TY - JOUR

T1 - Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes

AU - de Jong, Simone

AU - van Eijk, Kristel R

AU - Zeegers, Dave W L H

AU - Strengman, Eric

AU - Janson, Esther

AU - Veldink, Jan H

AU - van den Berg, Leonard H

AU - Cahn, Wiepke

AU - Kahn, René S

AU - Boks, Marco P M

AU - Ophoff, Roel A

AU - PGC Schizophrenia (GWAS) Consortium

AU - Werge, Thomas Mears

AU - Hansen, Thomas

AU - Ingason, Andrés

AU - Olsen, Line

AU - Thygesen, Johan Hilge

PY - 2012

Y1 - 2012

N2 - There is genetic evidence that schizophrenia is a polygenic disorder with a large number of loci of small effect on disease susceptibility. Genome-wide association studies (GWASs) of schizophrenia have had limited success, with the best finding at the MHC locus at chromosome 6p. A recent effort of the Psychiatric GWAS consortium (PGC) yielded five novel loci for schizophrenia. In this study, we aim to highlight additional schizophrenia susceptibility loci from the PGC study by combining the top association findings from the discovery stage (9394 schizophrenia cases and 12 462 controls) with expression QTLs (eQTLs) and differential gene expression in whole blood of schizophrenia patients and controls. We examined the 6192 single-nucleotide polymorphisms (SNPs) with significance threshold at P

AB - There is genetic evidence that schizophrenia is a polygenic disorder with a large number of loci of small effect on disease susceptibility. Genome-wide association studies (GWASs) of schizophrenia have had limited success, with the best finding at the MHC locus at chromosome 6p. A recent effort of the Psychiatric GWAS consortium (PGC) yielded five novel loci for schizophrenia. In this study, we aim to highlight additional schizophrenia susceptibility loci from the PGC study by combining the top association findings from the discovery stage (9394 schizophrenia cases and 12 462 controls) with expression QTLs (eQTLs) and differential gene expression in whole blood of schizophrenia patients and controls. We examined the 6192 single-nucleotide polymorphisms (SNPs) with significance threshold at P

U2 - 10.1038/ejhg.2012.38

DO - 10.1038/ejhg.2012.38

M3 - Journal article

C2 - 22433715

VL - 20

SP - 1004

EP - 1008

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

SN - 1018-4813

IS - 9

ER -