Essential tremor treated with propranolol: lack of correlation between clinical effect and plasma propranolol levels
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Essential tremor treated with propranolol : lack of correlation between clinical effect and plasma propranolol levels. / Sørensen, P S; Paulson, O B; Steiness, E; Jansen, E C.
I: Annals of Neurology, Bind 9, Nr. 1, 01.1981, s. 53-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Essential tremor treated with propranolol
T2 - lack of correlation between clinical effect and plasma propranolol levels
AU - Sørensen, P S
AU - Paulson, O B
AU - Steiness, E
AU - Jansen, E C
PY - 1981/1
Y1 - 1981/1
N2 - Five patients with essential tremor were treated with increasing daily doses of propranolol. Tremor intensity was assessed after each propranolol dose had been given daily for a period of at least seven days. The evaluation was made 12 to 15 hours after the last propranolol ingestion. It included a semiquantitative clinical tremor evaluation and quantitative registration with an accelerometer. Electronic integration of the accelerometer curves gave an arbitrary measure of tremor intensity. Plasma propranolol concentration was determined at each tremor measurement. The reduction in tremor correlated with increasing propranolol doses, whereas plasma propranolol concentrations varied widely among individuals and could not be correlated with tremor reduction. Most of the patients had considerable diminution in tremor at low propranolol doses, often with an unmeasurable plasma propranolol concentration. Determination of plasma concentrations has little value in long-term treatment of essential tremor with propranolol. The dosage can be sufficiently guided by clinical evaluation of effect.
AB - Five patients with essential tremor were treated with increasing daily doses of propranolol. Tremor intensity was assessed after each propranolol dose had been given daily for a period of at least seven days. The evaluation was made 12 to 15 hours after the last propranolol ingestion. It included a semiquantitative clinical tremor evaluation and quantitative registration with an accelerometer. Electronic integration of the accelerometer curves gave an arbitrary measure of tremor intensity. Plasma propranolol concentration was determined at each tremor measurement. The reduction in tremor correlated with increasing propranolol doses, whereas plasma propranolol concentrations varied widely among individuals and could not be correlated with tremor reduction. Most of the patients had considerable diminution in tremor at low propranolol doses, often with an unmeasurable plasma propranolol concentration. Determination of plasma concentrations has little value in long-term treatment of essential tremor with propranolol. The dosage can be sufficiently guided by clinical evaluation of effect.
KW - Adult
KW - Aged
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Propranolol/administration & dosage
KW - Tremor/drug therapy
U2 - 10.1002/ana.410090110
DO - 10.1002/ana.410090110
M3 - Journal article
C2 - 7212666
VL - 9
SP - 53
EP - 57
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 1
ER -
ID: 279693504