Excited-state dynamics of 4-hydroxyisoindoline-1,3-dione and its derivative as fluorescent probes
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Excited-state dynamics of 4-hydroxyisoindoline-1,3-dione and its derivative as fluorescent probes. / Zhao, Li; Jiang, Simin; He, Yanmei; Wu, Luling; James, Tony D.; Chen, Junsheng.
I: Physical Chemistry Chemical Physics, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Excited-state dynamics of 4-hydroxyisoindoline-1,3-dione and its derivative as fluorescent probes
AU - Zhao, Li
AU - Jiang, Simin
AU - He, Yanmei
AU - Wu, Luling
AU - James, Tony D.
AU - Chen, Junsheng
PY - 2024
Y1 - 2024
N2 - Fluorescent probes have become promising tools for monitoring the concentration of peroxynitrite, which is linked to many diseases. However, despite focusing on developing numerous peroxynitrite based fluorescent probes, limited emphasis is placed on their sensing mechanism. Here, we investigated the sensing mechanism of a peroxynitrite fluorescent probe, named BHID-Bpin, with a focus on the relevant excited state dynamics. The photoexcited BHID-Bpin relaxes to its ground state via an efficient nonradiative process (∼300 ps) due to the presence of a minimum energy conical intersection between its first excited state and ground state. However, upon reacting with peroxynitrite, the Bpin moiety is cleaved from BHID-Bpin and BHID is formed. The formed BHID exhibits strong dual band fluorescence which is caused by an ultrafast excited-state intramolecular proton transfer process (∼1 ps).
AB - Fluorescent probes have become promising tools for monitoring the concentration of peroxynitrite, which is linked to many diseases. However, despite focusing on developing numerous peroxynitrite based fluorescent probes, limited emphasis is placed on their sensing mechanism. Here, we investigated the sensing mechanism of a peroxynitrite fluorescent probe, named BHID-Bpin, with a focus on the relevant excited state dynamics. The photoexcited BHID-Bpin relaxes to its ground state via an efficient nonradiative process (∼300 ps) due to the presence of a minimum energy conical intersection between its first excited state and ground state. However, upon reacting with peroxynitrite, the Bpin moiety is cleaved from BHID-Bpin and BHID is formed. The formed BHID exhibits strong dual band fluorescence which is caused by an ultrafast excited-state intramolecular proton transfer process (∼1 ps).
U2 - 10.1039/D3CP05777A
DO - 10.1039/D3CP05777A
M3 - Journal article
JO - Physical Chemistry Chemical Physics
JF - Physical Chemistry Chemical Physics
SN - 1463-9076
ER -
ID: 390284500