Evaluation of the clinical significance of long non-coding RNA MALAT1 genetic variants in human lung adenocarcinoma
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Evaluation of the clinical significance of long non-coding RNA MALAT1 genetic variants in human lung adenocarcinoma. / Lin, Shu Hui; Lu, Jeng Wei; Hsieh, Wang Ting; Chou, Ying Erh; Su, Tzu Cheng; Tsai, Tun Jen; Tsai, Yun Jung; Yang, Po Jen; Yang, Shun Fa.
I: Aging, Bind 16, Nr. 6, 100532, 2024, s. 5740-5750.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Evaluation of the clinical significance of long non-coding RNA MALAT1 genetic variants in human lung adenocarcinoma
AU - Lin, Shu Hui
AU - Lu, Jeng Wei
AU - Hsieh, Wang Ting
AU - Chou, Ying Erh
AU - Su, Tzu Cheng
AU - Tsai, Tun Jen
AU - Tsai, Yun Jung
AU - Yang, Po Jen
AU - Yang, Shun Fa
N1 - Publisher Copyright: © 2024 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2024
Y1 - 2024
N2 - Lung adenocarcinoma (LUAD) is the most frequent histological subtype of lung cancer, which is the most common malignant tumor and the main cause of cancer-related mortality globally. Recent reports revealed that long non-coding RNA (lncRNA) of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays a crucial role in tumorigenesis and metastasis development in lung cancer. However, the contribution of MALAT1 genetic variants to the development of LUAD is unclear, especially in epidermal growth factor receptor (EGFR) mutation status. In this study, 272 LADC patients with different EGFR status were recruited to dissect the allelic discrimination of the MALAT1 polymorphisms at rs3200401, rs619586, and rs1194338. The findings of the study showed that MALAT1 polymorphisms rs3200401, rs619586, and rs1194338 were not associated to LUAD susceptibility; however, rs3200401 polymorphisms was significantly correlated to EGFR wild-type status and tumor stages in LUAD patients in dominant model (p=0.016). Further analyses using the datasets from The Cancer Genome Atlas (TCGA) revealed that lower MALAT1 mRNA levels were associated with the advanced stage, and lymph node metastasis in LADC patients. In conclusion, our results showed that MALAT1 rs3200401 polymorphisms dramatically raised the probability of LUAD development.
AB - Lung adenocarcinoma (LUAD) is the most frequent histological subtype of lung cancer, which is the most common malignant tumor and the main cause of cancer-related mortality globally. Recent reports revealed that long non-coding RNA (lncRNA) of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays a crucial role in tumorigenesis and metastasis development in lung cancer. However, the contribution of MALAT1 genetic variants to the development of LUAD is unclear, especially in epidermal growth factor receptor (EGFR) mutation status. In this study, 272 LADC patients with different EGFR status were recruited to dissect the allelic discrimination of the MALAT1 polymorphisms at rs3200401, rs619586, and rs1194338. The findings of the study showed that MALAT1 polymorphisms rs3200401, rs619586, and rs1194338 were not associated to LUAD susceptibility; however, rs3200401 polymorphisms was significantly correlated to EGFR wild-type status and tumor stages in LUAD patients in dominant model (p=0.016). Further analyses using the datasets from The Cancer Genome Atlas (TCGA) revealed that lower MALAT1 mRNA levels were associated with the advanced stage, and lymph node metastasis in LADC patients. In conclusion, our results showed that MALAT1 rs3200401 polymorphisms dramatically raised the probability of LUAD development.
KW - EGFR
KW - lung adenocarcinoma
KW - MALAT1
KW - single nucleotide polymorphism
U2 - 10.18632/aging.205675
DO - 10.18632/aging.205675
M3 - Journal article
C2 - 38517388
AN - SCOPUS:85190143627
VL - 16
SP - 5740
EP - 5750
JO - Aging
JF - Aging
SN - 1945-4589
IS - 6
M1 - 100532
ER -
ID: 389550415