TY - JOUR

T1 - Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS)

T2 - A worldwide platform for collaboration

AU - Paschou, Peristera

AU - Jin, Yin

AU - Müller-Vahl, Kirsten

AU - Möller, Harald E.

AU - Rizzo, Renata

AU - Hoekstra, Pieter J.

AU - Roessner, Veit

AU - Debes, Nanette Mol

AU - Worbe, Yulia

AU - Hartmann, Andreas

AU - Mir, Pablo

AU - Cath, Danielle

AU - Neuner, Irene

AU - Eichele, Heike

AU - Zhang, Chencheng

AU - Lewandowska, Katarzyna

AU - Munchau, Alexander

AU - Verrel, Julius

AU - Musil, Richard

AU - Silk, Tim J.

AU - Hanlon, Colleen A.

AU - Bihun, Emily D.

AU - Brandt, Valerie

AU - Dietrich, Andrea

AU - Forde, Natalie

AU - Ganos, Christos

AU - Greene, Deanna J.

AU - Chu, Chunguang

AU - Grothe, Michel J

AU - Hershey, Tamara

AU - Janik, Piotr

AU - Koller, Jonathan M.

AU - Martin-Rodriguez, Juan Francisco

AU - Müller, Karsten

AU - Palmucci, Stefano

AU - Prato, Adriana

AU - Ramkiran, Shukti

AU - Saia, Federica

AU - Szejko, Natalia

AU - Torrecuso, Renzo

AU - Tumer, Zeynep

AU - Uhlmann, Anne

AU - Veselinovic, Tanja

AU - Wolańczyk, Tomasz

AU - Zouki, Jade Jocelyne

AU - Jain, Pritesh

AU - Topaloudi, Apostolia

AU - Kaka, Mary

AU - Yang, Zhiyu

AU - Drineas, Petros

AU - Thomopoulos, Sophia I.

AU - White, Tonya

AU - Veltman, Dick J

AU - Schmaal, Lianne

AU - Stein, Dan J

AU - Buitelaar, Jan

AU - Franke, Barbara

AU - van den Heuvel, Odile

AU - Jahanshad, Neda

AU - Thompson, Paul M.

AU - Black, Kevin J.

N1 - Publisher Copyright: Copyright © 2022 Paschou, Jin, Müller-Vahl, Möller, Rizzo, Hoekstra, Roessner, Mol Debes, Worbe, Hartmann, Mir, Cath, Neuner, Eichele, Zhang, Lewandowska, Munchau, Verrel, Musil, Silk, Hanlon, Bihun, Brandt, Dietrich, Forde, Ganos, Greene, Chu, Grothe, Hershey, Janik, Koller, Martin-Rodriguez, Müller, Palmucci, Prato, Ramkiran, Saia, Szejko, Torrecuso, Tumer, Uhlmann, Veselinovic, Wolańczyk, Zouki, Jain, Topaloudi, Kaka, Yang, Drineas, Thomopoulos, White, Veltman, Schmaal, Stein, Buitelaar, Franke, van den Heuvel, Jahanshad, Thompson and Black.

PY - 2022

Y1 - 2022

N2 - Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.

AB - Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.

KW - brain MRI

KW - ENIGMA

KW - genetics

KW - neuroimaging

KW - Tourette syndrome

U2 - 10.3389/fpsyt.2022.958688

DO - 10.3389/fpsyt.2022.958688

M3 - Journal article

C2 - 36072455

AN - SCOPUS:85138038855

VL - 13

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

SN - 1664-0640

M1 - 958688

ER -