Factors associated with HIV-1 virological failure in an outpatient clinic for HIV-infected people in Haiphong, Vietnam
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Factors associated with HIV-1 virological failure in an outpatient clinic for HIV-infected people in Haiphong, Vietnam. / Huong, D T M; Bannister, W; Phong, P T; Kirk, O; Peters, L; Huong, D T M; Bannister, W; Phong, P T; Kirk, O; Peters, L.
I: International Journal of S T D & AIDS, Bind 22, Nr. 11, 2011, s. 659-64.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Factors associated with HIV-1 virological failure in an outpatient clinic for HIV-infected people in Haiphong, Vietnam
AU - Huong, D T M
AU - Bannister, W
AU - Phong, P T
AU - Kirk, O
AU - Peters, L
AU - Huong, D T M
AU - Bannister, W
AU - Phong, P T
AU - Kirk, O
AU - Peters, L
PY - 2011
Y1 - 2011
N2 - The objective of our study was to investigate factors associated with virological failure in 100 consecutive HIV-1 infected Vietnamese adults who initiated antiretroviral therapy (ART) from June 2007 to June 2008. Data were collected from medical records, and a structured questionnaire was used in individual interviews to investigate factors associated with adherence to ART. Plasma HIV viral load was measured at the time of the interview. The median age was 35 years, 35% were women and heterosexual intercourse was the most common mode of HIV transmission (61%). After a median of 14 months since starting ART, 23% had detectable HIV-1 viral load (= 400 copies/mL). Patients who had developed a World Health Organization (WHO) clinical stage 4 condition at the time of initiation of ART were more likely to experience virological failure than those in stages 1-3, odds ratio (OR): 5.20 (95% confidence interval [CI] 1.34-20.11), P = 0.017. Patients who reported that their health status was evaluated by a physician at each visit were less likely to experience virological failure, OR: 0.02 (95% CI 0.00-0.24), P = 0.002.
AB - The objective of our study was to investigate factors associated with virological failure in 100 consecutive HIV-1 infected Vietnamese adults who initiated antiretroviral therapy (ART) from June 2007 to June 2008. Data were collected from medical records, and a structured questionnaire was used in individual interviews to investigate factors associated with adherence to ART. Plasma HIV viral load was measured at the time of the interview. The median age was 35 years, 35% were women and heterosexual intercourse was the most common mode of HIV transmission (61%). After a median of 14 months since starting ART, 23% had detectable HIV-1 viral load (= 400 copies/mL). Patients who had developed a World Health Organization (WHO) clinical stage 4 condition at the time of initiation of ART were more likely to experience virological failure than those in stages 1-3, odds ratio (OR): 5.20 (95% confidence interval [CI] 1.34-20.11), P = 0.017. Patients who reported that their health status was evaluated by a physician at each visit were less likely to experience virological failure, OR: 0.02 (95% CI 0.00-0.24), P = 0.002.
KW - Adult
KW - Ambulatory Care Facilities
KW - Anti-HIV Agents
KW - Antiretroviral Therapy, Highly Active
KW - Female
KW - HIV Infections
KW - HIV-1
KW - Humans
KW - Interviews as Topic
KW - Male
KW - Medication Adherence
KW - Questionnaires
KW - Risk Factors
KW - Treatment Failure
KW - Vietnam
KW - Viral Load
U2 - 10.1258/ijsa.2011.010515
DO - 10.1258/ijsa.2011.010515
M3 - Journal article
C2 - 22096052
VL - 22
SP - 659
EP - 664
JO - International Journal of S T D & A I D S
JF - International Journal of S T D & A I D S
SN - 0956-4624
IS - 11
ER -
ID: 38429838