Epigenetic Deficiencies and Replicative Stress: Driving Cancer Cells to an Early Grave
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Epigenetic Deficiencies and Replicative Stress : Driving Cancer Cells to an Early Grave. / Shoaib, Muhammad; Sørensen, Claus Storgaard.
I: Cancer Cell, Bind 28, Nr. 5, 09.11.2015, s. 545-547.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Epigenetic Deficiencies and Replicative Stress
T2 - Driving Cancer Cells to an Early Grave
AU - Shoaib, Muhammad
AU - Sørensen, Claus Storgaard
N1 - Copyright © 2015 Elsevier Inc. All rights reserved.
PY - 2015/11/9
Y1 - 2015/11/9
N2 - Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.
AB - Cancer cell-specific synthetic lethal interactions entail promising therapeutic possibilities. In this issue of Cancer Cell, Pfister et al. describe a synthetic lethal interaction where cancer cells deficient in H3K36me3 owing to SETD2 loss-of-function mutation are strongly sensitized to inhibition of WEE1, a cell cycle controlling kinase.
KW - Animals
KW - Cell Cycle Proteins
KW - Histones
KW - Humans
KW - Neoplasms
KW - Nuclear Proteins
KW - Nucleotides
KW - Protein-Tyrosine Kinases
KW - Comment
KW - Journal Article
U2 - 10.1016/j.ccell.2015.10.009
DO - 10.1016/j.ccell.2015.10.009
M3 - Journal article
C2 - 26555168
VL - 28
SP - 545
EP - 547
JO - Cancer Cell
JF - Cancer Cell
SN - 1535-6108
IS - 5
ER -
ID: 165717223