Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". / Johnatty, Sharon E; Beesley, Jonathan; Chen, Xiaoqing; Macgregor, Stuart; Duffy, David L; Spurdle, Amanda B; deFazio, Anna; Gava, Natalie; Webb, Penelope M; Rossing, Mary Anne; Doherty, Jennifer Anne; Goodman, Marc T; Lurie, Galina; Thompson, Pamela J; Wilkens, Lynne R; Ness, Roberta B; Moysich, Kirsten B; Chang-Claude, Jenny; Wang-Gohrke, Shan; Cramer, Daniel W; Terry, Kathryn L; Hankinson, Susan E; Tworoger, Shelley S; Garcia-Closas, Montserrat; Yang, Hannah; Lissowska, Jolanta; Chanock, Stephen J; Pharoah, Paul D; Song, Honglin; Whitemore, Alice S; Pearce, Celeste L; Stram, Daniel O; Wu, Anna H; Pike, Malcolm C; Gayther, Simon A; Ramus, Susan J; Menon, Usha; Gentry-Maharaj, Aleksandra; Anton-Culver, Hoda; Ziogas, Argyrios; Hogdall, Estrid; Kjaer, Susanne K; Hogdall, Claus; Berchuck, Andrew; Schildkraut, Joellen M; Iversen, Edwin S; Moorman, Patricia G; Phelan, Catherine M; Sellers, Thomas A; Cunningham, Julie M; Ovarian Cancer Association Consortium.
I: P L o S Genetics, Bind 6, Nr. 7, 01.07.2010, s. e1001016.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"
AU - Johnatty, Sharon E
AU - Beesley, Jonathan
AU - Chen, Xiaoqing
AU - Macgregor, Stuart
AU - Duffy, David L
AU - Spurdle, Amanda B
AU - deFazio, Anna
AU - Gava, Natalie
AU - Webb, Penelope M
AU - Rossing, Mary Anne
AU - Doherty, Jennifer Anne
AU - Goodman, Marc T
AU - Lurie, Galina
AU - Thompson, Pamela J
AU - Wilkens, Lynne R
AU - Ness, Roberta B
AU - Moysich, Kirsten B
AU - Chang-Claude, Jenny
AU - Wang-Gohrke, Shan
AU - Cramer, Daniel W
AU - Terry, Kathryn L
AU - Hankinson, Susan E
AU - Tworoger, Shelley S
AU - Garcia-Closas, Montserrat
AU - Yang, Hannah
AU - Lissowska, Jolanta
AU - Chanock, Stephen J
AU - Pharoah, Paul D
AU - Song, Honglin
AU - Whitemore, Alice S
AU - Pearce, Celeste L
AU - Stram, Daniel O
AU - Wu, Anna H
AU - Pike, Malcolm C
AU - Gayther, Simon A
AU - Ramus, Susan J
AU - Menon, Usha
AU - Gentry-Maharaj, Aleksandra
AU - Anton-Culver, Hoda
AU - Ziogas, Argyrios
AU - Hogdall, Estrid
AU - Kjaer, Susanne K
AU - Hogdall, Claus
AU - Berchuck, Andrew
AU - Schildkraut, Joellen M
AU - Iversen, Edwin S
AU - Moorman, Patricia G
AU - Phelan, Catherine M
AU - Sellers, Thomas A
AU - Cunningham, Julie M
AU - Ovarian Cancer Association Consortium
PY - 2010/7/1
Y1 - 2010/7/1
N2 - We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleotide polymorphisms (SNPs) in 173 genes involved in stromal epithelial interactions in the Ovarian Cancer Association Consortium (OCAC). In the discovery stage, cases with epithelial ovarian cancer (n=675) and controls (n=1,162) were genotyped at 1,536 SNPs using an Illumina GoldenGate assay. Based on Positive Predictive Value estimates, three SNPs-PODXL rs1013368, ITGA6 rs13027811, and MMP3 rs522616-were selected for replication using TaqMan genotyping in up to 3,059 serous invasive cases and 8,905 controls from 16 OCAC case-control studies. An additional 18 SNPs with Pper-alleleor=0.5). However genotypes at TERT rs7726159 were associated with ovarian cancer risk in the smaller, five-study replication study (Pper-allele=0.03). Combined analysis of the discovery and replication sets for this TERT SNP showed an increased risk of serous ovarian cancer among non-Hispanic whites [adj. ORper-allele 1.14 (1.04-1.24) p=0.003]. Our study adds to the growing evidence that, like the 8q24 locus, the telomerase reverse transcriptase locus at 5p15.33, is a general cancer susceptibility locus.
AB - We hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage approach to evaluate common single nucleotide polymorphisms (SNPs) in 173 genes involved in stromal epithelial interactions in the Ovarian Cancer Association Consortium (OCAC). In the discovery stage, cases with epithelial ovarian cancer (n=675) and controls (n=1,162) were genotyped at 1,536 SNPs using an Illumina GoldenGate assay. Based on Positive Predictive Value estimates, three SNPs-PODXL rs1013368, ITGA6 rs13027811, and MMP3 rs522616-were selected for replication using TaqMan genotyping in up to 3,059 serous invasive cases and 8,905 controls from 16 OCAC case-control studies. An additional 18 SNPs with Pper-alleleor=0.5). However genotypes at TERT rs7726159 were associated with ovarian cancer risk in the smaller, five-study replication study (Pper-allele=0.03). Combined analysis of the discovery and replication sets for this TERT SNP showed an increased risk of serous ovarian cancer among non-Hispanic whites [adj. ORper-allele 1.14 (1.04-1.24) p=0.003]. Our study adds to the growing evidence that, like the 8q24 locus, the telomerase reverse transcriptase locus at 5p15.33, is a general cancer susceptibility locus.
U2 - http://dx.doi.org/10.1371/journal.pgen.1001016
DO - http://dx.doi.org/10.1371/journal.pgen.1001016
M3 - Journal article
VL - 6
SP - e1001016
JO - P L o S Genetics
JF - P L o S Genetics
SN - 1553-7390
IS - 7
ER -
ID: 34157908