TY - JOUR

T1 - Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo

AU - Ventura, Guilherme

AU - Sedzinski, Jakub

N1 - Publisher Copyright: Copyright © 2022 Ventura and Sedzinski.

PY - 2022

Y1 - 2022

N2 - During embryogenesis, tissues develop into elaborate collectives through a myriad of active mechanisms, with cell migration being one of the most common. As cells migrate, they squeeze through crowded microenvironments to reach the positions where they ultimately execute their function. Much of our knowledge of cell migration has been based on cells’ ability to navigate in vitro and how cells respond to the mechanical properties of the extracellular matrix (ECM). These simplified and largely passive surroundings contrast with the complexity of the tissue environments in vivo, where different cells and ECM make up the milieu cells migrate in. Due to this complexity, comparatively little is known about how the physical interactions between migrating cells and their tissue environment instruct cell movement in vivo. Work in different model organisms has been instrumental in addressing this question. Here, we explore various examples of cell migration in vivo and describe how the physical interplay between migrating cells and the neighboring microenvironment controls cell behavior. Understanding this mechanical cooperation in vivo will provide key insights into organ development, regeneration, and disease.

AB - During embryogenesis, tissues develop into elaborate collectives through a myriad of active mechanisms, with cell migration being one of the most common. As cells migrate, they squeeze through crowded microenvironments to reach the positions where they ultimately execute their function. Much of our knowledge of cell migration has been based on cells’ ability to navigate in vitro and how cells respond to the mechanical properties of the extracellular matrix (ECM). These simplified and largely passive surroundings contrast with the complexity of the tissue environments in vivo, where different cells and ECM make up the milieu cells migrate in. Due to this complexity, comparatively little is known about how the physical interactions between migrating cells and their tissue environment instruct cell movement in vivo. Work in different model organisms has been instrumental in addressing this question. Here, we explore various examples of cell migration in vivo and describe how the physical interplay between migrating cells and the neighboring microenvironment controls cell behavior. Understanding this mechanical cooperation in vivo will provide key insights into organ development, regeneration, and disease.

KW - confinement

KW - durotaxis

KW - in vivo cell migration

KW - mechanotransduction

KW - microenvironment sensing

KW - topography

U2 - 10.3389/fcell.2022.961460

DO - 10.3389/fcell.2022.961460

M3 - Review

C2 - 36238689

AN - SCOPUS:85139563389

VL - 10

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

SN - 2296-634X

M1 - 961460

ER -