Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1: A Functional GLP-1–Renal Axis in Man
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Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1 : A Functional GLP-1–Renal Axis in Man. / Asmar, Ali; Cramon, Per K; Simonsen, Lene; Asmar, Meena; Sorensen, Charlotte M; Madsbad, Sten; Moro, Cedric; Hartmann, Bolette; Jensen, Boye L; Holst, Jens J; Bülow, Jens.
I: The Journal of clinical endocrinology and metabolism, Bind 104, Nr. 7, 07.2019, s. 2509–2519.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1
T2 - A Functional GLP-1–Renal Axis in Man
AU - Asmar, Ali
AU - Cramon, Per K
AU - Simonsen, Lene
AU - Asmar, Meena
AU - Sorensen, Charlotte M
AU - Madsbad, Sten
AU - Moro, Cedric
AU - Hartmann, Bolette
AU - Jensen, Boye L
AU - Holst, Jens J
AU - Bülow, Jens
N1 - Copyright © 2019 Endocrine Society.
PY - 2019/7
Y1 - 2019/7
N2 - PURPOSE: We have previously demonstrated that glucagon-like peptide (GLP)-1, does not affect renal hemodynamics or function under baseline conditions in healthy individuals and in patients with type 2 diabetes mellitus. However, it is possible that GLP-1 promotes natriuresis under conditions with addition of salt and water to the extracellular fluid. The present study was designed to investigate a possible GLP-1-renal axis, inducing natriuresis in healthy, volume loaded individuals.METHODS: Under fixed sodium intake, 8 healthy men were examined twice in random order during a 3-hour infusion of either GLP-1(1.5 pmol kg-1 min-1) or vehicle together with an intravenous infusion of 0.9% NaCl. Timed urine collections were conducted throughout the experiments. Renal plasma flow (RPF), glomerular filtration rate (GFR), and uptake/release of hormones and ions were measured using Fick's Principle.RESULTS: During GLP-1 infusion, urinary sodium and osmolar excretions increased significantly compared to vehicle. Plasma renin levels decreased similarly on both days, whereas angiotensin II (ANG II) levels decreased significantly only during GLP-1 infusion. RPF and GFR remained unchanged on both days.CONCLUSIONS: In volume loaded subjects, GLP-1 induces significant natriuresis, likely brought about via a tubular mechanism secondary to suppression of ANG II, independent of renal hemodynamics, supporting the existence of a GLP-1-renal axis.
AB - PURPOSE: We have previously demonstrated that glucagon-like peptide (GLP)-1, does not affect renal hemodynamics or function under baseline conditions in healthy individuals and in patients with type 2 diabetes mellitus. However, it is possible that GLP-1 promotes natriuresis under conditions with addition of salt and water to the extracellular fluid. The present study was designed to investigate a possible GLP-1-renal axis, inducing natriuresis in healthy, volume loaded individuals.METHODS: Under fixed sodium intake, 8 healthy men were examined twice in random order during a 3-hour infusion of either GLP-1(1.5 pmol kg-1 min-1) or vehicle together with an intravenous infusion of 0.9% NaCl. Timed urine collections were conducted throughout the experiments. Renal plasma flow (RPF), glomerular filtration rate (GFR), and uptake/release of hormones and ions were measured using Fick's Principle.RESULTS: During GLP-1 infusion, urinary sodium and osmolar excretions increased significantly compared to vehicle. Plasma renin levels decreased similarly on both days, whereas angiotensin II (ANG II) levels decreased significantly only during GLP-1 infusion. RPF and GFR remained unchanged on both days.CONCLUSIONS: In volume loaded subjects, GLP-1 induces significant natriuresis, likely brought about via a tubular mechanism secondary to suppression of ANG II, independent of renal hemodynamics, supporting the existence of a GLP-1-renal axis.
U2 - 10.1210/jc.2019-00004
DO - 10.1210/jc.2019-00004
M3 - Journal article
C2 - 30835273
VL - 104
SP - 2509
EP - 2519
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 7
ER -
ID: 214747974