Ethnic coefficients for glomerular filtration rate estimation by the Modification of Diet in Renal Disease study equations in the Korean population
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Ethnic coefficients for glomerular filtration rate estimation by the Modification of Diet in Renal Disease study equations in the Korean population. / Lee, Chung Sik; Cha, Ran-hui; Lim, Youn-Hee; Kim, Ho; Song, Ka Heon; Gu, Namyi; Yu, Kyung Sang; Lim, Chun Soo; Han, Jin Suk; Kim, Suhnggwon; Kim, Yon Su.
I: Journal of Korean Medical Science, Bind 25, Nr. 11, 2010, s. 1616-25.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Ethnic coefficients for glomerular filtration rate estimation by the Modification of Diet in Renal Disease study equations in the Korean population
AU - Lee, Chung Sik
AU - Cha, Ran-hui
AU - Lim, Youn-Hee
AU - Kim, Ho
AU - Song, Ka Heon
AU - Gu, Namyi
AU - Yu, Kyung Sang
AU - Lim, Chun Soo
AU - Han, Jin Suk
AU - Kim, Suhnggwon
AU - Kim, Yon Su
PY - 2010
Y1 - 2010
N2 - Race and ethnicity are influential in estimating glomerular filtration rate (GFR). We aimed to find the Korean coefficients for the Modification of Diet in Renal Disease (MDRD) study equations and to obtain novel proper estimation equations. Reference GFR was measured by systemic inulin clearance. Serum creatinine (SCr) values were measured by the alkaline picrate Jaffé kinetic method, then, recalibrated to CX3 analyzer and to isotope dilution mass spectrometry (IDMS). The Korean coefficients for the 4 and 6 variable MDRD and IDMS MDRD study equations based on the SCr recalibrated to CX3 and to IDMS were 0.73989/0.74254 and 0.99096/0.9554, respectively. Coefficients for the 4 and 6 variable MDRD equations based on the SCr measured by Jaffé method were 1.09825 and 1.04334, respectively. The modified equations showed better performances than the original equations. The novel 4 variable equations for Korean based on the SCr measured and recalibrated to IDMS were 107.904×SCr(-1.009)×age(-0.02) (×0.667, if woman) and 87.832×SCr(-0.882)×age(0.01) (×0.653, if woman), respectively. Modified estimations of the MDRD and IDMS MDRD study equations with ethnic coefficients and the novel equations improve the performance of GFR estimation for the overall renal function.
AB - Race and ethnicity are influential in estimating glomerular filtration rate (GFR). We aimed to find the Korean coefficients for the Modification of Diet in Renal Disease (MDRD) study equations and to obtain novel proper estimation equations. Reference GFR was measured by systemic inulin clearance. Serum creatinine (SCr) values were measured by the alkaline picrate Jaffé kinetic method, then, recalibrated to CX3 analyzer and to isotope dilution mass spectrometry (IDMS). The Korean coefficients for the 4 and 6 variable MDRD and IDMS MDRD study equations based on the SCr recalibrated to CX3 and to IDMS were 0.73989/0.74254 and 0.99096/0.9554, respectively. Coefficients for the 4 and 6 variable MDRD equations based on the SCr measured by Jaffé method were 1.09825 and 1.04334, respectively. The modified equations showed better performances than the original equations. The novel 4 variable equations for Korean based on the SCr measured and recalibrated to IDMS were 107.904×SCr(-1.009)×age(-0.02) (×0.667, if woman) and 87.832×SCr(-0.882)×age(0.01) (×0.653, if woman), respectively. Modified estimations of the MDRD and IDMS MDRD study equations with ethnic coefficients and the novel equations improve the performance of GFR estimation for the overall renal function.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Algorithms
KW - Creatinine/blood
KW - Diet
KW - Female
KW - Glomerular Filtration Rate
KW - Humans
KW - Inulin/metabolism
KW - Kidney Diseases/ethnology
KW - Male
KW - Mass Spectrometry
KW - Middle Aged
KW - Republic of Korea/ethnology
U2 - 10.3346/jkms.2010.25.11.1616
DO - 10.3346/jkms.2010.25.11.1616
M3 - Journal article
C2 - 21060751
VL - 25
SP - 1616
EP - 1625
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - 11
ER -
ID: 230072498