Functional genomic screens with death rate analyses reveal mechanisms of drug action
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Originalsprog | Engelsk |
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Tidsskrift | Nature Chemical Biology |
ISSN | 1552-4450 |
DOI | |
Status | E-pub ahead of print - 2024 |
Bibliografisk note
Funding Information:
We thank current and past members of the UMass Chan Medical School DSB community for their helpful comments and critiques during the design and execution of this study. Additionally, we thank T. Leete for assistance with training in an early stage of this project; C. Navarro for thoughtful comments and editing of this paper; C. Baer and the UMass Chan SCOPE Core for assistance with some microscopy experiments; A. Mitchell for providing an H2B-mCherry plasmid; T. Fazzio for providing the pX330 plasmid; T. Fortier, E. Baehrecke and the UMass Chan Electron Microscopy Core for assistance with transmission electron microscopy experiments; and M. Green and D. Kim for providing access to some of the cell lines used in this study. M.S.I. is supported by the Novo Nordisk Foundation Center for Basic Metabolic Research, an independent research center based at the University of Copenhagen, and partially funded by an unconditional donation from the Novo Nordisk Foundation (grant number NNF18CC0034900). This work was supported by grants from the National Institutes of Health/National Institute of General Medical Sciences (R01GM127559 to M.J.L.), the National Cancer Institute (F31CA268847 to M.E.H.), the JKTG Foundation (to M.J.L.) and the American Cancer Society (RSG-17-011-01 to M.J.L.).
Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.
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