Evaluation of a neurodevelopmental model of schizophrenia - Early postnatal PCP treatment in attentional set-shifting
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Phencyclidine (PCP) was administered to male and female Lister hooded rats on postnatal days (PND) 7, 9 and 11. All PCP animals tested in adulthood (PND 53-93) showed deficits in cognitive flexibility, specifically in their ability to shift attentional set, compared to controls. This novel finding is reminiscent of the impairment observed in schizophrenia patients, and supports the validity of the early postnatal PCP regimen as a disease-like model. (c) 2008 Elsevier B.V. All rights reserved
Udgivelsesdato: 2008
Udgivelsesdato: 2008
Originalsprog | Engelsk |
---|---|
Tidsskrift | Behavioural Brain Research |
Vol/bind | 190 |
Udgave nummer | 1 |
Sider (fra-til) | 160-163 |
Antal sider | 3 |
ISSN | 0166-4328 |
Status | Udgivet - 2008 |
Bibliografisk note
JEnglishArticleBroberg, BV, H Lundbeck & Co AS, Dept Psychopharmacol, Ottilliavej 9, DK-2500 Copenhagen, Denmarkbbs@lundbeck.com351ELSEVIER SCIENCE BVAMSTERDAMPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSBEHAV BRAIN RESJUN 26Discipline: Behavioral Sciences; Neurosciences299PF
ID: 13858627