Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors. / Nickels, Stefan; Truong, Thérèse; Hein, Rebecca; Stevens, Kristen; Buck, Katharina; Behrens, Sabine; Eilber, Ursula; Schmidt, Martina; Häberle, Lothar; Vrieling, Alina; Gaudet, Mia; Figueroa, Jonine; Schoof, Nils; Spurdle, Amanda B; Rudolph, Anja; Fasching, Peter A; Hopper, John L; Makalic, Enes; Schmidt, Daniel F; Southey, Melissa C; Beckmann, Matthias W; Ekici, Arif B; Fletcher, Olivia; Gibson, Lorna; Silva, Isabel dos Santos; Peto, Julian; Humphreys, Manjeet K; Wang, Jean; Cordina-Duverger, Emilie; Menegaux, Florence; Nordestgaard, Børge G; Bojesen, Stig E; Lanng, Charlotte; Anton-Culver, Hoda; Ziogas, Argyrios; Bernstein, Leslie; Clarke, Christina A; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Brauch, Hiltrud; Brüning, Thomas; Harth, Volker; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Lambrechts, Diether; Smeets, Dominiek; GENICA Network.
I: P L o S Genetics (Online), Bind 9, Nr. 3, 03.2013, s. e1003284.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors
AU - Nickels, Stefan
AU - Truong, Thérèse
AU - Hein, Rebecca
AU - Stevens, Kristen
AU - Buck, Katharina
AU - Behrens, Sabine
AU - Eilber, Ursula
AU - Schmidt, Martina
AU - Häberle, Lothar
AU - Vrieling, Alina
AU - Gaudet, Mia
AU - Figueroa, Jonine
AU - Schoof, Nils
AU - Spurdle, Amanda B
AU - Rudolph, Anja
AU - Fasching, Peter A
AU - Hopper, John L
AU - Makalic, Enes
AU - Schmidt, Daniel F
AU - Southey, Melissa C
AU - Beckmann, Matthias W
AU - Ekici, Arif B
AU - Fletcher, Olivia
AU - Gibson, Lorna
AU - Silva, Isabel dos Santos
AU - Peto, Julian
AU - Humphreys, Manjeet K
AU - Wang, Jean
AU - Cordina-Duverger, Emilie
AU - Menegaux, Florence
AU - Nordestgaard, Børge G
AU - Bojesen, Stig E
AU - Lanng, Charlotte
AU - Anton-Culver, Hoda
AU - Ziogas, Argyrios
AU - Bernstein, Leslie
AU - Clarke, Christina A
AU - Brenner, Hermann
AU - Müller, Heiko
AU - Arndt, Volker
AU - Stegmaier, Christa
AU - Brauch, Hiltrud
AU - Brüning, Thomas
AU - Harth, Volker
AU - Mannermaa, Arto
AU - Kataja, Vesa
AU - Kosma, Veli-Matti
AU - Hartikainen, Jaana M
AU - Lambrechts, Diether
AU - Smeets, Dominiek
AU - GENICA Network
PY - 2013/3
Y1 - 2013/3
N2 - Various common genetic susceptibility loci have been identified for breast cancer; however, it is unclear how they combine with lifestyle/environmental risk factors to influence risk. We undertook an international collaborative study to assess gene-environment interaction for risk of breast cancer. Data from 24 studies of the Breast Cancer Association Consortium were pooled. Using up to 34,793 invasive breast cancers and 41,099 controls, we examined whether the relative risks associated with 23 single nucleotide polymorphisms were modified by 10 established environmental risk factors (age at menarche, parity, breastfeeding, body mass index, height, oral contraceptive use, menopausal hormone therapy use, alcohol consumption, cigarette smoking, physical activity) in women of European ancestry. We used logistic regression models stratified by study and adjusted for age and performed likelihood ratio tests to assess gene-environment interactions. All statistical tests were two-sided. We replicated previously reported potential interactions between LSP1-rs3817198 and parity (Pinteraction = 2.4 × 10(-6)) and between CASP8-rs17468277 and alcohol consumption (Pinteraction = 3.1 × 10(-4)). Overall, the per-allele odds ratio (95% confidence interval) for LSP1-rs3817198 was 1.08 (1.01-1.16) in nulliparous women and ranged from 1.03 (0.96-1.10) in parous women with one birth to 1.26 (1.16-1.37) in women with at least four births. For CASP8-rs17468277, the per-allele OR was 0.91 (0.85-0.98) in those with an alcohol intake of
AB - Various common genetic susceptibility loci have been identified for breast cancer; however, it is unclear how they combine with lifestyle/environmental risk factors to influence risk. We undertook an international collaborative study to assess gene-environment interaction for risk of breast cancer. Data from 24 studies of the Breast Cancer Association Consortium were pooled. Using up to 34,793 invasive breast cancers and 41,099 controls, we examined whether the relative risks associated with 23 single nucleotide polymorphisms were modified by 10 established environmental risk factors (age at menarche, parity, breastfeeding, body mass index, height, oral contraceptive use, menopausal hormone therapy use, alcohol consumption, cigarette smoking, physical activity) in women of European ancestry. We used logistic regression models stratified by study and adjusted for age and performed likelihood ratio tests to assess gene-environment interactions. All statistical tests were two-sided. We replicated previously reported potential interactions between LSP1-rs3817198 and parity (Pinteraction = 2.4 × 10(-6)) and between CASP8-rs17468277 and alcohol consumption (Pinteraction = 3.1 × 10(-4)). Overall, the per-allele odds ratio (95% confidence interval) for LSP1-rs3817198 was 1.08 (1.01-1.16) in nulliparous women and ranged from 1.03 (0.96-1.10) in parous women with one birth to 1.26 (1.16-1.37) in women with at least four births. For CASP8-rs17468277, the per-allele OR was 0.91 (0.85-0.98) in those with an alcohol intake of
U2 - 10.1371/journal.pgen.1003284
DO - 10.1371/journal.pgen.1003284
M3 - Journal article
C2 - 23544014
VL - 9
SP - e1003284
JO - P L o S Genetics
JF - P L o S Genetics
SN - 1553-7390
IS - 3
ER -
ID: 48509042