Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models
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Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models. / Stærk-Østergaard, Jacob; Kirkeby, Carsten; Christiansen, Lasse E.; Andersen, Michael A.; Møller, Camilla H.; Voldstedlund, Marianne; Denwood, Matthew J.
I: Journal of Medical Virology, Bind 94, Nr. 10, 2022, s. 4754-4761.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Evaluation of diagnostic test procedures for SARS-CoV-2 using latent class models
AU - Stærk-Østergaard, Jacob
AU - Kirkeby, Carsten
AU - Christiansen, Lasse E.
AU - Andersen, Michael A.
AU - Møller, Camilla H.
AU - Voldstedlund, Marianne
AU - Denwood, Matthew J.
N1 - Publisher Copyright: © 2022 The Authors. Journal of Medical Virology Published by Wiley Periodicals LLC.
PY - 2022
Y1 - 2022
N2 - Polymerase chain reaction (PCR) and antigen tests have been used extensively for screening during the severe acute respiratory syndrome coronavirus 2 pandemics. However, the real-world sensitivity and specificity of the two testing procedures in the field have not yet been estimated without assuming that the PCR constitutes a gold standard test. We use latent class models to estimate the in situ performance of both tests using data from the Danish national registries. We find that the specificity of both tests is very high (>99.7%), while the sensitivities are 95.7% (95% confidence interval [CI]: 92.8%–98.4%) and 53.8% (95% CI: 49.8%–57.9%) for the PCR and antigen tests, respectively. These findings have implications for the use of confirmatory PCR tests following a positive antigen test result: we estimate that serial testing is counterproductive at higher prevalence levels.
AB - Polymerase chain reaction (PCR) and antigen tests have been used extensively for screening during the severe acute respiratory syndrome coronavirus 2 pandemics. However, the real-world sensitivity and specificity of the two testing procedures in the field have not yet been estimated without assuming that the PCR constitutes a gold standard test. We use latent class models to estimate the in situ performance of both tests using data from the Danish national registries. We find that the specificity of both tests is very high (>99.7%), while the sensitivities are 95.7% (95% confidence interval [CI]: 92.8%–98.4%) and 53.8% (95% CI: 49.8%–57.9%) for the PCR and antigen tests, respectively. These findings have implications for the use of confirmatory PCR tests following a positive antigen test result: we estimate that serial testing is counterproductive at higher prevalence levels.
KW - biostatistics and bioinformatics
KW - epidemiology
KW - SARS coronavirus
KW - test statistics
KW - virus classification
U2 - 10.1002/jmv.27943
DO - 10.1002/jmv.27943
M3 - Journal article
C2 - 35713189
AN - SCOPUS:85132385626
VL - 94
SP - 4754
EP - 4761
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 10
ER -
ID: 313376563