TY - JOUR

T1 - Exposure to loud noise and risk of vestibular schwannoma

T2 - results from the INTERPHONE international case‒control study

AU - Deltour, Isabelle

AU - Schlehofer, Brigitte

AU - Massardier-Pilonchéry, Amélie

AU - Schlaefer, Klaus

AU - Armstrong, Bruce

AU - Giles, Graham G

AU - Siemiatycki, Jack

AU - Parent, Marie-Elise

AU - Krewski, Daniel

AU - McBride, Mary

AU - Johansen, Christoffer

AU - Auvinen, Anssi

AU - Salminen, Tiina

AU - Hours, Martine

AU - Montestrucq, Lucile

AU - Blettner, Maria

AU - Berg-Beckhoff, Gabriele

AU - Sadetzki, Siegal

AU - Chetrit, Angela

AU - Lagorio, Susanna

AU - Iavarone, Ivano

AU - Yamaguchi, Naohito

AU - Takebayashi, Toru

AU - Woodward, Alistair

AU - Cook, Angus

AU - Tynes, Tore

AU - Klaeboe, Lars

AU - Maria Feychting, Maria Feychting

AU - Lönn, Stefan

AU - Fleming, Sarah

AU - Swerdlow, Anthony J

AU - Schoemaker, Minouk J

AU - Moissonnier, Monika

AU - Kesminiene, Ausrele

AU - Cardis, Elisabeth

AU - Schüz, Joachim

AU - INTERPHONE Study Group

PY - 2019

Y1 - 2019

N2 - Objective Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000-2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure. Methods Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets. Results The OR for total work and leisure noise exposure was 1.6 (95% CI 1.4-1.9). OR were 1.5 (95% CI 1.3-1.9) for only occupational noise, 1.9 (95% CI 1.4-2.6) for only leisure noise and 1.7 (95% CI 1.2-2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise. Conclusion The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.

AB - Objective Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000-2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure. Methods Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets. Results The OR for total work and leisure noise exposure was 1.6 (95% CI 1.4-1.9). OR were 1.5 (95% CI 1.3-1.9) for only occupational noise, 1.9 (95% CI 1.4-2.6) for only leisure noise and 1.7 (95% CI 1.2-2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise. Conclusion The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.

U2 - 10.5271/sjweh.3781

DO - 10.5271/sjweh.3781

M3 - Journal article

C2 - 30614502

VL - 45

SP - 183

EP - 193

JO - Scandinavian Journal of Work, Environment & Health

JF - Scandinavian Journal of Work, Environment & Health

SN - 0355-3140

IS - 2

ER -