Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding
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Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding. / Frøkjær, Vibe Gedsø; Vinberg, Maj; Erritzoe, David; Baaré, William; Holst, Klaus Kähler; Mortensen, Erik Lykke; Arfan, Haroon; Madsen, Jacob; Jernigan, Terry L; Kessing, Lars Vedel; Knudsen, Gitte Moos; Frøkjær, Vibe; Vinberg, Maj; Erritzøe, David; Baaré, William; Holst, Klaus Kähler; Mortensen, Erik Lykke; Arfan, Haroon; Madsen, Jacob; Jernigan, Terry L; Kessing, Lars Vedel; Knudsen, Gitte Moos.
I: European Neuropsychopharmacology, Bind 35, Nr. 5, 2010, s. 1129-37.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding
AU - Frøkjær, Vibe Gedsø
AU - Vinberg, Maj
AU - Erritzoe, David
AU - Baaré, William
AU - Holst, Klaus Kähler
AU - Mortensen, Erik Lykke
AU - Arfan, Haroon
AU - Madsen, Jacob
AU - Jernigan, Terry L
AU - Kessing, Lars Vedel
AU - Knudsen, Gitte Moos
AU - Frøkjær, Vibe
AU - Vinberg, Maj
AU - Erritzøe, David
AU - Baaré, William
AU - Holst, Klaus Kähler
AU - Mortensen, Erik Lykke
AU - Arfan, Haroon
AU - Madsen, Jacob
AU - Jernigan, Terry L
AU - Kessing, Lars Vedel
AU - Knudsen, Gitte Moos
PY - 2010
Y1 - 2010
N2 - Life stress is a robust risk factor for later development of mood disorders, particularly for individuals at familial risk. Likewise, scoring high on the personality trait neuroticism is associated with an increased risk for mood disorders. Neuroticism partly reflects stress vulnerability and is positively correlated to frontolimbic serotonin 2A (5-HT(2A)) receptor binding. Here, we investigate whether neuroticism interacts with familial risk in relation to frontolimbic 5-HT(2A) receptor binding. Twenty-one healthy twins with a co-twin history of mood disorder and 16 healthy twins without a co-twin history of mood disorder were included. They answered self-report personality questionnaires and underwent [(18)F]altanserin positron emission tomography. We found a significant interaction between neuroticism and familial risk in predicting the frontolimbic 5-HT(2A) receptor binding (p=0.026) in an analysis adjusting for age and body mass index. Within the high-risk group only, neuroticism and frontolimbic 5-HT(2A) receptor binding was positively associated (p=0.0037). In conclusion, our data indicate that familial risk and neuroticism interact in their relation to frontolimbic 5-HT(2A) receptor binding. These findings point at a plausible neurobiological link between genetic and personality risk factors and vulnerability to developing mood disorders. It contributes to our understanding of why some people at high risk develop mood disorders while others do not. We speculate that an increased stress reactivity in individuals at high familial risk for mood disorders might enhance the effect of neuroticism in shaping the impact of potential environmental stress and thereby influence serotonergic neurotransmission.
AB - Life stress is a robust risk factor for later development of mood disorders, particularly for individuals at familial risk. Likewise, scoring high on the personality trait neuroticism is associated with an increased risk for mood disorders. Neuroticism partly reflects stress vulnerability and is positively correlated to frontolimbic serotonin 2A (5-HT(2A)) receptor binding. Here, we investigate whether neuroticism interacts with familial risk in relation to frontolimbic 5-HT(2A) receptor binding. Twenty-one healthy twins with a co-twin history of mood disorder and 16 healthy twins without a co-twin history of mood disorder were included. They answered self-report personality questionnaires and underwent [(18)F]altanserin positron emission tomography. We found a significant interaction between neuroticism and familial risk in predicting the frontolimbic 5-HT(2A) receptor binding (p=0.026) in an analysis adjusting for age and body mass index. Within the high-risk group only, neuroticism and frontolimbic 5-HT(2A) receptor binding was positively associated (p=0.0037). In conclusion, our data indicate that familial risk and neuroticism interact in their relation to frontolimbic 5-HT(2A) receptor binding. These findings point at a plausible neurobiological link between genetic and personality risk factors and vulnerability to developing mood disorders. It contributes to our understanding of why some people at high risk develop mood disorders while others do not. We speculate that an increased stress reactivity in individuals at high familial risk for mood disorders might enhance the effect of neuroticism in shaping the impact of potential environmental stress and thereby influence serotonergic neurotransmission.
U2 - 10.1038/npp.2009.218
DO - 10.1038/npp.2009.218
M3 - Journal article
C2 - 20043006
VL - 35
SP - 1129
EP - 1137
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
SN - 0924-977X
IS - 5
ER -
ID: 19095948