Expression of BKCa channels and the modulatory ß-subunits in the rat and porcine trigeminal ganglion

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Standard

Expression of BKCa channels and the modulatory ß-subunits in the rat and porcine trigeminal ganglion. / Wulf-Johansson, Helle; Hay-Schmidt, Anders; Poulsen, Asser Nyander; Klærke, Dan Arne; Olesen, Jes; Jansen-Olesen, Inger.

I: Brain Research, Bind 1292, 2009, s. 1-13.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wulf-Johansson, H, Hay-Schmidt, A, Poulsen, AN, Klærke, DA, Olesen, J & Jansen-Olesen, I 2009, 'Expression of BKCa channels and the modulatory ß-subunits in the rat and porcine trigeminal ganglion', Brain Research, bind 1292, s. 1-13. https://doi.org/10.1016/j.brainres.2009.07.047

APA

Wulf-Johansson, H., Hay-Schmidt, A., Poulsen, A. N., Klærke, D. A., Olesen, J., & Jansen-Olesen, I. (2009). Expression of BKCa channels and the modulatory ß-subunits in the rat and porcine trigeminal ganglion. Brain Research, 1292, 1-13. https://doi.org/10.1016/j.brainres.2009.07.047

Vancouver

Wulf-Johansson H, Hay-Schmidt A, Poulsen AN, Klærke DA, Olesen J, Jansen-Olesen I. Expression of BKCa channels and the modulatory ß-subunits in the rat and porcine trigeminal ganglion. Brain Research. 2009;1292:1-13. https://doi.org/10.1016/j.brainres.2009.07.047

Author

Wulf-Johansson, Helle ; Hay-Schmidt, Anders ; Poulsen, Asser Nyander ; Klærke, Dan Arne ; Olesen, Jes ; Jansen-Olesen, Inger. / Expression of BKCa channels and the modulatory ß-subunits in the rat and porcine trigeminal ganglion. I: Brain Research. 2009 ; Bind 1292. s. 1-13.

Bibtex

@article{f67138e0a83211debc73000ea68e967b,
title = "Expression of BKCa channels and the modulatory {\ss}-subunits in the rat and porcine trigeminal ganglion",
abstract = "Large conductance calcium-activated potassium (BK(Ca)) channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release. Migraine has been proposed to be a trigeminovascular disease involving the sensory trigeminal pathways and the cerebral arteries. We hypothesize that BK(Ca) channel alpha- and beta-subunits are present in the rat and porcine trigeminal ganglion (TG) thus enabling a role in migraine. BK(Ca) channel mRNA was detected using reverse transcription polymerase chain reaction (RT-PCR) and in situ hybridization. BK(Ca) channel protein was visualized by western blotting and histochemistry. The presence of the modulatory beta1-beta 4 subunit mRNAs was investigated using RT-PCR. beta1-, beta2- and beta 4-subunit mRNAs were expressed in rat TG whereas beta2- and beta 4-subunits were detected in porcine TG. Western blotting revealed beta2- and beta 4-subunit proteins in rat and porcine TG. The present study showed BK(Ca) channel expression in rat and porcine TG. The main modulatory beta-subunits detected in TG of both species were beta2- and beta 4-subunits.",
author = "Helle Wulf-Johansson and Anders Hay-Schmidt and Poulsen, {Asser Nyander} and Kl{\ae}rke, {Dan Arne} and Jes Olesen and Inger Jansen-Olesen",
year = "2009",
doi = "10.1016/j.brainres.2009.07.047",
language = "English",
volume = "1292",
pages = "1--13",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Expression of BKCa channels and the modulatory ß-subunits in the rat and porcine trigeminal ganglion

AU - Wulf-Johansson, Helle

AU - Hay-Schmidt, Anders

AU - Poulsen, Asser Nyander

AU - Klærke, Dan Arne

AU - Olesen, Jes

AU - Jansen-Olesen, Inger

PY - 2009

Y1 - 2009

N2 - Large conductance calcium-activated potassium (BK(Ca)) channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release. Migraine has been proposed to be a trigeminovascular disease involving the sensory trigeminal pathways and the cerebral arteries. We hypothesize that BK(Ca) channel alpha- and beta-subunits are present in the rat and porcine trigeminal ganglion (TG) thus enabling a role in migraine. BK(Ca) channel mRNA was detected using reverse transcription polymerase chain reaction (RT-PCR) and in situ hybridization. BK(Ca) channel protein was visualized by western blotting and histochemistry. The presence of the modulatory beta1-beta 4 subunit mRNAs was investigated using RT-PCR. beta1-, beta2- and beta 4-subunit mRNAs were expressed in rat TG whereas beta2- and beta 4-subunits were detected in porcine TG. Western blotting revealed beta2- and beta 4-subunit proteins in rat and porcine TG. The present study showed BK(Ca) channel expression in rat and porcine TG. The main modulatory beta-subunits detected in TG of both species were beta2- and beta 4-subunits.

AB - Large conductance calcium-activated potassium (BK(Ca)) channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release. Migraine has been proposed to be a trigeminovascular disease involving the sensory trigeminal pathways and the cerebral arteries. We hypothesize that BK(Ca) channel alpha- and beta-subunits are present in the rat and porcine trigeminal ganglion (TG) thus enabling a role in migraine. BK(Ca) channel mRNA was detected using reverse transcription polymerase chain reaction (RT-PCR) and in situ hybridization. BK(Ca) channel protein was visualized by western blotting and histochemistry. The presence of the modulatory beta1-beta 4 subunit mRNAs was investigated using RT-PCR. beta1-, beta2- and beta 4-subunit mRNAs were expressed in rat TG whereas beta2- and beta 4-subunits were detected in porcine TG. Western blotting revealed beta2- and beta 4-subunit proteins in rat and porcine TG. The present study showed BK(Ca) channel expression in rat and porcine TG. The main modulatory beta-subunits detected in TG of both species were beta2- and beta 4-subunits.

U2 - 10.1016/j.brainres.2009.07.047

DO - 10.1016/j.brainres.2009.07.047

M3 - Journal article

C2 - 19631627

VL - 1292

SP - 1

EP - 13

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -

ID: 14640468