Feasibility of breathing-adapted PET/CT imaging for radiation therapy of Hodgkin lymphoma
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Feasibility of breathing-adapted PET/CT imaging for radiation therapy of Hodgkin lymphoma. / Aznar, M C; Andersen, Flemming; Berthelsen, A K; Josipovic, M; Klausen, T L; Jakobsen, Annika Loft; Olsen, M; Petersen, P M; Specht, L.
I: Cancer Imaging, Bind 11, 2011, s. S117.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Feasibility of breathing-adapted PET/CT imaging for radiation therapy of Hodgkin lymphoma
AU - Aznar, M C
AU - Andersen, Flemming
AU - Berthelsen, A K
AU - Josipovic, M
AU - Klausen, T L
AU - Jakobsen, Annika Loft
AU - Olsen, M
AU - Petersen, P M
AU - Specht, L
PY - 2011
Y1 - 2011
N2 - Aim: Respiration can induce artifacts in positron emission tomography (PET)/computed tomography (CT) images leading to uncertainties in tumour volume, location and uptake quantification. Respiratory gating for PET images is now established but is not directly translatable to a radiotherapy setup. We investigate the feasibility of introducing a deep inspiration breath hold (DIBH) strategy in PET/CT imaging of Hodgkin lymphoma patients and its impact on image quantification parameters. Methods: Three patients with suspicion of large mediastinal tumour burden were selected for this study and imaged in a Siemens Biograph 40 PET/CT before chemotherapy after injection of 400 MBq of FDG. The DIBH level reproducibility was ensured by visual coaching. Clinical free breathing (FB) scan was followed by a DIBH scan, acquired as 3 breathholds of 20¿s each (1 PET field of view). Images were reconstructed with a TrueX algorithm (point spread function, 3 iterations 21 subsets, 2-mm full width half maximum Gaussian filtering). Active areas of uptake were delineated using automatic thresholds of 40% and 50% of maximum standardized uptake value (SUVmax). Results: SUVmax is on average 20% higher in DIBH than in FB images (range 18-22%) due to the absence of breathing motion. In contrast, the volumes at 40% and 50% of SUVmax are smaller at DIBH than at FB (by up to 80 cm(3)). Conclusion: DIBH is feasible and well tolerated in this patient group, and results in considerable changes in apparent uptake in PET/CT images. These results suggest that advanced therapies (such as SUV-based dose painting) will likely require breathing-adapted PET images and that the relevant SUV thresholds are yet to be investigated.
AB - Aim: Respiration can induce artifacts in positron emission tomography (PET)/computed tomography (CT) images leading to uncertainties in tumour volume, location and uptake quantification. Respiratory gating for PET images is now established but is not directly translatable to a radiotherapy setup. We investigate the feasibility of introducing a deep inspiration breath hold (DIBH) strategy in PET/CT imaging of Hodgkin lymphoma patients and its impact on image quantification parameters. Methods: Three patients with suspicion of large mediastinal tumour burden were selected for this study and imaged in a Siemens Biograph 40 PET/CT before chemotherapy after injection of 400 MBq of FDG. The DIBH level reproducibility was ensured by visual coaching. Clinical free breathing (FB) scan was followed by a DIBH scan, acquired as 3 breathholds of 20¿s each (1 PET field of view). Images were reconstructed with a TrueX algorithm (point spread function, 3 iterations 21 subsets, 2-mm full width half maximum Gaussian filtering). Active areas of uptake were delineated using automatic thresholds of 40% and 50% of maximum standardized uptake value (SUVmax). Results: SUVmax is on average 20% higher in DIBH than in FB images (range 18-22%) due to the absence of breathing motion. In contrast, the volumes at 40% and 50% of SUVmax are smaller at DIBH than at FB (by up to 80 cm(3)). Conclusion: DIBH is feasible and well tolerated in this patient group, and results in considerable changes in apparent uptake in PET/CT images. These results suggest that advanced therapies (such as SUV-based dose painting) will likely require breathing-adapted PET images and that the relevant SUV thresholds are yet to be investigated.
U2 - http://dx.doi.org/10.1102/1470-7330.2011.9063
DO - http://dx.doi.org/10.1102/1470-7330.2011.9063
M3 - Journal article
VL - 11
SP - S117
JO - Cancer Imaging
JF - Cancer Imaging
SN - 1740-5025
ER -
ID: 40196119