Evaluation of the enterovirus laboratory surveillance system in Denmark, 2010 to 2013
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Evaluation of the enterovirus laboratory surveillance system in Denmark, 2010 to 2013. / Condell, Orla; Midgley, Sofie; Christiansen, C B; Chen, M; Nielsen, X Chen; Ellermann-Eriksen, S; Mølvadgaard, M; Schønning, K; Vermedal Hoegh, Silje; Andersen, P H; Voldstedlund, Marianne; Fischer, T K.
I: Eurosurveillance, Bind 21, Nr. 18, 3, 05.05.2016, s. 1-12.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Evaluation of the enterovirus laboratory surveillance system in Denmark, 2010 to 2013
AU - Condell, Orla
AU - Midgley, Sofie
AU - Christiansen, C B
AU - Chen, M
AU - Nielsen, X Chen
AU - Ellermann-Eriksen, S
AU - Mølvadgaard, M
AU - Schønning, K
AU - Vermedal Hoegh, Silje
AU - Andersen, P H
AU - Voldstedlund, Marianne
AU - Fischer, T K
PY - 2016/5/5
Y1 - 2016/5/5
N2 - The primary aim of the Danish enterovirus (EV) surveillance system is to document absence of poliovirus infection. The conflict in Syria has left many children unvaccinated and movement from areas with polio cases to Europe calls for increased awareness to detect and respond to virus-transmission in a timely manner. We evaluate the national EV laboratory surveillance, to generate recommendations for system strengthening. The system was analysed for completeness of viral typing analysis and clinical information and timeliness of specimen collection, laboratory results and reporting of clinical information. Of 23,720 specimens screened, 2,202 (9.3%) were EV-positive. Submission of cerebrospinal fluid and faecal specimens from primary diagnostic laboratories was 79.5% complete (845/1,063), and varied by laboratory and patient age. EV genotypes were determined in 68.5% (979/1,430) of laboratory-confirmed cases, clinical information was available for 63.1% (903/1,430). Primary diagnostic results were available after a median of 1.4 days, typing results after 17 days, detailed clinical information after 33 days. The large number of samples typed demonstrated continued monitoring of EV-circulation in Denmark. The system could be strengthened by increasing the collection of supplementary faecal specimens, improving communication with primary diagnostic laboratories, adapting the laboratory typing methodology and collecting clinical information with electronic forms.
AB - The primary aim of the Danish enterovirus (EV) surveillance system is to document absence of poliovirus infection. The conflict in Syria has left many children unvaccinated and movement from areas with polio cases to Europe calls for increased awareness to detect and respond to virus-transmission in a timely manner. We evaluate the national EV laboratory surveillance, to generate recommendations for system strengthening. The system was analysed for completeness of viral typing analysis and clinical information and timeliness of specimen collection, laboratory results and reporting of clinical information. Of 23,720 specimens screened, 2,202 (9.3%) were EV-positive. Submission of cerebrospinal fluid and faecal specimens from primary diagnostic laboratories was 79.5% complete (845/1,063), and varied by laboratory and patient age. EV genotypes were determined in 68.5% (979/1,430) of laboratory-confirmed cases, clinical information was available for 63.1% (903/1,430). Primary diagnostic results were available after a median of 1.4 days, typing results after 17 days, detailed clinical information after 33 days. The large number of samples typed demonstrated continued monitoring of EV-circulation in Denmark. The system could be strengthened by increasing the collection of supplementary faecal specimens, improving communication with primary diagnostic laboratories, adapting the laboratory typing methodology and collecting clinical information with electronic forms.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Child
KW - Child, Preschool
KW - Clinical Laboratory Techniques
KW - Denmark
KW - Disease Eradication
KW - Disease Notification
KW - Enterovirus
KW - Enterovirus Infections
KW - Female
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Middle Aged
KW - Population Surveillance
KW - Prevalence
KW - Quality Assurance, Health Care
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Young Adult
KW - Evaluation Studies
KW - Journal Article
U2 - 10.2807/1560-7917.ES.2016.21.18.30218
DO - 10.2807/1560-7917.ES.2016.21.18.30218
M3 - Journal article
C2 - 27173593
VL - 21
SP - 1
EP - 12
JO - Eurosurveillance
JF - Eurosurveillance
SN - 1025-496X
IS - 18
M1 - 3
ER -
ID: 176668115