Frequency of glucocorticoid resistance and dependency in Crohn's disease
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Frequency of glucocorticoid resistance and dependency in Crohn's disease. / Munkholm, P; Langholz, E; Davidsen, M; Binder, V.
I: Gut, Bind 35, Nr. 3, 03.1994, s. 360-2.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Frequency of glucocorticoid resistance and dependency in Crohn's disease
AU - Munkholm, P
AU - Langholz, E
AU - Davidsen, M
AU - Binder, V
PY - 1994/3
Y1 - 1994/3
N2 - The outcome of the first steroid treatment course was prospectively studied in a regional cohort of 196 patients with Crohn's disease diagnosed 1979-1987. The immediate outcome after 30 days, and the prolonged outcome 30 days after treatment had stopped, are described. In all 109 patients treatment was analysed. Complete remission was obtained in 48%, partial remission in 32%, and no response in 20% within 30 days of treatment. Among primary responders (complete and partial remission), 55% remained in prolonged response after treatment had finished, while 45% relapsed or could not be withdrawn from treatment within one year. Localisation of disease, age, sex or clinical symptoms did not significantly correlate with outcome, which can be summarised as prolonged steroid response in 44%, steroid dependency in 36%, and steroid resistant in 20% of the patients.
AB - The outcome of the first steroid treatment course was prospectively studied in a regional cohort of 196 patients with Crohn's disease diagnosed 1979-1987. The immediate outcome after 30 days, and the prolonged outcome 30 days after treatment had stopped, are described. In all 109 patients treatment was analysed. Complete remission was obtained in 48%, partial remission in 32%, and no response in 20% within 30 days of treatment. Among primary responders (complete and partial remission), 55% remained in prolonged response after treatment had finished, while 45% relapsed or could not be withdrawn from treatment within one year. Localisation of disease, age, sex or clinical symptoms did not significantly correlate with outcome, which can be summarised as prolonged steroid response in 44%, steroid dependency in 36%, and steroid resistant in 20% of the patients.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Child
KW - Cohort Studies
KW - Crohn Disease/drug therapy
KW - Drug Resistance
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Prednisolone/therapeutic use
KW - Prospective Studies
KW - Time Factors
KW - Treatment Outcome
U2 - 10.1136/gut.35.3.360
DO - 10.1136/gut.35.3.360
M3 - Journal article
C2 - 8150347
VL - 35
SP - 360
EP - 362
JO - Gut
JF - Gut
SN - 0017-5749
IS - 3
ER -
ID: 219530986