Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

Standard

Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture. / Stenbæk, Dea Siggaard; Einarsdottir, H S; Goregliad-Fjaellingsdal, T; Knudsen, Gitte M.; Frokjaer, V. G.; Hasselbalch, S G.

I: European Neuropsychopharmacology, Bind 26, Nr. 1, 01.2016, s. 147-9.

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

Harvard

Stenbæk, DS, Einarsdottir, HS, Goregliad-Fjaellingsdal, T, Knudsen, GM, Frokjaer, VG & Hasselbalch, SG 2016, 'Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture', European Neuropsychopharmacology, bind 26, nr. 1, s. 147-9. https://doi.org/10.1016/j.euroneuro.2015.11.010

APA

Stenbæk, D. S., Einarsdottir, H. S., Goregliad-Fjaellingsdal, T., Knudsen, G. M., Frokjaer, V. G., & Hasselbalch, S. G. (2016). Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture. European Neuropsychopharmacology, 26(1), 147-9. https://doi.org/10.1016/j.euroneuro.2015.11.010

Vancouver

Stenbæk DS, Einarsdottir HS, Goregliad-Fjaellingsdal T, Knudsen GM, Frokjaer VG, Hasselbalch SG. Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture. European Neuropsychopharmacology. 2016 jan.;26(1):147-9. https://doi.org/10.1016/j.euroneuro.2015.11.010

Author

Stenbæk, Dea Siggaard ; Einarsdottir, H S ; Goregliad-Fjaellingsdal, T ; Knudsen, Gitte M. ; Frokjaer, V. G. ; Hasselbalch, S G. / Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture. I: European Neuropsychopharmacology. 2016 ; Bind 26, Nr. 1. s. 147-9.

Bibtex

@article{236ef6db463a429c81219c3495850743,

title = "Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture",

abstract = "Acute Tryptophan Depletion (ATD) is a dietary method used to modulate central 5-HT to study the effects of temporarily reduced 5-HT synthesis. The aim of this study is to evaluate a novel method of ATD using a gelatin-based collagen peptide (CP) mixture. We administered CP-Trp or CP+Trp mixtures to 29 healthy volunteers; 13 from a randomized, double-blinded crossover study and sixteen from a randomized, double-blinded study run in our laboratory. Plasma amino acids, mood, side effects, cortisol concentrations, mean arterial blood pressure and heart rate were measured at multiple time-points. Repeated measures analysis of variance and Wilcoxon or Mann-Whitney U non-parametric tests were used to analyze the effects of intervention. Intake of the CP-Trp mixture efficiently reduced plasma Trp; however, the CP+Trp mixture induced a large significant increase in plasma Trp. No other significant effects of CP-Trp compared to CP+Trp were observed. The transient increase in plasma Trp after CP+Trp may impair comparison to the CP-Trp and we therefore recommend in future studies to use a smaller dose of Trp supplement to the CP mixture.",

keywords = "Journal Article, Research Support, Non-U.S. Gov't",

author = "Stenb{\ae}k, {Dea Siggaard} and Einarsdottir, {H S} and T Goregliad-Fjaellingsdal and Knudsen, {Gitte M.} and Frokjaer, {V. G.} and Hasselbalch, {S G}",

year = "2016",

month = jan,

doi = "10.1016/j.euroneuro.2015.11.010",

language = "English",

volume = "26",

pages = "147--9",

journal = "European Neuropsychopharmacology",

issn = "0924-977X",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture

AU - Stenbæk, Dea Siggaard

AU - Einarsdottir, H S

AU - Goregliad-Fjaellingsdal, T

AU - Knudsen, Gitte M.

AU - Frokjaer, V. G.

AU - Hasselbalch, S G

PY - 2016/1

Y1 - 2016/1

N2 - Acute Tryptophan Depletion (ATD) is a dietary method used to modulate central 5-HT to study the effects of temporarily reduced 5-HT synthesis. The aim of this study is to evaluate a novel method of ATD using a gelatin-based collagen peptide (CP) mixture. We administered CP-Trp or CP+Trp mixtures to 29 healthy volunteers; 13 from a randomized, double-blinded crossover study and sixteen from a randomized, double-blinded study run in our laboratory. Plasma amino acids, mood, side effects, cortisol concentrations, mean arterial blood pressure and heart rate were measured at multiple time-points. Repeated measures analysis of variance and Wilcoxon or Mann-Whitney U non-parametric tests were used to analyze the effects of intervention. Intake of the CP-Trp mixture efficiently reduced plasma Trp; however, the CP+Trp mixture induced a large significant increase in plasma Trp. No other significant effects of CP-Trp compared to CP+Trp were observed. The transient increase in plasma Trp after CP+Trp may impair comparison to the CP-Trp and we therefore recommend in future studies to use a smaller dose of Trp supplement to the CP mixture.

AB - Acute Tryptophan Depletion (ATD) is a dietary method used to modulate central 5-HT to study the effects of temporarily reduced 5-HT synthesis. The aim of this study is to evaluate a novel method of ATD using a gelatin-based collagen peptide (CP) mixture. We administered CP-Trp or CP+Trp mixtures to 29 healthy volunteers; 13 from a randomized, double-blinded crossover study and sixteen from a randomized, double-blinded study run in our laboratory. Plasma amino acids, mood, side effects, cortisol concentrations, mean arterial blood pressure and heart rate were measured at multiple time-points. Repeated measures analysis of variance and Wilcoxon or Mann-Whitney U non-parametric tests were used to analyze the effects of intervention. Intake of the CP-Trp mixture efficiently reduced plasma Trp; however, the CP+Trp mixture induced a large significant increase in plasma Trp. No other significant effects of CP-Trp compared to CP+Trp were observed. The transient increase in plasma Trp after CP+Trp may impair comparison to the CP-Trp and we therefore recommend in future studies to use a smaller dose of Trp supplement to the CP mixture.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.euroneuro.2015.11.010

DO - 10.1016/j.euroneuro.2015.11.010

M3 - Letter

C2 - 26655163

VL - 26

SP - 147

EP - 149

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

IS - 1

ER -

ID: 164513305