Excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoring
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Excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoring. / Larsen, Bjørn Strøier; Aplin, Mark; Nielsen, Olav Wendelboe; Dominguez Vall-Lamora, Maria Helena; Høst, Nis Baun; Kristiansen, Ole Peter; Rasmusen, Hanne Kruuse; Davidsen, Ulla; Karlsen, Finn Michael; Højberg, Søren; Sajadieh, Ahmad.
I: Heart Rhythm O2, Bind 2, Nr. 3, 2021, s. 231-238.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoring
AU - Larsen, Bjørn Strøier
AU - Aplin, Mark
AU - Nielsen, Olav Wendelboe
AU - Dominguez Vall-Lamora, Maria Helena
AU - Høst, Nis Baun
AU - Kristiansen, Ole Peter
AU - Rasmusen, Hanne Kruuse
AU - Davidsen, Ulla
AU - Karlsen, Finn Michael
AU - Højberg, Søren
AU - Sajadieh, Ahmad
N1 - Publisher Copyright: © 2021 Heart Rhythm Society
PY - 2021
Y1 - 2021
N2 - Background: Excessive supraventricular ectopic activity (ESVEA), defined as ≥720 premature atrial contractions (PAC) per day or any runs of ≥20 PACs, has been proposed as a surrogate marker for paroxysmal atrial fibrillation (PAF). Objective: We aimed to estimate the prognostic impact of ESVEA on the future development of PAF in consecutive patients referred to ambulatory cardiac monitoring. Methods: The cohort consists of a population with comorbidities referred to 48-hour ambulatory electrocardiogram aged 30–98 (n = 1316) between 2009 and 2011. After exclusion of known or current atrial fibrillation (AF) (n = 527) and patients with pacemakers (n = 7), 782 patients were included, with a median follow-up of 8.1 years. Events of incident AF and death were retrieved from patient records. Results: Mean age was 58.6 ± 15.5 years and 56.5% were women. A total of 101 patients had ESVEA at baseline (12.9%). During follow-up, 69 (8.9%) developed incidental AF. Twenty-three patients with ESVEA developed AF (23%). Incidence rate of AF in patients with and without ESVEA was 37.1/1000 person-years and 9.1 per 1000 person-years, respectively (P < .001). ESVEA was associated with incident AF after adjustment for potential confounders in Cox regression analysis (hazard ratio [HR]: 2.39; 95% confidence interval [CI]: 1.40–4.09) and in competing risk analysis with death as competing risk (subdistribution HR: 2.35; 95% CI: 1.30–4.17). Conclusion: ESVEA increases the risk of incident AF substantially in a population referred to ambulatory cardiac monitoring.
AB - Background: Excessive supraventricular ectopic activity (ESVEA), defined as ≥720 premature atrial contractions (PAC) per day or any runs of ≥20 PACs, has been proposed as a surrogate marker for paroxysmal atrial fibrillation (PAF). Objective: We aimed to estimate the prognostic impact of ESVEA on the future development of PAF in consecutive patients referred to ambulatory cardiac monitoring. Methods: The cohort consists of a population with comorbidities referred to 48-hour ambulatory electrocardiogram aged 30–98 (n = 1316) between 2009 and 2011. After exclusion of known or current atrial fibrillation (AF) (n = 527) and patients with pacemakers (n = 7), 782 patients were included, with a median follow-up of 8.1 years. Events of incident AF and death were retrieved from patient records. Results: Mean age was 58.6 ± 15.5 years and 56.5% were women. A total of 101 patients had ESVEA at baseline (12.9%). During follow-up, 69 (8.9%) developed incidental AF. Twenty-three patients with ESVEA developed AF (23%). Incidence rate of AF in patients with and without ESVEA was 37.1/1000 person-years and 9.1 per 1000 person-years, respectively (P < .001). ESVEA was associated with incident AF after adjustment for potential confounders in Cox regression analysis (hazard ratio [HR]: 2.39; 95% confidence interval [CI]: 1.40–4.09) and in competing risk analysis with death as competing risk (subdistribution HR: 2.35; 95% CI: 1.30–4.17). Conclusion: ESVEA increases the risk of incident AF substantially in a population referred to ambulatory cardiac monitoring.
KW - Atrial fibrillation
KW - Epidemiology
KW - Premature atrial contractions
KW - Risk stratification
KW - Survival analysis
U2 - 10.1016/j.hroo.2021.04.002
DO - 10.1016/j.hroo.2021.04.002
M3 - Journal article
C2 - 34337573
AN - SCOPUS:85125836290
VL - 2
SP - 231
EP - 238
JO - Heart Rhythm O2
JF - Heart Rhythm O2
SN - 2666-5018
IS - 3
ER -
ID: 302052465