Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
FFA1 (GPR40) is a new target for treatment of type 2 diabetes. We recently identified the potent FFA1 agonist TUG-469 (5). Inspired by the structurally related TAK-875, we explored the effects of a mesylpropoxy appendage on 5. The appendage significantly lowers lipophilicity and improves metabolic stability while preserving potency, resulting in discovery of the potent FFA1 agonist 13.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Medicinal Chemistry |
Vol/bind | 55 |
Udgave nummer | 14 |
Sider (fra-til) | 6624-6628 |
Antal sider | 5 |
ISSN | 0022-2623 |
DOI | |
Status | Udgivet - 2012 |
Eksternt udgivet | Ja |
ID: 189162178