Elevated plasma levels of calcitonin gene-related peptide in individuals with rosacea: A cross-sectional case–control study
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Elevated plasma levels of calcitonin gene-related peptide in individuals with rosacea : A cross-sectional case–control study. / Wienholtz, Nita K.F.; Christensen, Casper E.; Ashina, Håkan; Jørgensen, Niklas R; Egeberg, Alexander; Thyssen, Jacob P.; Ashina, Messoud.
I: Journal of the European Academy of Dermatology and Venereology, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Elevated plasma levels of calcitonin gene-related peptide in individuals with rosacea
T2 - A cross-sectional case–control study
AU - Wienholtz, Nita K.F.
AU - Christensen, Casper E.
AU - Ashina, Håkan
AU - Jørgensen, Niklas R
AU - Egeberg, Alexander
AU - Thyssen, Jacob P.
AU - Ashina, Messoud
N1 - Publisher Copyright: © 2024 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.
PY - 2024
Y1 - 2024
N2 - Background: Understanding the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of rosacea might provide new therapeutic avenues for individuals with this disease. Objective: To compare plasma levels of CGRP between individuals with rosacea and healthy controls. Methods: In this cross-sectional case–control study conducted in Copenhagen, Denmark, we collected blood samples from the antecubital vein from adults with rosacea and from healthy controls. Results: We enrolled 123 individuals with rosacea and 68 healthy controls. After adjusting for age and sex, plasma levels of CGRP were significantly higher in individuals with rosacea (mean, 95% confidence interval: 140.21 pmol/L, 128.50–151.92 pmol/L), compared with controls (110.77 pmol/L, 99.91–120.14 pmol/L, p = 0.002). Plasma levels of CGRP were not affected by age, sex, BMI, concomitant migraine, rosacea sub- or phenotype, concomitant disease or current treatment. Limitations: Participants were not age-, sex- and BMI-matched. Conclusions and Relevance: Elevated plasma levels of CGRP in individuals with rosacea suggest a role of CGRP in the pathogenesis of rosacea. Targeting CGRP signalling might hold therapeutic promise in people affected by this disease. Clinicaltrials.gov listing: NCT03872050.
AB - Background: Understanding the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of rosacea might provide new therapeutic avenues for individuals with this disease. Objective: To compare plasma levels of CGRP between individuals with rosacea and healthy controls. Methods: In this cross-sectional case–control study conducted in Copenhagen, Denmark, we collected blood samples from the antecubital vein from adults with rosacea and from healthy controls. Results: We enrolled 123 individuals with rosacea and 68 healthy controls. After adjusting for age and sex, plasma levels of CGRP were significantly higher in individuals with rosacea (mean, 95% confidence interval: 140.21 pmol/L, 128.50–151.92 pmol/L), compared with controls (110.77 pmol/L, 99.91–120.14 pmol/L, p = 0.002). Plasma levels of CGRP were not affected by age, sex, BMI, concomitant migraine, rosacea sub- or phenotype, concomitant disease or current treatment. Limitations: Participants were not age-, sex- and BMI-matched. Conclusions and Relevance: Elevated plasma levels of CGRP in individuals with rosacea suggest a role of CGRP in the pathogenesis of rosacea. Targeting CGRP signalling might hold therapeutic promise in people affected by this disease. Clinicaltrials.gov listing: NCT03872050.
U2 - 10.1111/jdv.19954
DO - 10.1111/jdv.19954
M3 - Journal article
C2 - 38558478
AN - SCOPUS:85189648393
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
SN - 0926-9959
ER -
ID: 393840399