Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery

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Standard

Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery. / Clementson, Sebastian; Matheu, Sergio Armentia; Rørsted, Emil Märcher; Pedersen, Henrik; Jensen, Anders A; Clausen, Rasmus P; Vital, Paulo; Glibstrup, Emil; Jessing, Mikkel; Kristensen, Jesper L.

I: The Journal of Organic Chemistry, Bind 86, Nr. 12, 2021, s. 8248-8262.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Clementson, S, Matheu, SA, Rørsted, EM, Pedersen, H, Jensen, AA, Clausen, RP, Vital, P, Glibstrup, E, Jessing, M & Kristensen, JL 2021, 'Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery', The Journal of Organic Chemistry, bind 86, nr. 12, s. 8248-8262. https://doi.org/10.1021/acs.joc.1c00707

APA

Clementson, S., Matheu, S. A., Rørsted, E. M., Pedersen, H., Jensen, A. A., Clausen, R. P., Vital, P., Glibstrup, E., Jessing, M., & Kristensen, J. L. (2021). Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery. The Journal of Organic Chemistry, 86(12), 8248-8262. https://doi.org/10.1021/acs.joc.1c00707

Vancouver

Clementson S, Matheu SA, Rørsted EM, Pedersen H, Jensen AA, Clausen RP o.a. Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery. The Journal of Organic Chemistry. 2021;86(12):8248-8262. https://doi.org/10.1021/acs.joc.1c00707

Author

Clementson, Sebastian ; Matheu, Sergio Armentia ; Rørsted, Emil Märcher ; Pedersen, Henrik ; Jensen, Anders A ; Clausen, Rasmus P ; Vital, Paulo ; Glibstrup, Emil ; Jessing, Mikkel ; Kristensen, Jesper L. / Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery. I: The Journal of Organic Chemistry. 2021 ; Bind 86, Nr. 12. s. 8248-8262.

Bibtex

@article{e52d035fc9cf4d12956b0a6f31a7378a,
title = "Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery",
abstract = "Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at β2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and (+)-Cocculidine, both found to be potent antagonists of the β2-containing nAChRs.",
author = "Sebastian Clementson and Matheu, {Sergio Armentia} and R{\o}rsted, {Emil M{\"a}rcher} and Henrik Pedersen and Jensen, {Anders A} and Clausen, {Rasmus P} and Paulo Vital and Emil Glibstrup and Mikkel Jessing and Kristensen, {Jesper L}",
year = "2021",
doi = "10.1021/acs.joc.1c00707",
language = "English",
volume = "86",
pages = "8248--8262",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "12",

}

RIS

TY - JOUR

T1 - Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery

AU - Clementson, Sebastian

AU - Matheu, Sergio Armentia

AU - Rørsted, Emil Märcher

AU - Pedersen, Henrik

AU - Jensen, Anders A

AU - Clausen, Rasmus P

AU - Vital, Paulo

AU - Glibstrup, Emil

AU - Jessing, Mikkel

AU - Kristensen, Jesper L

PY - 2021

Y1 - 2021

N2 - Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at β2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and (+)-Cocculidine, both found to be potent antagonists of the β2-containing nAChRs.

AB - Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at β2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and (+)-Cocculidine, both found to be potent antagonists of the β2-containing nAChRs.

U2 - 10.1021/acs.joc.1c00707

DO - 10.1021/acs.joc.1c00707

M3 - Journal article

C2 - 34061521

VL - 86

SP - 8248

EP - 8262

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 12

ER -

ID: 270553746