Frequency of atopy in the Arctic in 1987 and 1998
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Frequency of atopy in the Arctic in 1987 and 1998. / Krause, Tyra; Koch, Anders; Friborg, Jeppe; Poulsen, Lars K.; Kristensen, Bjarne; Melbye, Mads.
I: Lancet, Bind 360, Nr. 9334, 31.08.2002, s. 691-2.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Frequency of atopy in the Arctic in 1987 and 1998
AU - Krause, Tyra
AU - Koch, Anders
AU - Friborg, Jeppe
AU - Poulsen, Lars K.
AU - Kristensen, Bjarne
AU - Melbye, Mads
PY - 2002/8/31
Y1 - 2002/8/31
N2 - Few studies have measured the frequency of atopy with objective measures, and most of these studies have been done in industrialised countries. We analysed serum samples from 859 15-80-year-old Greenlanders who had participated in population-based screening campaigns in 1987 and in 1998. We defined atopy as a positive result in an assay that tests for specific IgE against the eight most common inhalant allergens in one pool (grass, birch, mugwort, dog, cat, horse, Cladosporum herbarum, house dust mite). The frequency of atopy doubled between 1987 (39 [10%] of 392) and 1998 (87 [19%] of 467; risk ratio 1.88 [95% CI 1.31-2.68]). This increase was largest in 15-19-year olds, but also occurred in older people, suggesting that the risk factors responsible for the increase in atopy do not operate only in childhood.
AB - Few studies have measured the frequency of atopy with objective measures, and most of these studies have been done in industrialised countries. We analysed serum samples from 859 15-80-year-old Greenlanders who had participated in population-based screening campaigns in 1987 and in 1998. We defined atopy as a positive result in an assay that tests for specific IgE against the eight most common inhalant allergens in one pool (grass, birch, mugwort, dog, cat, horse, Cladosporum herbarum, house dust mite). The frequency of atopy doubled between 1987 (39 [10%] of 392) and 1998 (87 [19%] of 467; risk ratio 1.88 [95% CI 1.31-2.68]). This increase was largest in 15-19-year olds, but also occurred in older people, suggesting that the risk factors responsible for the increase in atopy do not operate only in childhood.
KW - Adolescent
KW - Adult
KW - Age Distribution
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Allergens
KW - Dermatitis, Atopic
KW - Female
KW - Greenland
KW - Humans
KW - Immunoglobulin E
KW - Male
KW - Mass Screening
KW - Middle Aged
KW - Risk Factors
M3 - Journal article
C2 - 12241878
VL - 360
SP - 691
EP - 692
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 9334
ER -
ID: 50845297