Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy: a DANAMI-3-PRIMULTI Sub-study
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Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy : a DANAMI-3-PRIMULTI Sub-study. / Sabbah, Muhammad; Nepper-Christensen, Lars; Lønborg, Jacob; Helqvist, Steffen; Køber, Lars; Høfsten, Dan Eik; Ahtarovski, Kiril Aleksov; Göransson, Christoffer; Kyhl, Kasper; Schoos, Mikkel Malby; Vejlstrup, Niels; Kelbæk, Henning; Engstrøm, Thomas.
I: EuroIntervention, Bind 16, 2020, s. 584-590.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Fractional Flow Reserve Guided PCI in Patients With and Without Left Ventricular Hypertrophy
T2 - a DANAMI-3-PRIMULTI Sub-study
AU - Sabbah, Muhammad
AU - Nepper-Christensen, Lars
AU - Lønborg, Jacob
AU - Helqvist, Steffen
AU - Køber, Lars
AU - Høfsten, Dan Eik
AU - Ahtarovski, Kiril Aleksov
AU - Göransson, Christoffer
AU - Kyhl, Kasper
AU - Schoos, Mikkel Malby
AU - Vejlstrup, Niels
AU - Kelbæk, Henning
AU - Engstrøm, Thomas
PY - 2020
Y1 - 2020
N2 - AIMS: To investigate the correlation between fractional flow reserve (FFR) and diameter stenosis in patients with STEMI with and without left ventricular hypertrophy (LVH), and the influence of LVH on complete FFR-guided revascularization versus culprit only, in terms of risk of clinical outcome.METHODS AND RESULTS: In this DANAMI-3-PRIMULTI sub-study, 279 patients with STEMI had cardiac magnetic resonance (CMR) for assessment of left-ventricular-mass-index. Ninety-six patients had FFR evaluation of a non-culprit lesion. Diameter stenosis of the non-culprit lesion was determined with 2-dimensional quantitative-coronary-analysis. The diameter stenosis (56.9% vs. 54.3%, p=0.38) and FFR value (0.83 vs. 0.85, p=0.34) were significantly correlated in both groups (Spearmans ρ=-0.40 and -0.41 without LVH and with LVH, respectively; p<0.001) but was not different between patients without and with LVH (p for interaction =0.87). FFR-guided complete revascularization was associated with reduced risk of death, myocardial infarction or ischemia-driven revascularization for both patients without LVH (HR 0.42, 95%CI 0.20-0.85) and for patients with LVH (HR 0.50, 95%CI 0.17-0.47), with no interaction between the FFR-guided complete revascularization and LVH (p for interaction =0.82).CONCLUSIONS: LVH did not interact with the correlation between diameter stenosis and FFR and did not modify the impact of complete revascularization on the occurrence of subsequent clinical events.
AB - AIMS: To investigate the correlation between fractional flow reserve (FFR) and diameter stenosis in patients with STEMI with and without left ventricular hypertrophy (LVH), and the influence of LVH on complete FFR-guided revascularization versus culprit only, in terms of risk of clinical outcome.METHODS AND RESULTS: In this DANAMI-3-PRIMULTI sub-study, 279 patients with STEMI had cardiac magnetic resonance (CMR) for assessment of left-ventricular-mass-index. Ninety-six patients had FFR evaluation of a non-culprit lesion. Diameter stenosis of the non-culprit lesion was determined with 2-dimensional quantitative-coronary-analysis. The diameter stenosis (56.9% vs. 54.3%, p=0.38) and FFR value (0.83 vs. 0.85, p=0.34) were significantly correlated in both groups (Spearmans ρ=-0.40 and -0.41 without LVH and with LVH, respectively; p<0.001) but was not different between patients without and with LVH (p for interaction =0.87). FFR-guided complete revascularization was associated with reduced risk of death, myocardial infarction or ischemia-driven revascularization for both patients without LVH (HR 0.42, 95%CI 0.20-0.85) and for patients with LVH (HR 0.50, 95%CI 0.17-0.47), with no interaction between the FFR-guided complete revascularization and LVH (p for interaction =0.82).CONCLUSIONS: LVH did not interact with the correlation between diameter stenosis and FFR and did not modify the impact of complete revascularization on the occurrence of subsequent clinical events.
U2 - 10.4244/EIJ-D-19-00577
DO - 10.4244/EIJ-D-19-00577
M3 - Journal article
C2 - 31746761
VL - 16
SP - 584
EP - 590
JO - EuroIntervention
JF - EuroIntervention
SN - 1774-024X
ER -
ID: 238483166