TY - JOUR

T1 - Effekte einer zusätzlichen entzündungshemmenden Therapie mit Carprofen (Rimadyl Rind®) bei schweren Mastitiden hochleistender Milchkühe

AU - Krömker, Volker

AU - Paduch, Jan Hendrik

AU - Abograra, Ismail

AU - Zinke, Claudia

AU - Friedrich, Julia

PY - 2011/3/1

Y1 - 2011/3/1

N2 - This field study focuses on the possible effects of a combination of nonsteroidal antiinflammatory treatment (carprofen) and a local and parenteral antibiotic on cure rates, survival rate and return to milk production of severe clinical mastitis cases. 19 cows in 3 herds (blocked by parity) with severe clinical mastitis during the first 120 d of lactation (median = 28 d) were treated with antibiotics and onehalf of these cows were treated with 1.4 mg/kg bodyweight carprofen (Rimadyl Rind®, Pfizer GmbH Tiergesundheit, Germany). Double milk samples for bacteriology were collected from clinically affected udder quarters before treatment and at 14 (± 3) and 21 (± 3) days after commencement of treatment for cytomicrobiological analysis. Additionally, every single animal was clinically examined on d 1 to 1. Treatments were initiated before culture results. There were no differences between the treatment groups in calving date, days in milk, age, breed, rectal temperature, clinical, bacteriological, cytobacteriological cure rate and in the number of cows that were defined as treatment failures (i. e. died, re-treated, relapse). Six (22.2%) vs. seven (19.4%) cows in the carprofen and control groups failed, respectively. The milk yield was significantly higher in the carprofen-treated group compared with the control group after treatment. The present work gives first indications that treatment of cows with severe clinical mastitis with a combination of carprofen and antibiotics could result in a faster return to milk production compared to treatment with antibiotics alone. If this effect can be affiliated to the administration of carprofen alone has to be examined in further studies.

AB - This field study focuses on the possible effects of a combination of nonsteroidal antiinflammatory treatment (carprofen) and a local and parenteral antibiotic on cure rates, survival rate and return to milk production of severe clinical mastitis cases. 19 cows in 3 herds (blocked by parity) with severe clinical mastitis during the first 120 d of lactation (median = 28 d) were treated with antibiotics and onehalf of these cows were treated with 1.4 mg/kg bodyweight carprofen (Rimadyl Rind®, Pfizer GmbH Tiergesundheit, Germany). Double milk samples for bacteriology were collected from clinically affected udder quarters before treatment and at 14 (± 3) and 21 (± 3) days after commencement of treatment for cytomicrobiological analysis. Additionally, every single animal was clinically examined on d 1 to 1. Treatments were initiated before culture results. There were no differences between the treatment groups in calving date, days in milk, age, breed, rectal temperature, clinical, bacteriological, cytobacteriological cure rate and in the number of cows that were defined as treatment failures (i. e. died, re-treated, relapse). Six (22.2%) vs. seven (19.4%) cows in the carprofen and control groups failed, respectively. The milk yield was significantly higher in the carprofen-treated group compared with the control group after treatment. The present work gives first indications that treatment of cows with severe clinical mastitis with a combination of carprofen and antibiotics could result in a faster return to milk production compared to treatment with antibiotics alone. If this effect can be affiliated to the administration of carprofen alone has to be examined in further studies.

KW - Field study

KW - Nonsteroidal antiinflammatory drug

KW - Severe clinical mastitis

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=79957976184&partnerID=8YFLogxK

U2 - 10.2371/0005-9311-124-161

DO - 10.2371/0005-9311-124-161

M3 - Tidsskriftartikel

C2 - 21465772

AN - SCOPUS:79957976184

VL - 124

SP - 161

EP - 167

JO - Berliner und Muenchener Tieraerztliche Wochenschrift

JF - Berliner und Muenchener Tieraerztliche Wochenschrift

SN - 0005-9366

IS - 3-4

ER -