Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture
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Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture. / Stenbæk, Dea Siggaard; Einarsdottir, H S; Goregliad-Fjaellingsdal, T; Knudsen, Gitte M.; Frokjaer, V. G.; Hasselbalch, S G.
I: European Neuropsychopharmacology, Bind 26, Nr. 1, 01.2016, s. 147-9.Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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TY - JOUR
T1 - Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture
AU - Stenbæk, Dea Siggaard
AU - Einarsdottir, H S
AU - Goregliad-Fjaellingsdal, T
AU - Knudsen, Gitte M.
AU - Frokjaer, V. G.
AU - Hasselbalch, S G
N1 - Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved.
PY - 2016/1
Y1 - 2016/1
N2 - Acute Tryptophan Depletion (ATD) is a dietary method used to modulate central 5-HT to study the effects of temporarily reduced 5-HT synthesis. The aim of this study is to evaluate a novel method of ATD using a gelatin-based collagen peptide (CP) mixture. We administered CP-Trp or CP+Trp mixtures to 29 healthy volunteers; 13 from a randomized, double-blinded crossover study and sixteen from a randomized, double-blinded study run in our laboratory. Plasma amino acids, mood, side effects, cortisol concentrations, mean arterial blood pressure and heart rate were measured at multiple time-points. Repeated measures analysis of variance and Wilcoxon or Mann-Whitney U non-parametric tests were used to analyze the effects of intervention. Intake of the CP-Trp mixture efficiently reduced plasma Trp; however, the CP+Trp mixture induced a large significant increase in plasma Trp. No other significant effects of CP-Trp compared to CP+Trp were observed. The transient increase in plasma Trp after CP+Trp may impair comparison to the CP-Trp and we therefore recommend in future studies to use a smaller dose of Trp supplement to the CP mixture.
AB - Acute Tryptophan Depletion (ATD) is a dietary method used to modulate central 5-HT to study the effects of temporarily reduced 5-HT synthesis. The aim of this study is to evaluate a novel method of ATD using a gelatin-based collagen peptide (CP) mixture. We administered CP-Trp or CP+Trp mixtures to 29 healthy volunteers; 13 from a randomized, double-blinded crossover study and sixteen from a randomized, double-blinded study run in our laboratory. Plasma amino acids, mood, side effects, cortisol concentrations, mean arterial blood pressure and heart rate were measured at multiple time-points. Repeated measures analysis of variance and Wilcoxon or Mann-Whitney U non-parametric tests were used to analyze the effects of intervention. Intake of the CP-Trp mixture efficiently reduced plasma Trp; however, the CP+Trp mixture induced a large significant increase in plasma Trp. No other significant effects of CP-Trp compared to CP+Trp were observed. The transient increase in plasma Trp after CP+Trp may impair comparison to the CP-Trp and we therefore recommend in future studies to use a smaller dose of Trp supplement to the CP mixture.
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.euroneuro.2015.11.010
DO - 10.1016/j.euroneuro.2015.11.010
M3 - Letter
C2 - 26655163
VL - 26
SP - 147
EP - 149
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
SN - 0924-977X
IS - 1
ER -
ID: 164513305