ENDO-ERN expert opinion on the differential diagnosis of pubertal delay
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ENDO-ERN expert opinion on the differential diagnosis of pubertal delay. / Persani, Luca; Bonomi, Marco; Cools, Martine; Dattani, Mehul; Dunkel, Leo; Gravholt, Claus H.; Juul, Anders.
I: Endocrine, Bind 71, Nr. 3, 2021, s. 681-688.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - ENDO-ERN expert opinion on the differential diagnosis of pubertal delay
AU - Persani, Luca
AU - Bonomi, Marco
AU - Cools, Martine
AU - Dattani, Mehul
AU - Dunkel, Leo
AU - Gravholt, Claus H.
AU - Juul, Anders
N1 - Publisher Copyright: © 2021, The Author(s).
PY - 2021
Y1 - 2021
N2 - The differential diagnoses of pubertal delay include hypergonadotropic hypogonadism and congenital hypogonadotropic hypogonadism (CHH), as well as constitutional delay of growth and puberty (CDGP). Distinguishing between CDGP and CHH may be challenging, and the scientific community has been struggling to develop diagnostic tests that allow an accurate differential diagnosis. Indeed, an adequate and timely management is critical in order to enable optimal clinical and psychosocial outcomes of the different forms of pubertal delays. In this review, we provide an updated insight on the differential diagnoses of pubertal delay, including the available tests, their meanings and accuracy, as well as some clues to effectively orientate towards either constitutional pubertal delay or pathologic CHH and hypergonadotropic hypogonadism.
AB - The differential diagnoses of pubertal delay include hypergonadotropic hypogonadism and congenital hypogonadotropic hypogonadism (CHH), as well as constitutional delay of growth and puberty (CDGP). Distinguishing between CDGP and CHH may be challenging, and the scientific community has been struggling to develop diagnostic tests that allow an accurate differential diagnosis. Indeed, an adequate and timely management is critical in order to enable optimal clinical and psychosocial outcomes of the different forms of pubertal delays. In this review, we provide an updated insight on the differential diagnoses of pubertal delay, including the available tests, their meanings and accuracy, as well as some clues to effectively orientate towards either constitutional pubertal delay or pathologic CHH and hypergonadotropic hypogonadism.
KW - Constitutional delay of growth and puberty
KW - Gonadal dysgenesis
KW - Hypogonadism
KW - Primary ovarian insufficiency
KW - Pubertal delay
KW - Sex steroid priming
U2 - 10.1007/s12020-021-02626-z
DO - 10.1007/s12020-021-02626-z
M3 - Journal article
C2 - 33512657
AN - SCOPUS:85099909430
VL - 71
SP - 681
EP - 688
JO - Endocrine
JF - Endocrine
SN - 1355-008X
IS - 3
ER -
ID: 285385221