The authors show that ISUP 2 histological grade obtained by multiparametric MRI biopsies targeted to the cancerous lesion is seldomly downgraded when compared with the RP specimen and suggest that MRI targeting does not lead to overdiagnosis [1]. Overdiagnosis is a term used to describe men who are diagnosed with a disease that will never develop into symptoms or death, which is not reported here. Moreover, some aspects of the article need of clarification. The authors state that the men included had no prior biopsies, however, in the Table, 210 men are reported with one or more prior biopsies. Furthermore, among the men with ISUP 2 on RP pathology, 60% is reported as pT0, indicating no cancer found in the specimen, and an additional 32% is reported with pT1, both findings need clarification