041-1

Vancouver

Wakhloo D, Scharkowski F, Curto Y, Butt UJ, Bansal V, Steixner-Kumar AA o.a. Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. Nature Communications. 2020 mar. 9;11(1). 1313. https://doi.org/10.1038/s41467-020-15041-1

Author

Wakhloo, Debia ; Scharkowski, Franziska ; Curto, Yasmina ; Butt, Umer Javed ; Bansal, Vikas ; Steixner-Kumar, Agnes A. ; Wuestefeld, Liane ; Rajput, Ashish ; Arinrad, Sahab ; Zillmann, Matthias R. ; Seelbach, Anna ; Hassouna, Imam ; Schneider, Katharina ; Ibrahim, Abdul Qadir ; Werner, Hauke B. ; Martens, Henrik ; Miskowiak, Kamilla ; Wojcik, Sonja M. ; Bonn, Stefan ; Nacher, Juan ; Nave, Klaus-Armin ; Ehrenreich, Hannelore. / Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. I: Nature Communications. 2020 ; Bind 11, Nr. 1.

Bibtex

@article{b46d82ba2ae047f087b5c3db95fe9638,

title = "Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin",

abstract = "Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed in mammalian brain. In clinical settings, recombinant EPO treatment has revealed a remarkable improvement of cognition, but underlying mechanisms have remained obscure. Here, we show with a novel line of reporter mice that cognitive challenge induces local/endogenous hypoxia in hippocampal pyramidal neurons, hence enhancing expression of EPO and EPO receptor (EPOR). High-dose EPO administration, amplifying auto/paracrine EPO/EPOR signaling, prompts the emergence of new CA1 neurons and enhanced dendritic spine densities. Single-cell sequencing reveals rapid increase in newly differentiating neurons. Importantly, improved performance on complex running wheels after EPO is imitated by exposure to mild exogenous/inspiratory hypoxia. All these effects depend on neuronal expression of the Epor gene. This suggests a model of neuroplasticity in form of a fundamental regulatory circle, in which neuronal networks-challenged by cognitive tasks-drift into transient hypoxia, thereby triggering neuronal EPO/EPOR expression.",

keywords = "RECOMBINANT-HUMAN-ERYTHROPOIETIN, HEMATOPOIETIC PROGENITOR CELLS, ADULT NEUROGENESIS, EXPRESSION, MEMORY, VARIANTS, IDENTITY, NEURONS, MICE",

author = "Debia Wakhloo and Franziska Scharkowski and Yasmina Curto and Butt, {Umer Javed} and Vikas Bansal and Steixner-Kumar, {Agnes A.} and Liane Wuestefeld and Ashish Rajput and Sahab Arinrad and Zillmann, {Matthias R.} and Anna Seelbach and Imam Hassouna and Katharina Schneider and Ibrahim, {Abdul Qadir} and Werner, {Hauke B.} and Henrik Martens and Kamilla Miskowiak and Wojcik, {Sonja M.} and Stefan Bonn and Juan Nacher and Klaus-Armin Nave and Hannelore Ehrenreich",

year = "2020",

month = mar,

day = "9",

doi = "10.1038/s41467-020-15041-1",

language = "English",

volume = "11",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "nature publishing group",

number = "1",

}

RIS

TY - JOUR

T1 - Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

AU - Wakhloo, Debia

AU - Scharkowski, Franziska

AU - Curto, Yasmina

AU - Butt, Umer Javed

AU - Bansal, Vikas

AU - Steixner-Kumar, Agnes A.

AU - Wuestefeld, Liane

AU - Rajput, Ashish

AU - Arinrad, Sahab

AU - Zillmann, Matthias R.

AU - Seelbach, Anna

AU - Hassouna, Imam

AU - Schneider, Katharina

AU - Ibrahim, Abdul Qadir

AU - Werner, Hauke B.

AU - Martens, Henrik

AU - Miskowiak, Kamilla

AU - Wojcik, Sonja M.

AU - Bonn, Stefan

AU - Nacher, Juan

AU - Nave, Klaus-Armin

AU - Ehrenreich, Hannelore

PY - 2020/3/9

Y1 - 2020/3/9

N2 - Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed in mammalian brain. In clinical settings, recombinant EPO treatment has revealed a remarkable improvement of cognition, but underlying mechanisms have remained obscure. Here, we show with a novel line of reporter mice that cognitive challenge induces local/endogenous hypoxia in hippocampal pyramidal neurons, hence enhancing expression of EPO and EPO receptor (EPOR). High-dose EPO administration, amplifying auto/paracrine EPO/EPOR signaling, prompts the emergence of new CA1 neurons and enhanced dendritic spine densities. Single-cell sequencing reveals rapid increase in newly differentiating neurons. Importantly, improved performance on complex running wheels after EPO is imitated by exposure to mild exogenous/inspiratory hypoxia. All these effects depend on neuronal expression of the Epor gene. This suggests a model of neuroplasticity in form of a fundamental regulatory circle, in which neuronal networks-challenged by cognitive tasks-drift into transient hypoxia, thereby triggering neuronal EPO/EPOR expression.

AB - Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed in mammalian brain. In clinical settings, recombinant EPO treatment has revealed a remarkable improvement of cognition, but underlying mechanisms have remained obscure. Here, we show with a novel line of reporter mice that cognitive challenge induces local/endogenous hypoxia in hippocampal pyramidal neurons, hence enhancing expression of EPO and EPO receptor (EPOR). High-dose EPO administration, amplifying auto/paracrine EPO/EPOR signaling, prompts the emergence of new CA1 neurons and enhanced dendritic spine densities. Single-cell sequencing reveals rapid increase in newly differentiating neurons. Importantly, improved performance on complex running wheels after EPO is imitated by exposure to mild exogenous/inspiratory hypoxia. All these effects depend on neuronal expression of the Epor gene. This suggests a model of neuroplasticity in form of a fundamental regulatory circle, in which neuronal networks-challenged by cognitive tasks-drift into transient hypoxia, thereby triggering neuronal EPO/EPOR expression.

KW - RECOMBINANT-HUMAN-ERYTHROPOIETIN

KW - HEMATOPOIETIC PROGENITOR CELLS

KW - ADULT NEUROGENESIS

KW - EXPRESSION

KW - MEMORY

KW - VARIANTS

KW - IDENTITY

KW - NEURONS

KW - MICE

U2 - 10.1038/s41467-020-15041-1

DO - 10.1038/s41467-020-15041-1

M3 - Journal article

C2 - 32152318

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 1313

ER -

ID: 256074910