Endoscopic ultrasound for staging of colonic cancer proximal to the rectum: A systematic review and meta-analysis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Endoscopic ultrasound for staging of colonic cancer proximal to the rectum : A systematic review and meta-analysis. / Malmstrøm, Marie Louise; Saftoiu, Adrian; Vilmann, Peter; Klausen, Tobias Wirenfeldt; Gögenur, Ismail.
I: Endoscopic Ultrasound, Bind 5, Nr. 5, 2016, s. 307-314.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Endoscopic ultrasound for staging of colonic cancer proximal to the rectum
T2 - A systematic review and meta-analysis
AU - Malmstrøm, Marie Louise
AU - Saftoiu, Adrian
AU - Vilmann, Peter
AU - Klausen, Tobias Wirenfeldt
AU - Gögenur, Ismail
PY - 2016
Y1 - 2016
N2 - BACKGROUND AND OBJECTIVES: Treatment of colonic cancer patients is highly dependent on the depth of tumor invasion (T-stage) as well as the extension of lymph node involvement (N-stage). We aimed to systematically review the accuracy of endoscopic ultrasound (EUS) for staging of colonic cancer proximal to the rectum.PATIENTS AND METHODS: Men and women with colonic adenocarcinomas were included in the study. EUS staging was compared to histopathology as the gold standard. Outcome measures were T- and N-staging accuracies. Articles were searched in PubMed, Web of Science, The Cochrane Library, and EMBASE.RESULTS: Six studies were identified comparing EUS staging of colonic cancer to histopathology. The pooled-staging sensitivity and specificity were 0.90 and 0.98 for T1 tumors, 0.67 and 0.96 for T2 tumors, and 0.97 and 0.83 for T3/T4 tumors, respectively. Sensitivity and specificity for N + disease were 0.59 and 0.78, respectively.CONCLUSIONS: EUS is a feasible method for T-staging of cancers of the colon proximal to the rectum. The accuracy of lymph node staging needs to be verified by prospective multicenter studies including larger patient populations.
AB - BACKGROUND AND OBJECTIVES: Treatment of colonic cancer patients is highly dependent on the depth of tumor invasion (T-stage) as well as the extension of lymph node involvement (N-stage). We aimed to systematically review the accuracy of endoscopic ultrasound (EUS) for staging of colonic cancer proximal to the rectum.PATIENTS AND METHODS: Men and women with colonic adenocarcinomas were included in the study. EUS staging was compared to histopathology as the gold standard. Outcome measures were T- and N-staging accuracies. Articles were searched in PubMed, Web of Science, The Cochrane Library, and EMBASE.RESULTS: Six studies were identified comparing EUS staging of colonic cancer to histopathology. The pooled-staging sensitivity and specificity were 0.90 and 0.98 for T1 tumors, 0.67 and 0.96 for T2 tumors, and 0.97 and 0.83 for T3/T4 tumors, respectively. Sensitivity and specificity for N + disease were 0.59 and 0.78, respectively.CONCLUSIONS: EUS is a feasible method for T-staging of cancers of the colon proximal to the rectum. The accuracy of lymph node staging needs to be verified by prospective multicenter studies including larger patient populations.
U2 - 10.4103/2303-9027.191610
DO - 10.4103/2303-9027.191610
M3 - Review
C2 - 27803903
VL - 5
SP - 307
EP - 314
JO - Endoscopic Ultrasound
JF - Endoscopic Ultrasound
SN - 2226-7190
IS - 5
ER -
ID: 168932483